Results 21 to 30 of about 63,423 (202)

Study of mechanism of interaction of truncated isoniazid–nicotinamide adenine dinucleotide adduct against multiple enzymes of Mycobacterium tuberculosis by a computational approach

International Journal of Mycobacteriology, 2015
Objective/Background: Isoniazid (INH) is one of the effective antituberculosis (TB) drugs used for TB treatment. However, most of the drug-resistant Mycobacterium tuberculosis (MTB) clinical strains are resistant to INH, a first-line antituberculous drug.
Lingaraja Jena, Shraddha Deshmukh, Pranita Waghmare, Satish Kumar, Bhaskar C Harinath   +4 more
doaj   +1 more source

Shc Is Implicated in Calreticulin-Mediated Sterile Inflammation in Alcoholic HepatitisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background & Aims: Src homology and collagen (Shc) proteins are major adapters to extracellular signals, however, the regulatory role of Shc isoforms in sterile inflammatory responses in alcoholic hepatitis (AH) has not been fully investigated.
Yuan Li, Joy X. Jiang, Weiguo Fan, Sarah R. Fish, Suvarthi Das, Parul Gupta, Gergely Mozes, Lorand Vancza, Sutapa Sarkar, Koshi Kunimoto, Dongning Chen, Hyesuk Park, Dahn Clemens, Alexey Tomilov, Gino Cortopassi, Natalie J. Török   +15 more
doaj   +1 more source

Malate dehydrogenase isolated from extremely halophilic bacteria of the Dead Sea. 2. Effect of salt on the catalytic activity and structure [PDF]

, 1977
Mevarech M, Neumann E. Malate dehydrogenase isolated from extremely halophilic bacteria of the Dead Sea. 2. Effect of salt on the catalytic activity and structure. Biochemistry.
Mevarech, Moshe, Neumann, Eberhard
core   +1 more source

Nicotinamide adenine dinucleotide treatment confers resistance to neonatal ischemia and hypoxia: effects on neurobehavioral phenotypes

Neural Regeneration Research
Neonatal hypoxic-ischemic brain injury is the main cause of hypoxic-ischemic encephalopathy and cerebral palsy. Currently, there are few effective clinical treatments for neonatal hypoxic-ischemic brain injury.
Xiaowen Xu, Xinxin Wang, Li Zhang, Yiming Jin, Lili Li, Meifang Jin, Lianyong Li, Hong Ni   +7 more
doaj   +1 more source

Nicotinamide adenine dinucleotide (reduced)

, 2017
Inelastic Neutron Scattering spectrum of Nicotinamide adenine dinucleotide (reduced), C₆H₆N₂O, measured on the TFXA ...
R. E. Hester, University of York
core   +1 more source

Early Evolutionary Selection of NAD Biosynthesis Pathway in Bacteria

Metabolites, 2022
Bacteria use two alternative pathways to synthesize nicotinamide adenine dinucleotide (NAD) from nicotinamide (Nam). A short, two-step route proceeds through nicotinamide mononucleotide (NMN) formation, whereas the other pathway, a four-step route ...
Suraj Sharma, Yin-Chen Hsieh, Jörn Dietze, Mathias Bockwoldt, Øyvind Strømland, Mathias Ziegler, Ines Heiland   +6 more
doaj   +1 more source

Nicotinamide adenine dinucleotide (oxidised)

, 2017
Inelastic Neutron Scattering spectrum of Nicotinamide adenine dinucleotide (oxidised), C₆H₆N₂O, measured on the TFXA ...
R. E. Hester, UNiversity of York
core   +1 more source

Nicotinamide adenine dinucleotide is transported into mammalian mitochondria

eLife, 2018
Mitochondrial NAD levels influence fuel selection, circadian rhythms, and cell survival under stress. It has alternately been argued that NAD in mammalian mitochondria arises from import of cytosolic nicotinamide (NAM), nicotinamide mononucleotide (NMN),
Antonio Davila, Ling Liu, Karthikeyani Chellappa, Philip Redpath, Eiko Nakamaru-Ogiso, Lauren M Paolella, Zhigang Zhang, Marie E Migaud, Joshua D Rabinowitz, Joseph A Baur   +9 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source