Results 61 to 70 of about 134,103 (347)

Coordinated transcriptional regulation between a reactive oxygen species-responsive gene network and the circadian clock in Arabidopsis thaliana : a thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Plant Biology at Massey University, Plant Biology, New Zealand [PDF]

, 2012
Most organisms have evolved endogenous biological clocks as internal timekeepers to fine-tune physiological processes to the external environment. Energetic cycles such as photosynthesis and glycolytic cycles are physiological processes that have ...
Lai, Alvina Grace
core  

Biosynthesis of Nicotinamide Adenine Dinucleotide in Mitochondria [PDF]

European Journal of Biochemistry, 1975
Isolated rat liver mitochondria incorporate [14C]nicotinamide into NAD. Nicotinic acid and quinolinic acid are not utilized. The incorporation of nicotinamide into NAD is stimulated by ATP. After incubation of the mitochondria with [14C]nicotinamide, labeled NMN can be isolated.
Hans Grunicke, Heinz J. Keller, Bernd Puschendorf, Abdelmoghit Benaguid   +3 more
openaire   +2 more sources

Novel Drug‐Testing Platform for Vascular Injury‐induced Intimal Hyperplasia Using a Microphysiological System

Advanced Healthcare Materials, EarlyView.
This study develops a 3D vascular injury model using a microphysiological system that mimics key features of intimal hyperplasia. Antiproliferative drugs reduced VSMC proliferation but worsened endothelialdenudation. A combination of diphenyleneiodonium and quercetin effectively reduced proliferation and migration of VSMC and inflammation while ...
Ungsig Nam, HyeMi Kim, Jeong Ah Kim, Ki‐Hwan Nam, Kye‐Sung Lee, Hwan Hur, Jessie S. Jeon, Ji Yong Bae   +7 more
wiley   +1 more source

The function of nicotinamide phosphoribosyl transferase (NAMPT) and its role in diseases

Frontiers in Molecular Biosciences
Nicotinamide phosphoribosyl transferase (NAMPT) is a rate-limiting enzyme in the mammalian nicotinamide adenine dinucleotide (NAD) salvage pathway, and plays a vital role in the regulation of cell metabolic activity, reprogramming, aging and apoptosis ...
Aihong Peng, Junqin Li, Jianxiao Xing, Yuanjun Yao, Xuping Niu, Kaiming Zhang   +5 more
doaj   +1 more source

New insights into the autophagy-NAD axis in brain disease

Cell Reports, 2023
Sun et al. demonstrate that defects in autophagy cause nicotinamide adenine dinucleotide (NAD) depletion and neurotoxicity.1 Restoring NAD levels rescues cytotoxicity in autophagy-deficient neurons, providing a potential therapy for neurodegenerative and
Maria Jose Perez, Michela Deleidi
doaj   +1 more source

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion [PDF]

, 2016
Overexpression of the NAD(+) biosynthetic enzyme NMNAT1 leads to preservation of injured axons. While increased NAD(+) or decreased NMN levels are thought to be critical to this process, the mechanism(s) of this axon protection remain obscure.
Araki, Babetto, Coleman, Conforti, Di Stefano, Elliott, Gerdts, Gerdts, Gerdts, Gerdts, Gilley, Gilley, Hara, Hikosaka, Lois, Mack, Osterloh, Revollo, Sasaki, Sasaki, Sasaki, Sasaki, Szretter, Wang, Wang   +24 more
core   +3 more sources

Poly(hydroxy‐oxazolidone) Thermoplastic Elastomers for Safer, Greener and Customizable Blood‐Contacting Medical Devices

Advanced Healthcare Materials, EarlyView.
A poly(hydroxy‐oxazolidone) (PHOx) is synthesized from CO2‐based precursors, enabling the up‐cycling of this waste material. After synthesis, PHOx shows thermoplastic properties, and can therefore be processed by many temperature‐dependent techniques. PHOx is hemocompatible, anti‐adhesive, and biocompatible, which is demonstrated in vitro and in vivo ...
Sofia F. Melo, Anna Pierrard, Fréderic Lifrange, Marco Caliari, Céline D'Emal, Margaux Debuisson, Haritz Sardon, Philippe Delvenne, Patrizio Lancellotti, Christophe Detrembleur, Christine Jérôme, Cécile Oury   +11 more
wiley   +1 more source

Digitonin‐Loaded Nanoscale Metal–Organic Framework for Mitochondria‐Targeted Radiotherapy‐Radiodynamic Therapy and Disulfidptosis

Advanced Materials, EarlyView.
A mitochondria‐targeted cationic nanoscale metal organic framework shows strong radiotherapy‐radiodynamic therapy effects and selectively releases digitonin in acidic tumor microenvironments to induce disulfidptosis of cancer cells and downregulate immune checkpoints in cancer and T cells, thereby eliciting strong antitumor immunity to effectively ...
Wenyao Zhen, Yingjie Fan, Tomas Germanas, Langston Tillman, Jinhong Li, Abigail L. Blenko, Ralph R. Weichselbaum, Wenbin Lin   +7 more
wiley   +1 more source

Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage

Nature Communications, 2019
Nicotinamide adenine dinucleotide (NAD+) sustains cellular energy metabolism, functions as a substrate of Sirt and PARP enzymes, and its supplementation is explored therapeutically in aging and other contexts.
Audrey Sambeat, Joanna Ratajczak, Magali Joffraud, José L. Sanchez-Garcia, Maria P. Giner, Armand Valsesia, Judith Giroud-Gerbetant, Miriam Valera-Alberni, Angelique Cercillieux, Marie Boutant, Sameer S. Kulkarni, Sofia Moco, Carles Canto   +12 more
doaj   +1 more source

General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH [PDF]

, 2013
To date, efforts to switch the cofactor specificity of oxidoreductases from nicotinamide adenine dinucleotide phosphate (NADPH) to nicotinamide adenine dinucleotide (NADH) have been made on a case-by- case basis with varying degrees of success.
Arnold, Frances H., Brinkmann-Chen, Sabine, Brustad, Eric M., Cahn, Jackson K. B., Flock, Tilman, McIntosh, John A., Meinhold, Peter, Snow, Christopher D., Zhang, Liang   +8 more
core   +1 more source