Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation [PDF]
Antioxidants, 2021 Vitamin B3 (nicotinic acid, niacin) deficiency causes the systemic disease pellagra, which leads to dermatitis, diarrhea, dementia, and possibly death depending on its severity and duration.
Yong Chool Boo
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The Combination of Niacinamide, Vitamin C, and PDRN Mitigates Melanogenesis by Modulating Nicotinamide Nucleotide Transhydrogenase [PDF]
Molecules, 2022 Nicotinamide nucleotide transhydrogenase (NNT) is involved in decreasing melanogenesis through tyrosinase degradation induced by cellular redox changes.
Hyun Jun Park +6 more
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Metabolic dysfunction in human skin: Restoration of mitochondrial integrity and metabolic output by nicotinamide (niacinamide) in primary dermal fibroblasts from older aged donors. [PDF]
Aging Cell, 2020 AbstractAlterations in metabolism in skin are accelerated by environmental stressors such as solar radiation, leading to premature aging. The impact of aging on mitochondria is of interest given their critical role for metabolic output and the finding that environmental stressors cause lowered energy output, particularly in fibroblasts where damage ...
Oblong JE +8 more
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Topical niacinamide (Nicotinamide) treatment for discoid lupus erythematosus (
Journal of Cosmetic Dermatology, 2023 AbstractBackgroundCutaneous lupus erythematosus is an umbrella term for a group of autoimmune connective tissue disorders affecting the skin. Discoid lupus erythematosus (DLE) is the chronic condition and most common form of cutaneous lupus erythematosus.AimsCurrent therapies of DLE are challenging and not completely satisfactory, highly expensive, off‐
Ahmed H. Nouh +3 more
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Scientific Opinion on the safety and efficacy of niacin (nicotinic acid and nicotinamide) as a feed additive for all animal species based on a dossier submitted by Lonza Benelux BV [PDF]
EFSA Journal, 2012 <p>The term ‘niacin’ is used as a generic description of nicotinic acid and nicotinamide with pyridine as the basic structure. Nicotinic acid and nicotinamide function mainly as precursors of the co-enzymes NAD and NADP.
EFSA Panel on Additives and Products or Substances used in Animal Feed
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Heavy metals and arsenic concentrations in water, agricultural soil, and rice in Ngan Son district, Bac Kan province, Vietnam, 2023 This study aimed to develop and validate an HPLC-PDA method for simultaneous quantification of three compounds: nicotinamide mononucleotide (NMN), nicotinic acid, and niacinamide in dietary supplements. The sample preparation procedure was simple, fast, and used environmentally green extracted solvents.
Le Vu Thi Nhat +2 more
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, 2020 Daily exposure of skin to environmental stressors leads to molecular and morphological changes ascribed as premature aging. These stressors include solar radiation, industrial pollution, fossil fuel and carbon emissions, which cause cellular damage that induces an inflammatory response in skin.
John C. Bierman +8 more
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An Exploratory Study of Six-Month Niacinamide Supplementation on Macular Structure and Electrophysiology in Primary Open-Angle Glaucoma [PDF]
VisionBackground and Objectives: Primary open-angle glaucoma (POAG) is one of the leading ocular diseases leading to irreversible blindness and is often asymptomatic until advanced cases.
Constantin Alin Nicola +9 more
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Nicotinamide (Vitamin B3) Deficiency in Follicular Fluid of Patients With Ovarian Ageing. [PDF]
J Cell Mol MedABSTRACT Nicotinamide is an essential precursor of NAD involved in energy metabolism. A decline in NAD levels across tissues during ageing is well‐documented, and NAD metabolism has been implicated in ovarian ageing. We investigated the relationship between ovarian ageing and the levels of nicotinamide (NAM) and its metabolite 1‐methylnicotinamide (MNA)
Bocca C +5 more
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Improving the in vitro penetration of niacinamide using span 60-based niosomal system in gel formulation [PDF]
Pharmaciana, 2018 Niacinamide is one of the components in cosmeceutical products that have been reported to offer benefits for skin pigmentation, acne, and wrinkles treatment. However, the dermal penetration of niacinamide is poor.
Rise Desnita, Sri Luliana, Zainab
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