Results 11 to 20 of about 142,436 (357)

Improved catalytic activity of ruthenium–arene complexes in the reduction of NAD+ [PDF]

, 2012
A series of neutral Ru-II half-sandwich complexes of the type [(eta(6)-arene)Ru(N,N')Cl] where the arene is para-cymene (p-cym), hexamethylbenzene (hmb), biphenyl (bip), or benzene (bn) and N,N' is N-(2-aminoethyl) -4-(trifluoromethyl)benzenesulfonamide (
Abraha Habtemariam, Canivet J., Carrión M. C., Chen Q., Clayden J., Creutz C., Dibenedetto A., Fish R. H., Grau M. M., Grimme S., Guy J. Clarkson, Habtemariam A., Haquette P., Held M., Hileman E. O., Joan J. Soldevila-Barreda, Khan J. A., Kim Y. H., Leiva C., Li X., Lo H. C., Maenaka Y., Martins J. E. D., Matharu D. S., Matthew C. K., Morris R. E., Neese F., Noyori R., Peacock A. F. A., Peter J. Sadler, Pieter C. A. Bruijnincx, Robert J. Deeth, Robertson A., Romain C., Ruppert R., Sandoval C. A., Schäfer A., Sheldrick G. M., Sinnecker S., Tan J., Thai T., Wang C., Wang F., Watanabe M., Weckbecker A., Weigend F., Wolfson A., Wu J., Wu X., Yan Y. K., Ying W., Zhou Z., Zhou Z.   +52 more
core   +5 more sources

The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity [PDF]

Diabetes & Metabolism Journal, 2014
The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and ...
In-Kyu Lee
doaj   +1 more source

Enzymology of Ca²⁺-Mobilizing Second Messengers Derived from NAD: From NAD Glycohydrolases to (Dual) NADPH Oxidases

Cells, 2023
Nicotinamide adenine dinucleotide (NAD) and its 2′-phosphorylated cousin NADP are precursors for the enzymatic formation of the Ca2+-mobilizing second messengers adenosine diphosphoribose (ADPR), 2′-deoxy-ADPR, cyclic ADPR, and nicotinic acid adenine ...
Andreas H. Guse
doaj   +1 more source

It takes two to tango: NAD+ and sirtuins in aging/longevity control [PDF]

, 2016
The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a ...
Guarente, Leonard, Imai, Shin-ichiro
core   +2 more sources

The role of nicotinamide-β-adenine dinucleotide phosphate-H-cytochrome P450 oxidoreductase in the activation of cytochromes [PDF]

BIO Web of Conferences
The aim of this theoretical study is to investigate the mechanisms of action of these enzymes in the context of metabolism in highly productive animals.
Popova Olga, Bylinskaya Daria, Nikitina Anastasia, Ukrainskaya Olga   +3 more
doaj   +1 more source

Design, Synthesis and SAR Studies of NAD Analogues as Potent Inhibitors towards CD38 NADase

Molecules, 2014
Nicotinamide adenine dinucleotide (NAD), one of the most important coenzymes in the cells, is a substrate of the signaling enzyme CD38, by which NAD is converted to a second messenger, cyclic ADP-ribose, which releases calcium from intracellular calcium ...
Shengjun Wang, Wenjie Zhu, Xuan Wang, Jianguo Li, Kehui Zhang, Liangren Zhang, Yong-Juan Zhao, Hon Cheung Lee, Lihe Zhang   +8 more
doaj   +1 more source

Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding [PDF]

, 2016
Funding: The Scottish Government's Rural and Environment Science and Analytical Services Division.Peer ...
Drew, Janice E., Farquharson, Andrew J., Horgan, Graham W, Williams, Lynda M.   +3 more
core   +1 more source

RNA Capping by Transcription Initiation with Non-canonical Initiating Nucleotides (NCINs): Determination of Relative Efficiencies of Transcription Initiation with NCINs and NTPs

Bio-Protocol, 2017
It recently has been established that adenine-containing cofactors, including nicotinamide adenine dinucleotide (NAD+), reduced nicotinamide adenine dinucleotide (NADH), and 3’-desphospho-coenzyme A (dpCoA), can serve as ‘non-canonical initiating ...
Jeremy Bird, Bryce Nickels, Richard Ebright   +2 more
doaj   +1 more source

Bacterial PncA improves diet-induced NAFLD in mice by enabling the transition from nicotinamide to nicotinic acid

Communications Biology, 2023
Bacterial nicotinamidase/pyrazinamidase PncA increases host nicotinamide adenine dinucleotide (NAD+) levels and ameliorates diet-induced non-alcoholic fatty liver disease (NAFLD) in mice.
Shengyu Feng, Liuling Guo, Hao Wang, Shanshan Yang, Hailiang Liu   +4 more
doaj   +1 more source

Nicotinamide adenine dinucleotide as a photocatalyst [PDF]

Science Advances, 2019
Nicotinamide adenine dinucleotide functions as a molecular photocatalyst, distinct from its pivotal roles in biological processes.
Jinhyun Kim, Sahng Ha Lee, Florian Tieves, Caroline E. Paul, Frank Hollmann, Chan Beum Park   +5 more
openaire   +5 more sources