Results 11 to 20 of about 2,780 (117)

Metabolic dysfunction in human skin: Restoration of mitochondrial integrity and metabolic output by nicotinamide (niacinamide) in primary dermal fibroblasts from older aged donors. [PDF]

Aging Cell, 2020
AbstractAlterations in metabolism in skin are accelerated by environmental stressors such as solar radiation, leading to premature aging. The impact of aging on mitochondria is of interest given their critical role for metabolic output and the finding that environmental stressors cause lowered energy output, particularly in fibroblasts where damage ...
Oblong JE, Bowman A, Rovito HA, Jarrold BB, Sherrill JD, Black MR, Nelson G, Kimball AB, Birch-Machin MA.   +8 more
europepmc   +5 more sources

Topical niacinamide (Nicotinamide) treatment for discoid lupus erythematosus (DLE): A prospective pilot study

Journal of Cosmetic Dermatology, 2023
AbstractBackgroundCutaneous lupus erythematosus is an umbrella term for a group of autoimmune connective tissue disorders affecting the skin. Discoid lupus erythematosus (DLE) is the chronic condition and most common form of cutaneous lupus erythematosus.AimsCurrent therapies of DLE are challenging and not completely satisfactory, highly expensive, off‐
Ahmed H. Nouh, Ahmed R. Elshahid, Ahmed S. Kadah, Youssef A. Zeyada   +3 more
openaire   +2 more sources

The impacts of nicotinamide and inositol on the available cells and product performance of industrial baker's yeasts

Bioresources and Bioprocessing, 2023
A suitable nutrient supply, especially of vitamins, is very significant for the deep display of the inherent genetic properties of microorganisms. Here, using the chemically defined minimal medium (MM) for yeast, nicotinamide and inositol were confirmed ...
Chengpeng Shan, Tianqing Xia, Jiao Liu, Ying Wang, Penggang Bai, Lili Xu, Zailu Li, Jianzhi Zhao, Xiaoming Bao   +8 more
doaj   +1 more source

Scientific Opinion on the safety and efficacy of niacin (nicotinic acid and nicotinamide) as a feed additive for all animal species based on a dossier submitted by Lonza Benelux BV [PDF]

EFSA Journal, 2012
<p>The term ‘niacin’ is used as a generic description of nicotinic acid and nicotinamide with pyridine as the basic structure. Nicotinic acid and nicotinamide function mainly as precursors of the co-enzymes NAD and NADP.
EFSA Panel on Additives and Products or Substances used in Animal Feed
doaj   +1 more source

Scientific Opinion on the safety and efficacy of niacin (nicotinic acid and nicotinamide) as a feed additive for all animal species based on a dossier submitted by Vertellus Specialties Belgium BV [PDF]

EFSA Journal, 2012
<p>The term ‘niacin’ is used as a generic description of nicotinic acid and nicotinamide with pyridine as the basic structure. Nicotinic acid and nicotinamide function mainly as precursors of the co-enzymes NAD and NADP.
EFSA Panel on Additives and Products or Substances used in Animal Feed
doaj   +1 more source

A Mixture of Topical Forms of Polydeoxyribonucleotide, Vitamin C, and Niacinamide Attenuated Skin Pigmentation and Increased Skin Elasticity by Modulating Nuclear Factor Erythroid 2-like 2

Molecules, 2022
It is well-known that increased oxidative stress caused by ultraviolet B (UV-B) radiation induces melanogenesis and activates metalloproteinases (MMPs), which degrade collagen and elastin fibers, leading to decreased skin elasticity.
Hyoung Moon Kim, Kyung-A Byun, Seyeon Oh, Jin Young Yang, Hyun Jun Park, Moon Suk Chung, Kuk Hui Son, Kyunghee Byun   +7 more
doaj   +1 more source

Cystathionine-γ-lyase overexpression modulates oxidized nicotinamide adenine dinucleotide biosynthesis and enhances neovascularization

JVS - Vascular Science, 2023
Objective: Hydrogen sulfide is a proangiogenic gas produced primarily by the transsulfuration enzyme cystathionine-γ-lyase (CGL). CGL-dependent hydrogen sulfide production is required for neovascularization in models of peripheral arterial disease ...
Kevin Kiesworo, MS, Michael R. MacArthur, PhD, Peter Kip, MD, PhD, Thomas Agius, MS, Diane Macabrey, MS, Martine Lambelet, BS, Lauriane Hamard, PhD, C.-Keith Ozaki, MD, James R. Mitchell, PhD, Sébastien Déglise, MD, Sarah J. Mitchell, PhD, Florent Allagnat, PhD, Alban Longchamp, MD, PhD   +12 more
doaj   +1 more source

Potential mechanisms of Lian-Zhi-Fan solution for TNBS-induced ulcerative colitis in rats via a metabolomics approach

Frontiers in Pharmacology, 2022
Lian-Zhi-Fan (LZF) decoction is a hospital-prescribed traditional Chinese medicine botanical drug prepared by the fermentation of decocted Coptidis Rhizome (Huanglian), Gardeniae Fructus (Zhizi), and alum (Baifan).
Junyi Bai, Junyi Bai, Tingting Xiong, Xiao Wang, Yanfen Cheng, Ruifeng Luo, Xiangdong Yang, Chaomei Fu   +7 more
doaj   +1 more source

Review on Biosynthesis of β-Nicotinamide Mononucleotide and Its Derivatives [PDF]

Shipin Kexue
β-Nicotinamide mononucleotide (NMN) is present in all organisms and has attracted widespread attention as a nutritional supplement and pharmaceutical product for the treatment of various diseases, such as Alzheimer’s disease, cancer, aging, and vascular ...
WANG Zhaoying, GUO Xinhao, HUANG Xinhe, CHEN Zhuoyan, LIU Yueqi, LI Juan, CHEN Ning, FAN Xiaoguang
doaj   +1 more source

Neuroprotection of NAD+ and NBP against ischemia/reperfusion brain injury is associated with restoration of sirtuin-regulated metabolic homeostasis

Frontiers in Pharmacology, 2023
Background: Ischemic stroke seriously threatens human health because of high rates of morbidity, mortality and disability. This study compared the effects of nicotinamide adenine dinucleotide (NAD+) and butylphthalide (NBP) on in vitro and in vivo ...
Xin-Xin Wang, Xin-Xin Wang, Guang-Hui Mao, Qi-Qi Li, Jie Tang, Hua Zhang, Kang-Lin Wang, Lei Wang, Hong Ni, Rui Sheng, Zheng-Hong Qin   +10 more
doaj   +1 more source