Results 51 to 60 of about 138,905 (254)

Therapeutic potential of nicotinamide adenine dinucleotide (NAD)

European Journal of Pharmacology, 2020
Nicotinamide adenine nucleotide (NAD) is a small ubiquitous hydrophilic cofactor that participates in several aspects of cellular metabolism. As a coenzyme it has an essential role in the regulation of energetic metabolism, but it is also a cosubstrate for enzymes that regulate fundamental biological processes such as transcriptional regulation ...
Josep M. Suñé-Negre, Encarna García-Montoya, Marta Arenas-Jal, Marta Arenas-Jal   +3 more
openaire   +4 more sources

New insights into the autophagy-NAD axis in brain disease

Cell Reports, 2023
Sun et al. demonstrate that defects in autophagy cause nicotinamide adenine dinucleotide (NAD) depletion and neurotoxicity.1 Restoring NAD levels rescues cytotoxicity in autophagy-deficient neurons, providing a potential therapy for neurodegenerative and
Maria Jose Perez, Michela Deleidi
doaj   +1 more source

Controlled biotechnological production of polyhydroxyalkanoates [PDF]

, 2012
Předložená diplomová práce se zabývá produkcí polyhydroxyalkanoátů (PHA) bakterií Cupriavidus necator H16. Cílem práce byla příprava, selekce a charakterizace mutantních kmenů schopných vyšší produkce PHA.
Šnajdar, Ondřej
core  

Metabolic and Organelle Morphology Defects in Mice and Human Patients Define Spinocerebellar Ataxia Type 7 as a Mitochondrial Disease

Cell Reports, 2019
Summary: Spinocerebellar ataxia type 7 (SCA7) is a retinal-cerebellar degenerative disorder caused by CAG-polyglutamine (polyQ) repeat expansions in the ataxin-7 gene.
Jacqueline M. Ward, Colleen A. Stoyas, Pawel M. Switonski, Farid Ichou, Weiwei Fan, Brett Collins, Christopher E. Wall, Isaac Adanyeguh, Chenchen Niu, Bryce L. Sopher, Chizuru Kinoshita, Richard S. Morrison, Alexandra Durr, Alysson R. Muotri, Ronald M. Evans, Fanny Mochel, Albert R. La Spada   +16 more
doaj   +1 more source

Mechanism of the inhibition of elevated CO₂ atmosphere on enzymatic browning of fresh-cut lotus roots

浙江大学学报. 农业与生命科学版, 2020
Enzymatic browning is one of the main factors affecting the quality and shelf life of fresh-cut lotus root. The present study aimed to investigate the mechanism of inhibition of elevated carbon dioxide (CO2) on enzymatic browning by applying 20% CO2 to ...
LI Dong, ZHAN Zhihao, ZHOU Xinyue, LI Yintao, LI Li, LIN Xingyu, XU Yanqun, LUO Zisheng   +7 more
doaj   +1 more source

General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH [PDF]

, 2013
To date, efforts to switch the cofactor specificity of oxidoreductases from nicotinamide adenine dinucleotide phosphate (NADPH) to nicotinamide adenine dinucleotide (NADH) have been made on a case-by- case basis with varying degrees of success.
Arnold, Frances H., Brinkmann-Chen, Sabine, Brustad, Eric M., Cahn, Jackson K. B., Flock, Tilman, McIntosh, John A., Meinhold, Peter, Snow, Christopher D., Zhang, Liang   +8 more
core   +1 more source

Biosynthesis of Nicotinamide Adenine Dinucleotide in Mitochondria [PDF]

European Journal of Biochemistry, 1975
Isolated rat liver mitochondria incorporate [14C]nicotinamide into NAD. Nicotinic acid and quinolinic acid are not utilized. The incorporation of nicotinamide into NAD is stimulated by ATP. After incubation of the mitochondria with [14C]nicotinamide, labeled NMN can be isolated.
Hans Grunicke, Heinz J. Keller, Bernd Puschendorf, Abdelmoghit Benaguid   +3 more
openaire   +2 more sources

The function of nicotinamide phosphoribosyl transferase (NAMPT) and its role in diseases

Frontiers in Molecular Biosciences
Nicotinamide phosphoribosyl transferase (NAMPT) is a rate-limiting enzyme in the mammalian nicotinamide adenine dinucleotide (NAD) salvage pathway, and plays a vital role in the regulation of cell metabolic activity, reprogramming, aging and apoptosis ...
Aihong Peng, Junqin Li, Jianxiao Xing, Yuanjun Yao, Xuping Niu, Kaiming Zhang   +5 more
doaj   +1 more source

Coordinated transcriptional regulation between a reactive oxygen species-responsive gene network and the circadian clock in Arabidopsis thaliana : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Plant Biology at Massey University, Plant Biology, New Zealand [PDF]

, 2012
Most organisms have evolved endogenous biological clocks as internal timekeepers to fine-tune physiological processes to the external environment. Energetic cycles such as photosynthesis and glycolytic cycles are physiological processes that have ...
Lai, Alvina Grace
core  

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion [PDF]

, 2016
Overexpression of the NAD(+) biosynthetic enzyme NMNAT1 leads to preservation of injured axons. While increased NAD(+) or decreased NMN levels are thought to be critical to this process, the mechanism(s) of this axon protection remain obscure.
Araki, Babetto, Coleman, Conforti, Di Stefano, Elliott, Gerdts, Gerdts, Gerdts, Gerdts, Gilley, Gilley, Hara, Hikosaka, Lois, Mack, Osterloh, Revollo, Sasaki, Sasaki, Sasaki, Sasaki, Szretter, Wang, Wang   +24 more
core   +3 more sources