Results 131 to 140 of about 159,186 (304)

Electronic structure and substituent effects in C6-Substituted nicotinamide derivatives: a DFT study

Open Chemistry
Density functional theory (DFT) calculations were performed to investigate the electronic effects of C6 substitution on the nicotinamide (NA) scaffold. Geometry optimizations, frontier molecular orbital analysis, conceptual DFT descriptors, and molecular
Albalawi Mona O.
doaj   +1 more source

Nicotinamide Inhibition of SIRT5 Variants and SIRT1.

, 2016
Nicotinamide exhibits competitive inhibition against NAD+ during the wild-type SIRT5 and its Y102A mutant catalyzed desuccinylation reactions (A and B); mixed type of inhibition against NAD+ during the Y102A/R105I SIRT5 mutant and SIRT1 catalyzed ...
Manas Haldar (1345884), Sanku Mallik (1325715), Junru Yu (2587810), D. K. Srivastava (1341576)   +3 more
core   +1 more source

Acinar‐Derived Organoids Reveal Stage‐Specific Control of Acinar Plasticity

Advanced Science, EarlyView.
An acinar‐derived organoid system maintains adult pancreatic acinar identity ex vivo, converts it along an ordered acinar‐to‐ductal‐like trajectory, and then partially restores it. Each transition carries its own signal requirement, with EGF/EGFR initiating conversion and a staged glucocorticoid–IGF1R switch driving redifferentiation.
Yongfei Hou, Siyu Li, Chunying Li, Zhifan Lin, Dan He, Li Yang, Liping Fu, Qianyue Zhang, Tianping Zhou, Yao Yao, Xiaolei Yin   +10 more
wiley   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Tracing proliferating potential of lung tumours by [11C]Nicotinamide [PDF]

Many tumours rely on aerobic glycolysis, known as the Warburg effect, to satisfy energy needs and sustain rapid proliferation [1]. High demands of glucose in tumours can be measured by [18F[fluorodeoxyglucose, [18F]FDG, positron emission tomography (PET).
Lewis, David, Solovyev, Dmitry, Brown, Gavin, Bielik, Robert   +3 more
core   +1 more source

Harnessing Methylselenol (CH3SeH): A Highly Effective Platform for Stimuli‐Responsive Delivery With Therapeutic Potential

Advanced Science, EarlyView.
Tools for controlled selenol delivery are crucial for exploring Se‐related biology and medicine, but compound platforms for triggerable release of CH3SeH remain lacking. Herein, we report the first general triggered platform (TD‐MSe) for efficient cyclization release of CH3SeH in live cells.
Wenfang Liang, Liyue Wang, Xuan Wang, Xinran Li, Hao Xing, Lu Sun, Zhen Xi, Long Yi   +7 more
wiley   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Synthesis and structure of diaquabis(nicotinamide-κO)bis(nitrato-κ2O,O′)calcium(II)

Acta Crystallographica Section E: Crystallographic Communications
The title complex, [Ca(NO3)2(C6H6N2O)2(H2O)2], crystallizes with an eight-coordinate Ca2+ ion in a distorted trigonal–dodecahedral coordination environment.
Zulfiya Djumanazarova, Shakhnoza Kadirova, Nuritdin Kattaev, Bakhtiyar Ibragimov, Saule Meldebekova, Jamshid Ashurov   +5 more
doaj   +1 more source

Substituted Nicotinamide Analogues of Nicotinamide Adenine Dinucleotide

Journal of Biological Chemistry, 1963
P, WALTER, N O, KAPLAN
openaire   +2 more sources

Is sensitization with nicotinamide and carbogen dependent on nicotinamide concentration at the time of irradiation?

, 2004
PURPOSE: To determine whether tumour radiosensitization and the therapeutic benefit of administering carbogen with nicotinamide depend upon irradiating at the time of peak drug concentration. MATERIALS AND METHODS: Local tumour control of CaNT tumours in
Stratford, M R L, Rojas, Ana Maria,, Denekamp, Julie, Bentzen, S M   +3 more
core   +1 more source