Results 1 to 10 of about 6,777 (132)

Nicotinamide phosphoribosyltransferase purification using SUMO expression system. [PDF]

Anal Biochem, 2020
Nicotinamide phosphoribosyltransferase (NAMPT) is a rate-limiting enzyme in the salvage pathway required for nicotinamide adenine dinucleotide synthesis. The secreted NAMPT protein serves as a master regulatory cytokine involved in activation of evolutionarily conserved inflammatory networks.
Molugu TR, Oita RC, Chawla U, Camp SM, Brown MF, Garcia JGN.   +5 more
europepmc   +4 more sources

Channeling Nicotinamide Phosphoribosyltransferase (NAMPT) to Address Life and Death. [PDF]

J Med Chem
Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step in NAD+ biosynthesis via salvage of NAM formed from catabolism of NAD+ by proteins with NADase activity (e.g., PARPs, SIRTs, CD38). Depletion of NAD+ in aging, neurodegeneration, and metabolic disorders is addressed by NAD+ supplementation. Conversely, NAMPT inhibitors have
Velma GR, Krider IS, Alves ETM, Courey JM, Laham MS, Thatcher GRJ.   +5 more
europepmc   +3 more sources

Nicotinamide phosphoribosyltransferase inhibitor ameliorates mouse aging-induced cognitive impairment. [PDF]

J Cereb Blood Flow Metab, 2021
Nicotinamide phosphoribosyltransferase (NAMPT) is the key enzyme for the synthesis of nicotinamide adenine dinucleotide (NAD) in the salvaging pathway. Though NAMPT inhibitors such as FK866 were originally developed as anti-cancer drugs, they also display neuroprotective effects. Here we show that the administration of FK866 at 0.5 mg/kg (ip, qod) for
Zeng M, Wei TF, Chen C, Shen C, Gao TY, Xie X, Wu M, Lu YB, Zhang WP.   +8 more
europepmc   +3 more sources

Nicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress. [PDF]

ACS Med Chem Lett
Evidence supports boosting nicotinamide adenine dinucleotide (NAD+) to counteract oxidative stress in aging and neurodegenerative disease. One approach is to enhance the activity of nicotinamide phosphoribosyltransferase (NAMPT). Novel NAMPT positive allosteric modulators (N-PAMs) were identified.
Gordon-Blake J, Ratia K, Weidig V, Velma GR, Ackerman-Berrier M, Penton C, Musku SR, Alves ETM, Driver T, Tai L, Thatcher GRJ.   +10 more
europepmc   +3 more sources

NAMPT (nicotinamide phosphoribosyltransferase) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on NAMPT (nicotinamide phosphoribosyltransferase), with data on DNA, on the protein encoded, and where the gene is implicated.
Koumaki, V, Dalamaga, M
openaire   +2 more sources

Nicotinamide Phosphoribosyltransferase in Human Diseases [PDF]

Journal of Bioanalysis & Biomedicine, 2011
Nicotinamide phosphoribosyltransferase (NAMPT) was first reported as a pre-B-cell colony enhancing factor in 1994 with little notice, but it has received increasing attention in recent years due to accumulating evidence indicating that NAMPT is a pleiotropic protein such as a growth factor, a cytokine, an enzyme and a visfatin.
Zhang, Li, P. Heruth, Daniel, Qing Ye, Shui   +2 more
openaire   +3 more sources

Crystallization of human nicotinamide phosphoribosyltransferase [PDF]

Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2007
In the NAD biosynthetic pathway, nicotinamide phosphoribosyltransferase (NMPRTase; EC 2.4.2.12) plays an important role in catalyzing the synthesis of nicotinamide mononucleotide from nicotinamide and 5'-phosphoribosyl-1'-pyrophosphate. Because the diffraction pattern of the initially obtained crystals was not suitable for structure analysis, the ...
Ryo, Takahashi, Shota, Nakamura, Takuya, Yoshida, Yuji, Kobayashi, Tadayasu, Ohkubo   +4 more
openaire   +2 more sources

Nicotinamide Phosphoribosyltransferase in Malignancy: A Review [PDF]

Genes & Cancer, 2013
Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the rate-limiting step of nicotinamide adenine dinucleotide (NAD) synthesis. Both intracellular and extracellular Nampt (iNampt and eNampt) levels are increased in several human malignancies and some studies demonstrate increased iNampt in more aggressive/invasive tumors and in tumor metastases ...
Rodney E, Shackelford, Kim, Mayhall, Nicole M, Maxwell, Emad, Kandil, Domenico, Coppola   +4 more
openaire   +2 more sources

Recycling Nicotinamide. The Transition-State Structure of Human Nicotinamide Phosphoribosyltransferase [PDF]

Journal of the American Chemical Society, 2013
Human nicotinamide phosphoribosyltransferase (NAMPT) replenishes the NAD pool and controls the activities of sirtuins, mono- and poly-(ADP-ribose) polymerases, and NAD nucleosidase. The nature of the enzymatic transition-state (TS) is central to understanding the function of NAMPT.
Emmanuel S, Burgos, Mathew J, Vetticatt, Vern L, Schramm   +2 more
openaire   +2 more sources

Nicotinamide Phosphoribosyltransferase in Rheumatoid Arthritis [PDF]

Journal of Bioanalysis & Biomedicine, 2011
Nicotinamide Phosphoribosyltransferase (Nampt) is a pleiotropic protein with multiple functions, including catalyzing a rate-limiting reaction of nicotinamide adenine dinucleotide (NAD) synthesis in a mammalian salvage pathway and mediating the innate immune system's inflammatory response.
P. Heruth, Daniel, Zhang, Li, Qing Ye, Shui   +2 more
openaire   +2 more sources