Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation [PDF]
Antioxidants, 2021 Vitamin B3 (nicotinic acid, niacin) deficiency causes the systemic disease pellagra, which leads to dermatitis, diarrhea, dementia, and possibly death depending on its severity and duration.
Yong Chool Boo, Boo Yong Chool
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An Exploratory Study of Six-Month Niacinamide Supplementation on Macular Structure and Electrophysiology in Primary Open-Angle Glaucoma [PDF]
Vision (Switzerland)Background and Objectives: Primary open-angle glaucoma (POAG) is one of the leading ocular diseases leading to irreversible blindness and is often asymptomatic until advanced cases.
Maria Marinescu +2 more
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Molecules, 2022 Nicotinamide nucleotide transhydrogenase (NNT) is involved in decreasing melanogenesis through tyrosinase degradation induced by cellular redox changes.
Kyunghee Byun +2 more
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Multitargeted Modulation of Skin Dullness by HNHT Formulation: Synergistic Inhibition of Melanogenesis, Glycation, and Lipofuscin Deposition. [PDF]
J Cosmet DermatolABSTRACT Background Skin dullness, characterized by pigmentation disorders and yellowing, is a major cosmetic concern in Asian populations. Lipofuscin exhibits ultraviolet (UV)/visible light spectral absorption, reduces skin reflectance, and contributes to dullness, whereas existing therapies targeting melanogenesis and glycation lack comprehensive ...
Wang Z, Fan Y, Ling P.
europepmc +2 more sources
Nicotinamide (Vitamin B3) Deficiency in Follicular Fluid of Patients With Ovarian Ageing. [PDF]
J Cell Mol MedABSTRACT Nicotinamide is an essential precursor of NAD involved in energy metabolism. A decline in NAD levels across tissues during ageing is well‐documented, and NAD metabolism has been implicated in ovarian ageing. We investigated the relationship between ovarian ageing and the levels of nicotinamide (NAM) and its metabolite 1‐methylnicotinamide (MNA)
Bocca C +5 more
europepmc +2 more sources
AntioxidantsNiacinamide (or nicotinamide) is a small-molecule hydrosoluble vitamin with essential metabolic functions in mammalian cells. Niacinamide has become a key functional ingredient in diverse skincare products and cosmetics. This vitamin plays a pivotal role
Alexis Laurent +2 more
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Niacinamide Antimicrobial Efficacy and Its Mode of Action via Microbial Cell Cycle Arrest
MicroorganismsNiacinamide is a versatile compound widely used in the personal care industry for its ample skin benefits. As a precursor to nicotinamide adenine dinucleotide (NAD+), essential for ATP production and a substrate for poly-ADP-ribose polymerase-1 (PARP-1),
Noa Ziklo
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Improving the in vitro penetration of niacinamide using span 60-based niosomal system in gel formulation [PDF]
Pharmaciana, 2018 Niacinamide is one of the components in cosmeceutical products that have been reported to offer benefits for skin pigmentation, acne, and wrinkles treatment. However, the dermal penetration of niacinamide is poor.
Rise Desnita, Sri Luliana, Zainab
doaj +1 more source
Sirtuins as a potential molecular target of cosmetic ingredients [PDF]
Farmacja Polska, 2022 Sirtuins are a group of enzymes belonging to histone deacetylases. However, they can also catalyze other deacylation reactions (including, for example, demallonylation, desuccinylation or deglutarylation), as well as ADP-ribosylation reactions.
Katarzyna Brezdeń +2 more
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Scientific Opinion on the safety and efficacy of niacin (nicotinamide) as a feed additive for all animal species based on a dossier submitted by EUROPE-ASIA Import Export GmbH [PDF]
EFSA Journal, 2012 <p>The term ‘niacin’ is used as a generic description of nicotinic acid and nicotinamide with pyridine as the basic structure. Nicotinic acid and nicotinamide function mainly as precursors of the co-enzymes NAD and NADP.
EFSA Panel on Additives and Products or Substances used in Animal Feed
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