Results 111 to 120 of about 226,714 (349)

Accelerated and efficient neuronal differentiation of Sox1GFP mouse embryonic stem cells in vitro using nicotinamide [PDF]

, 2014
A major challenge for advancement of clinical neuronal replacement therapies is the production of high yields of purified neuronal populations of appropriate phenotype with control over proliferation to prevent tumorigenesis.
Fricker, Rosemary, Griffin, Sile, Pickard, Mark R.   +2 more
core  

An Ultrapotent, Ultraeconomical, Antifreeze Polypeptide

Advanced Materials, EarlyView.
Simple and inexpensive polypeptides composed of random copolymers of alanine and glutamic acid are effective antifreezes for applications in foods and biomedicine. The polypeptides, inspired by natural extremophile proteins, inhibit the growth of large ice crystals and prevent damage to sensitive biologics.
Thomas J. McPartlon, Charles T. Osborne, Ke Wang, Rachel E. Detwiler, Konrad Meister, Jessica R. Kramer   +5 more
wiley   +1 more source

Implantable Light‐Powered Human Designer Cells for Electrical Energy Generation

Advanced Materials, EarlyView.
Inspired by the eel's electric organ, a miniature implantable biohybrid device is developed to generate electricity under light activation. The device utilizes a light‐dependent ion gradient formation that induced by genetically engineered human designer cells that express light‐sensitive membrane ion channels and proton pumps, working in synergy with ...
Shuai Xue, Zhihua Lin, Debasis Maity, Preetam Guha Ray, Mingqi Xie, Martin Fussenegger   +5 more
wiley   +1 more source

Terapi Topikal Tretinoin 0,025% + Zinc Oral Dibandingkan Topikal Nicotinamide 4% + Zinc Oral Pada Akne Vulgaris [PDF]

, 2017
Latar Belakang : Akne vulgaris merupakan penyakit kulit yang umum terjadi pada remaja dan dewasa. Terapi topikal untuk akne dapat digunakan sebagai monoterapi maupun kombinasi dengan terapi sistemik.
Usodo, G. P. (Gloria), Wibowo, D. A. (Dhega)   +1 more
core  

Engineering Aging: Approaches to Model and Deconstruct Biological Complexity

Advanced Materials, EarlyView.
The macro‐experiences of aging are the result of an accumulation of micro‐changes that occur over time. Abstract The disparity between the global increase in life expectancy and the steady decline in health outcomes with age has been a major driver for developing new ways to research aging.
Habib Joukhdar, Sunny Shinchen Lee, Thomas R. Cox, Yu Suk Choi, Steven G. Wise, Jennifer L. Young, Giselle C. Yeo, Khoon S. Lim   +7 more
wiley   +1 more source

Is sensitization with nicotinamide and carbogen dependent on nicotinamide concentration at the time of irradiation?

International Journal of Radiation Biology, 2004
To determine whether tumour radiosensitization and the therapeutic benefit of administering carbogen with nicotinamide depend upon irradiating at the time of peak drug concentration.Local tumour control of CaNT tumours in CBA mice and acute skin reactions in albino WHT mice were assessed after treatment with 10 X-ray fractions in air, carbogen alone or
Rojas, A, Stratford, MR, Bentzen, S, Denekamp, J   +3 more
openaire   +4 more sources

Reticular Frameworks for Advanced Polymer Materials

Advanced Materials, EarlyView.
Reticular frameworks (RFs) such as metal–organic frameworks, covalent organic frameworks, and hydrogen‐bonded organic frameworks offer versatile platforms for polymer materials innovation, enabling regulated polymerization, efficient macromolecular purification, and polymer functionalization.
Bohan Cheng, Nobuhiko Hosono, Takashi Uemura   +2 more
wiley   +1 more source

Characterization of Sirt2 using conditional RNAi in mice [PDF]

, 2011
Within the past eight years, RNA interference (RNAi) has emerged as a powerful experimental tool for gene function analysis in mice. Reversible control of shRNA mediated RNAi has been achieved by using a tetracycline (tet)-inducible promoter.
Reiss, Martina
core  

Exploring Functionally Enhanced BLP‐Trained Macrophage Subpopulations in S. Aureus Infection: Underlying Mechanisms and Therapeutic Significance

Advanced Science, EarlyView.
BLP‐trained macrophages show augmented resistance to infection, but their mechanisms remain unclear. scRNA‐seq identified 13 BMDM subsets, with two novel anti‐inflammatory/antibacterial subpopulations (C5/C7) emerging post‐BLP training. BLP training activates NRF2, attenuates oxidative stress/ferroptosis, and boosts glycolysis/OXPHOS. Adoptive transfer
Yantong Wan, Yinghao Hong, Xiangjun Ji, Jing Xiang, Jinxi Liu, Lixin Liang, Meng Ren, Wenhan Chen, Tengfei Xu, Zhijie Li, Tieliu Shi, Yong Jiang, Huaping Liang, Jinghua Liu   +13 more
wiley   +1 more source

Nicotinamide in Murine Tuberculosis

Experimental Biology and Medicine, 1955
SummaryExperiments were performed to assess the therapeutic effect of varying the dose and the time of initiation of treatment with nicotinamide in tuberculous mice. No activity was demonstrated for any substance tested that is related to this agent. It was found that treatment instituted prior to infection exerted a striking effect.
openaire   +3 more sources