Results 21 to 30 of about 90,416 (304)

Novel GSK-3β Inhibitor Neopetroside A Protects Against Murine Myocardial Ischemia/Reperfusion Injury

JACC: Basic to Translational Science, 2022
Summary: Recent trends suggest novel natural compounds as promising treatments for cardiovascular disease. The authors examined how neopetroside A, a natural pyridine nucleoside containing an α-glycoside bond, regulates mitochondrial metabolism and heart
Hyoung Kyu Kim, PhD, Min Kim, PhD, Jubert C. Marquez, PhD, Seung Hun Jeong, PhD, Tae Hee Ko, PhD, Yeon Hee Noh, MS, Pham Trong Kha, PhD, Ha Min Choi, BS, Dong Hyun Kim, PhD, Jong Tae Kim, PhD, Young Il Yang, PhD, Kyung Soo Ko, PhD, Byoung Doo Rhee, PhD, Larisa K. Shubina, PhD, Tatyana N. Makarieva, PhD, Dmitry Y. Yashunsky, PhD, Alexey G. Gerbst, PhD, Nikolay E. Nifantiev, PhD, Valentin A. Stonik, PhD, Jin Han, PhD   +19 more
doaj   +1 more source

Nicotinamide Adenine Dinucleotide Metabolism and Neurodegeneration [PDF]

Antioxidants & Redox Signaling, 2018
Nicotinamide adenine dinucleotide (NAD+) participates in redox reactions and NAD+-dependent signaling processes, which involve the cleavage of NAD+ coupled to posttranslational modifications of proteins or the production of second messengers. Either as a primary cause or as a secondary component of the pathogenic process, mitochondrial dysfunction and ...
Mariana, Pehar, Benjamin A, Harlan, Kelby M, Killoy, Marcelo R, Vargas   +3 more
openaire   +2 more sources

Circulating blood eNAMPT drives the circadian rhythms in locomotor activity and energy expenditure

Nature Communications, 2023
Nicotinamide phosphoribosyl transferase (NAMPT) is a critical regulator of cellular nicotinamide adenine dinucleotide (NAD)+ levels. Here, the authors show that blood NAMPT contributes to the circadian rhythm generation of locomotor activity and energy ...
Jae Woo Park, Eun Roh, Gil Myoung Kang, So Young Gil, Hyun Kyong Kim, Chan Hee Lee, Won Hee Jang, Se Eun Park, Sang Yun Moon, Seong Jun Kim, So Yeon Jeong, Chae Beom Park, Hyo Sun Lim, Yu Rim Oh, Han Na Jung, Obin Kwon, Byung Soo Youn, Gi Hoon Son, Se Hee Min, Min-Seon Kim   +19 more
doaj   +1 more source

The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity [PDF]

Diabetes & Metabolism Journal, 2014
The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and ...
In-Kyu Lee
doaj   +1 more source

Enzymology of Ca²⁺-Mobilizing Second Messengers Derived from NAD: From NAD Glycohydrolases to (Dual) NADPH Oxidases

Cells, 2023
Nicotinamide adenine dinucleotide (NAD) and its 2′-phosphorylated cousin NADP are precursors for the enzymatic formation of the Ca2+-mobilizing second messengers adenosine diphosphoribose (ADPR), 2′-deoxy-ADPR, cyclic ADPR, and nicotinic acid adenine ...
Andreas H. Guse
doaj   +1 more source

The oxidized form of nicotinamide adenine dinucleotide [PDF]

Acta Crystallographica Section C Crystal Structure Communications, 2000
The crystal structure of the free acid form of NAD+ tetrahydrate (nicotin­amide adenine dinucleotide tetrahydrate or 3-carbamoyl-1-β-d-ribo­furan­osyl­pyridinium hydro­xide 5′-ester with adenosine 5′-pyrophosphate inner salt tetrahydrate, C21H27N7O14P2·4H2O) has been determined at 100 K.
Guillot, Benoit, Jelsch, Christian, Lecomte, Claude   +2 more
openaire   +3 more sources

Design, Synthesis and SAR Studies of NAD Analogues as Potent Inhibitors towards CD38 NADase

Molecules, 2014
Nicotinamide adenine dinucleotide (NAD), one of the most important coenzymes in the cells, is a substrate of the signaling enzyme CD38, by which NAD is converted to a second messenger, cyclic ADP-ribose, which releases calcium from intracellular calcium ...
Shengjun Wang, Wenjie Zhu, Xuan Wang, Jianguo Li, Kehui Zhang, Liangren Zhang, Yong-Juan Zhao, Hon Cheung Lee, Lihe Zhang   +8 more
doaj   +1 more source

Bacterial PncA improves diet-induced NAFLD in mice by enabling the transition from nicotinamide to nicotinic acid

Communications Biology, 2023
Bacterial nicotinamidase/pyrazinamidase PncA increases host nicotinamide adenine dinucleotide (NAD+) levels and ameliorates diet-induced non-alcoholic fatty liver disease (NAFLD) in mice.
Shengyu Feng, Liuling Guo, Hao Wang, Shanshan Yang, Hailiang Liu   +4 more
doaj   +1 more source

RNA Capping by Transcription Initiation with Non-canonical Initiating Nucleotides (NCINs): Determination of Relative Efficiencies of Transcription Initiation with NCINs and NTPs

Bio-Protocol, 2017
It recently has been established that adenine-containing cofactors, including nicotinamide adenine dinucleotide (NAD+), reduced nicotinamide adenine dinucleotide (NADH), and 3’-desphospho-coenzyme A (dpCoA), can serve as ‘non-canonical initiating ...
Jeremy Bird, Bryce Nickels, Richard Ebright   +2 more
doaj   +1 more source

Studies with Analogues of Nicotinamide Adenine Dinucleotide [PDF]

European Journal of Biochemistry, 1974
Through a series of correlative studies, the stereochemistry of the enzymatic processes with the coenzyme analogues of NAD+, 3‐acetylpyridine‐adenine dinucleotide, thionicotinamide‐adenine dinucleotide and 3‐cyanopyridine‐adenine dinucleotide, have been examined for horse liver and yeast alcohol dehydrogenase (both A‐specific for NAD+) and glutamate ...
J F, Biellmann, C G, Hirth, M J, Jung, N, Rosenheimer, A D, Wrixon   +4 more
openaire   +2 more sources