Results 71 to 80 of about 51,366 (193)

Silibinin‐driven microbial and metabolic reprogramming restores CD4+ T cell immunity in HIV immunological nonresponders

VIEW, EarlyView.
Despite efficacious antiretroviral therapy, 10%–40% of HIV‐infected individuals exhibit inadequate immune reconstitution due to persistent inflammatory activation and NAD+ metabolic dysregulation—a critical cofactor in cellular bioenergetics. We administered silibinin to 53 HIV immunological non‐responders and elucidated its mechanism through selective
Wenli Liu, Minghui An, Qi Wang, Yuxin Shang, Shuyao Zang, Haibo Ding, Shuai Fu, Yun Liu, Xue Dong, Xiao Yang, Jinna Dai, Xiaoxu Han, Yingchun Xu, Hong Shang   +13 more
wiley   +1 more source

NAMPT-Mediated NAD+ Biosynthesis Is Essential for Vision In Mice

Cell Reports, 2016
Photoreceptor death is the endpoint of many blinding diseases. Identifying unifying pathogenic mechanisms in these diseases may offer global approaches for facilitating photoreceptor survival.
Jonathan B. Lin, Shunsuke Kubota, Norimitsu Ban, Mitsukuni Yoshida, Andrea Santeford, Abdoulaye Sene, Rei Nakamura, Nicole Zapata, Miyuki Kubota, Kazuo Tsubota, Jun Yoshino, Shin-ichiro Imai, Rajendra S. Apte   +12 more
doaj   +1 more source

Serum Visfatin Level and Cardiac Valve Calcifcation in Hemodialysis Patients

Hemodialysis International, EarlyView.
ABSTRACT Background Cardiac valve calcification is a serious complication in patients with cardiovascular disease. This study investigated the relationship between visfatin levels and cardiac valve calcification in individuals undergoing hemodialysis.
Xiaoqi Wang, Dan Yuan, Feng Shao, Conghui Liu, Xiao Zhang, Zhongxin Li   +5 more
wiley   +1 more source

NAD replenishment restores mitochondrial function and thermogenesis in the brown adipose tissue of mice with obesity

The Journal of Physiology, EarlyView.
Abstract figure legend A high‐fat diet (HFD) induces brown adipose tissue (BAT) whitening, mitochondrial dysfunction (damaged cristae, fragmentation), reduced NAD+ levels and impaired thermogenesis, leading to lower energy expenditure and metabolic inflexibility.
Renata R. Braga, Matheus B. Rocha, Ana P. Morelli, Raul G. da Costa, Marcelo A. S. Mori, Adelino S. R. da Silva, José R. Pauli, Dennys E. Cintra, Eduardo R. Ropelle   +8 more
wiley   +1 more source

Enhancing the anticancer effect of NAMPT inhibition by targeting NAPRT in breast cancer cells

Advances in Cancer Biology - Metastasis
Introduction: Two pathways in the synthesis of NAD, catalyzed by the key enzymes nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosphoribosyltransferase (NAPRT), support constant survival, growth, and propagation of cancer cells.
Zahra Gharedaghi, Parichehr Mehrafshar, Soha Mohammadi, Masoumeh Tavakoli-Yaraki, Pegah Golpour, Mitra Nourbakhsh, Nima Taghizadeh   +6 more
doaj   +1 more source

Molecular responses in abdominal subcutaneous adipose tissue after a session of endurance exercise: effects of exercise intensity

The Journal of Physiology, EarlyView.
Abstract figure legend An acute session of aerobic exercise induces robust transcriptional changes in abdominal subcutaneous adipose tissue 1.5 h after exercise. Exercise at low‐, moderate‐ and high‐intensities each reveals some distinct molecular responses in adipose tissue.
Cheehoon Ahn, Tao Zhang, Thomas Rode, Gayoung Yang, Olivia K. Chugh, Sierra Ellis, Sophia Ghayur, Shriya Mehta, Ryan Salzman, Hui Jiang, Stephen C. J. Parker, Charles F. Burant, Jeffrey F. Horowitz   +12 more
wiley   +1 more source

The Influence of Schwann Cell Metabolism and Dysfunction on Axon Maintenance

Glia, Volume 73, Issue 12, Page 2338-2352, December 2025.
Main Points Sensory neurons depend on Schwann cells for survival. Schwann cells provide energy for axons dunng rapid firing or after injury. Dysregulated metabolism in Schwann cells can lead to the production of neurotoxic and axon degeneration. ABSTRACT Schwann cells are the glial cells in the peripheral nervous system responsible for the production ...
Rose Follis, Vishwanath V. Prabhu, Bruce D. Carter   +2 more
wiley   +1 more source

Risk Factors for Cardiovascular and Metabolic Disease: Integrating Traditional and Novel Paradigms

iNew Medicine, Volume 1, Issue 1, December 2025.
ABSTRACT Cardiovascular and metabolic diseases (CVMD), encompassing atherosclerotic cardiovascular disease (ASCVD), heart failure, obesity, type 2 diabetes mellitus (T2DM), and metabolic dysfunction‐associated steatotic liver disease (MASLD), remain the leading global cause of morbidity and mortality.
Zhihua Wang, Shuo Chen, Suowen Xu, Jianping Weng   +3 more
wiley   +1 more source

Obesity Paradox in Cancer: A Complex Interplay Between Risk and Therapeutic Outcomes

MedComm, Volume 6, Issue 12, December 2025.
This review summarizes how obesity‐driven metabolic and immune alterations contribute to both cancer development and the paradoxical improvement of immunotherapy outcomes. ABSTRACT Obesity is a recognized risk factor for cancer development and progression. Paradoxically, growing clinical evidence across several cancer types indicates that elevated body
Tong Chen, Wenjia Zhai, Jiaao Song, Wenqiang Liu, Zhenjie Wu, Fu Yang, Linhui Wang   +6 more
wiley   +1 more source

Review on Biosynthesis of β-Nicotinamide Mononucleotide and Its Derivatives [PDF]

Shipin Kexue
β-Nicotinamide mononucleotide (NMN) is present in all organisms and has attracted widespread attention as a nutritional supplement and pharmaceutical product for the treatment of various diseases, such as Alzheimer’s disease, cancer, aging, and vascular ...
WANG Zhaoying, GUO Xinhao, HUANG Xinhe, CHEN Zhuoyan, LIU Yueqi, LI Juan, CHEN Ning, FAN Xiaoguang
doaj   +1 more source