Results 11 to 20 of about 63,423 (202)

Design, Synthesis and SAR Studies of NAD Analogues as Potent Inhibitors towards CD38 NADase

Molecules, 2014
Nicotinamide adenine dinucleotide (NAD), one of the most important coenzymes in the cells, is a substrate of the signaling enzyme CD38, by which NAD is converted to a second messenger, cyclic ADP-ribose, which releases calcium from intracellular calcium ...
Shengjun Wang, Wenjie Zhu, Xuan Wang, Jianguo Li, Kehui Zhang, Liangren Zhang, Yong-Juan Zhao, Hon Cheung Lee, Lihe Zhang   +8 more
doaj   +1 more source

Bacterial PncA improves diet-induced NAFLD in mice by enabling the transition from nicotinamide to nicotinic acid

Communications Biology, 2023
Bacterial nicotinamidase/pyrazinamidase PncA increases host nicotinamide adenine dinucleotide (NAD+) levels and ameliorates diet-induced non-alcoholic fatty liver disease (NAFLD) in mice.
Shengyu Feng, Liuling Guo, Hao Wang, Shanshan Yang, Hailiang Liu   +4 more
doaj   +1 more source

RNA Capping by Transcription Initiation with Non-canonical Initiating Nucleotides (NCINs): Determination of Relative Efficiencies of Transcription Initiation with NCINs and NTPs

Bio-Protocol, 2017
It recently has been established that adenine-containing cofactors, including nicotinamide adenine dinucleotide (NAD+), reduced nicotinamide adenine dinucleotide (NADH), and 3’-desphospho-coenzyme A (dpCoA), can serve as ‘non-canonical initiating ...
Jeremy Bird, Bryce Nickels, Richard Ebright   +2 more
doaj   +1 more source

Cofactor regeneration by a soluble pyridine nucleotide transhydrogenase for biological production of hydromorphone [PDF]

, 2000
We have applied the soluble pyridine nucleotide transhydrogenase of Pseudomonas fluorescens to a cell-free system for the regeneration of the nicotinamide cofactors NAD and NADP in the biological production of the important semisynthetic opiate drug ...
French, C E, Walker, E H, Bruce, N C, Rathbone, D A, Boonstra, B   +4 more
core   +1 more source

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures

Cell Reports, 2019
Summary: Nicotinamide adenine dinucleotide (NAD+) is modulated by conditions of metabolic stress and has been reported to decline with aging in preclinical models, but human data are sparse.
Yasir S. Elhassan, Katarina Kluckova, Rachel S. Fletcher, Mark S. Schmidt, Antje Garten, Craig L. Doig, David M. Cartwright, Lucy Oakey, Claire V. Burley, Ned Jenkinson, Martin Wilson, Samuel J.E. Lucas, Ildem Akerman, Alex Seabright, Yu-Chiang Lai, Daniel A. Tennant, Peter Nightingale, Gareth A. Wallis, Konstantinos N. Manolopoulos, Charles Brenner, Andrew Philp, Gareth G. Lavery   +21 more
doaj   +1 more source

Metabolic Profiling of Human Gastric Cancer Cells Treated With Salazosulfapyridine

Technology in Cancer Research & Treatment, 2020
Purpose: The adhesion molecule cluster of differentiation 44v9 interacts with and stabilizes the cystine/glutamate exchanger protein, which functions as a transporter of cystine.
Kohei Takizawa MD, Koji Muramatsu PA, Kouji Maruyama PhD, Kenichi Urakami MD, PhD, Takashi Sugino MD, PhD, Masatoshi Kusuhara MD, PhD, Ken Yamaguchi MD, PhD, Hiroyuki Ono MD, PhD, Yuko Kitagawa MD, PhD   +8 more
doaj   +1 more source

Association of advanced glycation end products in Dupuytren disease

Journal of Orthopaedic Surgery and Research, 2018
Background Advanced glycation end products are associated with aging, hyperglycemia, and oxidative stress. Accumulation of advanced glycation end products can cause various pathological conditions; however, the association of Dupuytren’s disease with ...
Fumiaki Takase, Yutaka Mifune, Atsuyuki Inui, Yasuhiro Ueda, Takeshi Kataoka, Takeshi Kokubu, Ryosuke Kuroda   +6 more
doaj   +1 more source

Adenine Nucleotide and Nicotinamide Adenine Dinucleotide Measurements in Plants

, 2020
As the principal co-factors of many metabolic pathways, the measurement of both adenine nucleotides and nicotinamide adenine dinucleotide provides important information about cellular energy metabolism.
Yves Gibon, Alisdair R. Fernie, FERNIE, Alisdair, ZHANG, Youjun, BOLZE, Antje, GIBON, Yves, Youjun Zhang, Antje Bolze, Ina Krahnert, KRAHNERT, Ina   +9 more
core   +2 more sources

Clinical Evidence for Targeting NAD Therapeutically

Pharmaceuticals, 2020
Nicotinamide adenine dinucleotide (NAD) pharmacology is a promising class of treatments for age-related conditions that are likely to have a favorable side effect profile for human use, given the widespread use of the NAD precursor vitamin B3 supplements.
Dina Radenkovic, Reason, Eric Verdin
doaj   +1 more source

TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity

mAbs, 2022
Cluster of differentiation 38 (CD38) is an ecto-enzyme expressed primarily on immune cells that metabolizes nicotinamide adenine dinucleotide (NAD+) to adenosine diphosphate ribose or cyclic ADP-ribose and nicotinamide.
Harshad S. Ugamraj, Kevin Dang, Laure-Hélène Ouisse, Benjamin Buelow, Eduardo N. Chini, Giulia Castello, James Allison, Starlynn C Clarke, Laura M. Davison, Roland Buelow, Rong Deng, Suhasini Iyer, Ute Schellenberger, Sankar N. Manika, Shipra Bijpuria, Astrid Musnier, Anne Poupon, Maria Cristina Cuturi, Wim van Schooten, Pranjali Dalvi   +19 more
doaj   +1 more source