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Crystal structure of human nicotinamide mononucleotide adenylyltransferase in complex with NMN [PDF]
FEBS Letters, 2002 The final step in the biosynthesis of nicotinamide-adenine dinucleotide, a major coenzyme in cellular redox reactions and involved in intracellular signaling, is catalyzed by the enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT).
Mathias Ziegler +2 more
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Biological synthesis of nicotinamide mononucleotide
Biotechnology Letters, 2021Nicotinamide mononucleotide (NMN) or Nicotinamide-1-ium-1-β-D-ribofuranoside 5'-phosphate is a nucleotide that can be converted into nicotinamide adenine dinucleotide (NAD) in human cells. NMN has recently attracted great attention because of its potential as an anti-aging drug, leading to great efforts for its effective manufacture.
Qi Shen +6 more
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A method for the purification of nicotinamide mononucleotide
Archives of Biochemistry and Biophysics, 1954Abstract Purified nicotinamide mononucleotide (NMN) has been prepared by incubation of diphosphopyridine nucleotide (DPN) with potato pyrophosphatase in a nonphosphate buffer and in the presence of fluoride. The NMN formed is adsorbed on charcoal followed by elution with aqueous isoamyl alcohol. This eluate is passed through Dowex 1 chloride, and NMN
G W, PLAUT, K A, PLAUT
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A Novel Preparation of Nicotinamide Mononucleotide
Nucleosides and Nucleotides, 1994Nicotinamide mononucleotide is conveniently prepared from nicotinamide adenine dinucleotide by specific hydrolysis of the pyrophosphate bond using the Zr4+ ion as catalyst.
R, Liu, J, Visscher
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Nicotinamide Mononucleotide: Exploration of Diverse Therapeutic Applications of a Potential Molecule
Biomolecules, 2019 Nicotinamide mononucleotide (NMN) is a nucleotide that is most recognized for its role as an intermediate of nicotinamide adenine dinucleotide (NAD+) biosynthesis.
Saikat Kumar Poddar, Noor Ahmed Nahid
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Metabolism of nicotinamide mononucleotide in beef liver
Archives of Biochemistry and Biophysics, 1987Nicotinamide mononucleotide (NMN) is not only an intermediate for the biosynthesis but also a degradation product of pyridine cofactors in animal tissues. Among the animal tissues tested, the highest NMN catabolizing activity was detected in beef liver (5.6 mumol/min/g tissue).
T, Imai, B M, Anderson
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Metabolic Engineering, 2021
β-Nicotinamide mononucleotide (NMN) is, one of the nucleotide compounds, a precursor of NAD+ and has recently attracted attention as a nutraceutical. Here, we develop a whole-cell biocatalyst using Escherichia coli, which enabled selective and effective high production of NMN from the inexpensive feedstock substrates glucose and nicotinamide (Nam ...
Shinichiro Shoji +4 more
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β-Nicotinamide mononucleotide (NMN) is, one of the nucleotide compounds, a precursor of NAD+ and has recently attracted attention as a nutraceutical. Here, we develop a whole-cell biocatalyst using Escherichia coli, which enabled selective and effective high production of NMN from the inexpensive feedstock substrates glucose and nicotinamide (Nam ...
Shinichiro Shoji +4 more
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Identification of a novel human nicotinamide mononucleotide adenylyltransferase
Biochemical and Biophysical Research Communications, 2002The enzyme nicotinamide mononucleotide adenylyltransferase is an ubiquitous enzyme catalyzing an essential step in NAD (NADP) biosynthetic pathway. In human cells, the nuclear enzyme, which we will now call NMNAT-1, has been the only known enzyme of this type for over 10 years.
Nadia, Raffaelli +5 more
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Nicotinamide Mononucleotide Adenylyltransferase Activity in Human Erythrocytes
Archives of Biochemistry and Biophysics, 1993Nicotinamide mononucleotide adenylyltransferase (NMN-AT) activity has not hitherto been demonstrated in human red blood cells, owing to its low activity. Since it is usually located in the nucleus, the possibility of finding it in human erythrocytes was excluded.
S, Sestini +3 more
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Establishing a Novel Pathway for the Biosynthesis of Nicotinamide Mononucleotide
Enzyme and Microbial TechnologyNicotinamide mononucleotide (NMN) is a pivotal molecule within the realm of metabolic health, serving as a precursor to nicotinamide adenine dinucleotide (NAD+), a critical coenzyme in cellular energy metabolism. In recent years, the biological production of NMN has garnered significant interest.
Rongchen, Feng +8 more
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