Results 71 to 80 of about 57,446 (263)

PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma

Nature Communications, 2019
Mutations in the Protein Phosphatase PPM1D are oncogenic in certain cancers including diffuse intrinsic pontine glioma (DIPG). Here, the authors show that PPM1D mutations in DIPG induce the silencing of the nicotinic acid phosphoribosyltransferase gene ...
Nathan R. Fons, Ranjini K. Sundaram, Gregory A. Breuer, Sen Peng, Ryan L. McLean, Aravind N. Kalathil, Mark S. Schmidt, Diana M. Carvalho, Alan Mackay, Chris Jones, Ángel M. Carcaboso, Javad Nazarian, Michael E. Berens, Charles Brenner, Ranjit S. Bindra   +14 more
doaj   +1 more source

Study on increase of nicotinamide mononucleotide yield by site-directed mutagenesis of nicotinamide phosphoribosyltransferase [PDF]

Zhongguo niangzao
Nicotinamide phosphoribosyltransferase (NAMPT) was a key rate-limiting enzyme in the biosynthetic pathway of nicotinamide mononucleotide (NMN). In this study, the NAMPT gene derived from Comamonadaceae bacterium was heterologous expressed in Escherichia ...
DONG Ping, XU Yifan, HOU Ying, LUO Xuegang, ZHANG Lin, QIAO Changsheng
doaj   +1 more source

NAD+ metabolism controls inflammation during senescence

Molecular & Cellular Oncology, 2019
We have recently discovered that nicotinamide adenine dinucleotide metabolism controls the pro-inflammatory senescence-associated secretory phenotype during cellular senescence.
Timothy Nacarelli, Rugang Zhang
doaj   +1 more source

Crystal structure of human nicotinic acid phosphoribosyltransferase

FEBS Open Bio, 2015
Nicotinic acid phosphoribosyltransferase (EC 2.4.2.11) (NaPRTase) is the rate‐limiting enzyme in the three‐step Preiss–Handler pathway for the biosynthesis of NAD.
Ada Serena Marletta, Alberto Massarotti, Giuseppe Orsomando, Giulio Magni, Menico Rizzi, Silvia Garavaglia   +5 more
doaj   +1 more source

Silencing of NAMPT leads to up-regulation of insulin receptor substrate 1 gene expression in U87 glioma cells

Endocrine Regulations, 2020
Objective. The aim of the present study was to investigate the effect of adipokine NAMPT (nicotinamide phosphoribosyltransferase) silencing on the expression of genes encoding IRS1 (insulin receptor substrate 1) and some other proliferation related ...
Tsymbal Daria O., Minchenko Dmytro O., Luzina Olena Y., Riabovol Olena O., Danilovskyi Serhiy V., Minchenko Oleksandr H.   +5 more
doaj   +1 more source

Discovery of potential visfatin activators using in silico docking and ADME predictions as therapy for type 2 diabetes

Beni-Suef University Journal of Basic and Applied Sciences, 2018
Visfatin (Nicotinamide phosphoribosyltransferase) is an adipokine implicated in mediating insulin resistance and exhibiting insulin mimetic effect and therefore represents a druggable target for diabetes therapy.
Olusola Olalekan Elekofehinti, Oluwamodupe Cecilia Ejelonu, Jean Paul Kamdem, Oluwaseun Benedicta Akinlosotu, Ayodeji Famuti, Damilare Desmond Adebowale, Opeyemi Iwaloye, Yetunde Irinyemi Bulu, Ige Joseph Kade, Joao Batista Teixeira Rocha   +9 more
doaj   +1 more source

Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase [PDF]

, 2010
Background Inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) are promising cancer drugs currently in clinical trials in oncology, including APO866, CHS-828 and the CHS-828 prodrug EB1627/GMX1777, but cancer cell resistance to these drugs has ...
A Formentini, A Garten, A Nahimana, A Ravaud, AA Sauve, Annemette V Thougaard, Antje Garten, C Lengauer, C Mattos, C Schou, F Nomura, Fredrik Björkling, G Kroemer, GB Kang, GC Elliott, GJ Hageman, GJ Peters, J Diefenbach, J Gullbo, JA Khan, JA Khan, Jakob G Petersen, JB Clark, JR Revollo, JR Revollo, JR Revollo, Jun Yoshino, K Holen, LR Saunders, LS Olsen, M Hasmann, M Pishvaian, M Watson, M Ziegler, Maxwell Sehested, MD Jackson, ME Gorre, ME Gorre, Mette K Christensen, MK Kim, P Hovstadius, P Hovstadius, P Martinsson, PA Janne, PB Jensen, Peter B Jensen, Peter Fristrup, PJ Hjarnaa, SB Hassan, Shin-Ichiro Imai, Søren J Nielsen, T O'Hare, T Wang, U Galli, Uffe H Olesen, UH Olesen, UH Olesen, Wieland Kiess   +57 more
core   +5 more sources

Nicotinamide phosphoribosyltransferase may be involved in age-related brain diseases. [PDF]

PLoS ONE, 2012
Nicotinamide phosphoribosyltransferase (NAMPT) is a key enzyme for nicotinamide adenine dinucleotide (NAD) biosynthesis, and can be found either intracellularly (iNAMPT) or extracellularly (eNAMPT).
Li-Ying Liu, Feng Wang, Xia-Yan Zhang, Peng Huang, Yun-Bi Lu, Er-Qing Wei, Wei-Ping Zhang   +6 more
doaj   +1 more source

Sirtuin 1 in rat orthotopic liver transplantation: An IGL-1 preservation solution approach [PDF]

, 2015
© The Author(s) 2015. AIM: To investigate the possible involvement of Sirtuin 1 (SIRT1) in rat orthotopic liver transplantation (OLT), when Institute Georges Lopez 1 (IGL-1) preservation solution is enriched with trimetazidine (TMZ).
Abdennebi, Hassen B., Bejaoui, Mohamed, Folch-Puy, Emma, Palmeira, Carlos M., Pantazi, Eirini, Rolo, Anabela Pinto, Roselló-Catafau, Joan, Varela, Ana Teresa, Zaouali, Mohamed A.   +8 more
core   +2 more sources

Dietary fatty acids and vitamin B3: an effective treatment strategy for the metabolic syndrome? [PDF]

, 2015
The metabolic syndrome (MS) may be defined as the constellation of cardiovascular disease (CVD) risk factors that comprises obesity, type 2 diabetes, dyslipidemia, and hypertension. Recent evidences suggest that, primarily due to its high monounsaturated
Abia, Rocío, Bermúdez, Beatriz, López, Sergio, Montserrat-de la Paz, Sergio, Muriana, Francisco J. G., Ortega, Almudena, Varela, Lourdes   +6 more
core   +2 more sources