Results 11 to 20 of about 138,905 (254)

Inhibition of Rat Liver Nicotinamide Adenine Dinucleotide Kinase by Reduced Nicotinamide Adenine Dinucleotide Phosphate

Journal of Biological Chemistry, 1968
Abstract Rat liver NAD kinase (ATP:NAD 2'-phosphotransferase, EC 2.7.1.23) was purified about 70-fold. The Michaelis-Menten constants (Km) for NAD and ATP were 8 x 10-4 m and 2 x 10-3 m, respectively. NAD kinase activity was markedly inhibited by NADH and also NADPH.
James B. Field, Hiroshi Oka
openaire   +4 more sources

Novel GSK-3β Inhibitor Neopetroside A Protects Against Murine Myocardial Ischemia/Reperfusion Injury

JACC: Basic to Translational Science, 2022
Summary: Recent trends suggest novel natural compounds as promising treatments for cardiovascular disease. The authors examined how neopetroside A, a natural pyridine nucleoside containing an α-glycoside bond, regulates mitochondrial metabolism and heart
Hyoung Kyu Kim, PhD, Min Kim, PhD, Jubert C. Marquez, PhD, Seung Hun Jeong, PhD, Tae Hee Ko, PhD, Yeon Hee Noh, MS, Pham Trong Kha, PhD, Ha Min Choi, BS, Dong Hyun Kim, PhD, Jong Tae Kim, PhD, Young Il Yang, PhD, Kyung Soo Ko, PhD, Byoung Doo Rhee, PhD, Larisa K. Shubina, PhD, Tatyana N. Makarieva, PhD, Dmitry Y. Yashunsky, PhD, Alexey G. Gerbst, PhD, Nikolay E. Nifantiev, PhD, Valentin A. Stonik, PhD, Jin Han, PhD   +19 more
doaj   +1 more source

A Fluorescent Analog of Nicotinamide Adenine Dinucleotide [PDF]

Proceedings of the National Academy of Sciences, 1972
Nicotinamide 1, N 6 -ethenoadenine dinucleotide, a fluorescent analog of the coenzyme nicotinamide adenine dinucleotide, has been synthesized by the reaction of chloroacetaldehyde with the coenzyme. The technical fluorescence emission maximum of the analog is 410 nm, upon excitation at 300 nm.
Nelson J. Leonard, Jorge R. Barrio, John A. Secrist   +2 more
openaire   +3 more sources

Circulating blood eNAMPT drives the circadian rhythms in locomotor activity and energy expenditure

Nature Communications, 2023
Nicotinamide phosphoribosyl transferase (NAMPT) is a critical regulator of cellular nicotinamide adenine dinucleotide (NAD)+ levels. Here, the authors show that blood NAMPT contributes to the circadian rhythm generation of locomotor activity and energy ...
Jae Woo Park, Eun Roh, Gil Myoung Kang, So Young Gil, Hyun Kyong Kim, Chan Hee Lee, Won Hee Jang, Se Eun Park, Sang Yun Moon, Seong Jun Kim, So Yeon Jeong, Chae Beom Park, Hyo Sun Lim, Yu Rim Oh, Han Na Jung, Obin Kwon, Byung Soo Youn, Gi Hoon Son, Se Hee Min, Min-Seon Kim   +19 more
doaj   +1 more source

The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity [PDF]

Diabetes & Metabolism Journal, 2014
The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and ...
In-Kyu Lee
doaj   +1 more source

Enzymology of Ca²⁺-Mobilizing Second Messengers Derived from NAD: From NAD Glycohydrolases to (Dual) NADPH Oxidases

Cells, 2023
Nicotinamide adenine dinucleotide (NAD) and its 2′-phosphorylated cousin NADP are precursors for the enzymatic formation of the Ca2+-mobilizing second messengers adenosine diphosphoribose (ADPR), 2′-deoxy-ADPR, cyclic ADPR, and nicotinic acid adenine ...
Andreas H. Guse
doaj   +1 more source

Improved catalytic activity of ruthenium–arene complexes in the reduction of NAD+ [PDF]

, 2012
A series of neutral Ru-II half-sandwich complexes of the type [(eta(6)-arene)Ru(N,N')Cl] where the arene is para-cymene (p-cym), hexamethylbenzene (hmb), biphenyl (bip), or benzene (bn) and N,N' is N-(2-aminoethyl) -4-(trifluoromethyl)benzenesulfonamide (
Abraha Habtemariam, Canivet J., Carrión M. C., Chen Q., Clayden J., Creutz C., Dibenedetto A., Fish R. H., Grau M. M., Grimme S., Guy J. Clarkson, Habtemariam A., Haquette P., Held M., Hileman E. O., Joan J. Soldevila-Barreda, Khan J. A., Kim Y. H., Leiva C., Li X., Lo H. C., Maenaka Y., Martins J. E. D., Matharu D. S., Matthew C. K., Morris R. E., Neese F., Noyori R., Peacock A. F. A., Peter J. Sadler, Pieter C. A. Bruijnincx, Robert J. Deeth, Robertson A., Romain C., Ruppert R., Sandoval C. A., Schäfer A., Sheldrick G. M., Sinnecker S., Tan J., Thai T., Wang C., Wang F., Watanabe M., Weckbecker A., Weigend F., Wolfson A., Wu J., Wu X., Yan Y. K., Ying W., Zhou Z., Zhou Z.   +52 more
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The role of nicotinamide-β-adenine dinucleotide phosphate-H-cytochrome P450 oxidoreductase in the activation of cytochromes [PDF]

BIO Web of Conferences
The aim of this theoretical study is to investigate the mechanisms of action of these enzymes in the context of metabolism in highly productive animals.
Popova Olga, Bylinskaya Daria, Nikitina Anastasia, Ukrainskaya Olga   +3 more
doaj   +1 more source

It takes two to tango: NAD+ and sirtuins in aging/longevity control [PDF]

, 2016
The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a ...
Guarente, Leonard, Imai, Shin-ichiro
core   +2 more sources

Nicotinamide Adenine Dinucleotide Metabolism and Neurodegeneration [PDF]

Antioxidants & Redox Signaling, 2018
Nicotinamide adenine dinucleotide (NAD+) participates in redox reactions and NAD+-dependent signaling processes, which involve the cleavage of NAD+ coupled to posttranslational modifications of proteins or the production of second messengers. Either as a primary cause or as a secondary component of the pathogenic process, mitochondrial dysfunction and ...
Kelby M. Killoy, Marcelo R. Vargas, Mariana Pehar, Benjamin A. Harlan   +3 more
openaire   +3 more sources