Results 31 to 40 of about 2,780 (117)

Metabolic Signatures of Aging and Gametogenesis in Hydra oligactis

Aging Cell, Volume 25, Issue 8, August 2026.
Hydra oligactis undergoes cold‐induced sexual differentiation and aging, culminating in death. GC–MS‐based metabolite profiling revealed signatures of gametogenesis, for example, polyamine accumulation, and of aging, such as loss of cytoprotection and neurotransmitter function, including taurine depletion.
Nicki Marami‐Zonouz, Erwann Arc, Thomas Roach, Pidder Jansen‐Dürr, Werner Bader, Bert Hobmayer, Ilse Kranner   +6 more
wiley   +1 more source

NAD+ enhancers as therapeutic agents in the cardiorenal axis

Cell Communication and Signaling
Cardiorenal diseases represent a complex interplay between heart failure and renal dysfunction, being clinically classified as cardiorenal syndromes (CRS).
Mariano Marín-Blázquez, Jordi Rovira, María José Ramírez-Bajo, Rubén Zapata-Pérez, Rubén Rabadán-Ros   +4 more
doaj   +1 more source

High‐intensity interval training has a greater effect on metabolic profiles than the dietary composition in male rats

Physiological Reports, Volume 14, Issue 15, August 2026.
High‐intensity interval training (HIIT) induces skeletal muscle metabolic adaptations by modulating amino acid‐related pathways largely independent of dietary fat intake, while under a normal diet it also alters specific glycolytic metabolites, including lactic acid.
Asiyeh Taji Tabas, Marziyeh Saghebjoo, Reza Ghahremani, Mehdi Hedayati   +3 more
wiley   +1 more source

Nicotinamide Reverses the Warburg Effect in CHO Cell Culture

Biotechnology and Bioengineering, Volume 123, Issue 7, Page 1902-1915, July 2026.
ABSTRACT The Warburg effect, the preferential conversion of glucose‐derived pyruvat to lactate despite available oxygen, is a key feature of Chinese hamster ovary (CHO) cell culture. Lactate accumulation in recombinant protein‐producing cell culture is an inefficient usage of glucose, as well as being deleterious to cells.
James Morrissey, Ayca Cankorur‐Cetinkaya, Luigi Grassi, Annie J. Harwood‐Stamper, Jonathan Welsh, Ryte Poskute, Kasia Kozakowska‐McDonnell, Cleo Kontoravdi   +7 more
wiley   +1 more source

Curing Perovskite Photovoltaics With Organic Functional Molecules: Progress, Mechanism, and Prospect

Interdisciplinary Materials, Volume 5, Issue 4, Page 551-572, July 2026.
Leveraging the advantages of precision‐targeted design, excellent chemical stability, diverse geometric configuration, and economic viability, the application of medicinally derived organic functional molecules can accelerate curing multiple problems in perovskite photovoltaics, not only promoting synergistic effects among the functional layers, but ...
Jin Wang, Weihui Bi, Jun Lv, Mengyuan Li, Yanjun Fang, Yingying Xu, Po‐Chuan Yang, Shen Xing, Huichuan Pei, Yufei Zhong   +9 more
wiley   +1 more source

Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers

MedComm, Volume 7, Issue 7, July 2026.
This schematic illustrates the hierarchical and interconnected nature of the primary molecular hallmarks of aging. The progression of aging is driven by a convergence of intrinsic molecular insults. Within the nucleus, genomic instability and telomere attrition trigger persistent DDR, accompanied by extensive epigenetic alterations.
Guowei Cai, Jia Ren, Li Wang, Yingying Wu, Huirui Wang, Xiaomeng Cao, Hao Shang, Xuben Hou, Yujiu Wang, Haibo Xue, Ting Dong   +10 more
wiley   +1 more source

Rapid Human Skin Barrier Disruption by Sodium Dodecyl Sulfate and Associated Molecular Mechanisms

Allergy, Volume 81, Issue 7, Page 2478-2489, July 2026.
Short‐term exposure to SDS rapidly disrupts human skin barrier integrity within minutes, as detected by real‐time electrical impedance spectroscopy. SDS‐induced barrier dysfunction is driven by oxidative stress, leading to suppression of immune/barrier mediators and activation of stress, lipid remodeling, and epidermal differentiation pathways ...
Manru Li, Huseyn Babayev, Paolo D'Avino, Can Zeyneloğlu, Ceren Bicer, Duygu Yazici, Yagiz Pat, Per Svedenhag, Nicolas Gaudenzio, Cezmi A. Akdis, Yasutaka Mitamura   +10 more
wiley   +1 more source

Metabolic Regulation of Immune Responses: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 6, June 2026.
FBP1 loss drives immune evasion and therapy resistance by enhancing glycolysis, STAT3 activation, and PD‐L1 expression, leading to T cell exhaustion and NK cell inhibition. FBP1 restoration, via LNP‐mRNA or epigenetic modulation, reverses these immunosuppressive effects, reactivates cytotoxic T cells, promotes M1 macrophage polarization, and enhances ...
Chunwei Li, Ziqiang Liu, Dezheng Kong, Zhengze Li, Yiming Yan, Yanyu Dong, Lili Zhu, JiaNing Cao, Zhirui Fan, Gautam Sethi, Lifeng Li   +10 more
wiley   +1 more source

The Effectiveness of Four Nicotinamide Adenine Dinucleotide (NAD⁺) Precursors in Alleviating the High-Glucose-Induced Damage to Hepatocytes in Megalobrama amblycephala: Evidence in NAD⁺ Homeostasis, Sirt1/3 Activation, Redox Defense, Inflammatory Response, Apoptosis, and Glucose Metabolism

Antioxidants
The administration of NAD+ precursors is a potential approach to protect against liver damage and metabolic dysfunction. However, the effectiveness of different NAD+ precursors in alleviating metabolic disorders is still poorly elucidated.
Yanzou Dong, Xi Wang, Luyao Wei, Zishang Liu, Xiaoyu Chu, Wei Xiong, Wenbin Liu, Xiangfei Li   +7 more
doaj   +1 more source

Skin Boosters: 2026 Updated

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Skin boosters are increasingly used to improve dermal quality through injectable and device‐assisted approaches; however, definitions and clinical evidence remain heterogeneous. Aims To provide an updated overview and propose a practical classification of skin boosters, including mechanisms, delivery methods, clinical outcomes, and limitations.
Kyu‐ho Yi, Hyunggyu Kang, Jong Keun Song, Olena Sydorchuk, Jeremy B. Green, Hugues Cartier, Roya Zarmehr Zamin, Benjamin Ascher   +7 more
wiley   +1 more source