Results 81 to 90 of about 30,547 (198)

Safety of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of nicotinamide from this source, in the context of Directive 2002/46/EC

EFSA Journal, 2019
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Allergens (NDA) was asked to deliver an opinion on nicotinamide riboside chloride as a novel food (NF) pursuant to Regulation (EU) 2015/2283, including an ...
EFSA Panel on Nutrition, Novel foods and Food allergens (NDA), Dominique Turck, Jacqueline Castenmiller, Stefaan deHenauw, Karen Ildico Hirsch‐Ernst, John Kearney, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Carmen Pelaez, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri, Marco Vinceti, Francesco Cubadda, Karl‐Heinz Engel, Thomas Frenzel, Marina Heinonen, Rosangela Marchelli, Monika Neuhäuser‐Berthold, Annette Pöting, Morten Poulsen, Yolanda Sanz, Josef Rudolf Schlatter, Henk vanLoveren Agnès de Sesmaisons‐Lecarré, Andrea Germini, Helle Katrine Knutsen   +28 more
doaj   +1 more source

NAD+ biosynthesis, aging, and disease [version 1; referees: 2 approved]

F1000Research, 2018
Nicotinamide adenine dinucleotide (NAD+) biosynthesis and its regulation have recently been attracting markedly increasing interest. Aging is marked by a systemic decrease in NAD+ across multiple tissues.
Sean Johnson, Shin–ichiro Imai
doaj   +1 more source

Epigenetic Changes Associated With a Phenotypic Transition in Namibian Cheetahs

Molecular Ecology, Volume 35, Issue 17, September 2026.
ABSTRACT In populations with low genetic diversity, the capacity to adapt to environmental change is limited. While epigenetic mechanisms can generate phenotypic plasticity, their role in mediating adaptive life‐history transitions in the wild is largely unknown.
Colin Vullioud, Diana Geweiler, Joerg Melzheimer, Sonja Heinrich, Jörns Fickel, Bettina Wachter, Alexandra Weyrich   +6 more
wiley   +1 more source

Extending Cofactor‐Tethered Nanomachines to Complex Multienzyme Redox Cascades in Continuous Flow

ChemSusChem, Volume 19, Issue 15, 14 August 2026.
Engineered enzyme fusions bearing covalently tethered PEG–nicotinamide cofactors enable intramolecular cofactor retention and recycling within self‐sufficient biocatalytic nanomachines. These nanomachines support cofactor‐autonomous operation of complex redox multienzyme cascades under continuous‐flow conditions, as demonstrated in a 10‐step glucose‐to‐
Zinnia Dsouza, Jan‐Simon Jeshua Friedrichs, Okke Melse, Gerhard Schenk, Volker Sieber   +4 more
wiley   +1 more source

β-1,2,3-Triazolyl-nucleosides as nicotinamide riboside mimics

, 2009
The synthesis of a series of pyridine- and piperidine-substituted 1,2,3-triazolides linked to a riboside moiety is described. The presence of a triazolide substituent on the pyridine moiety permitted the facile reduction of the latter under mild ...
Dvorakova, M., Migaud, M.E., Huang, M.; id_orcid, Amigues, E.J., Armstrong, E.   +4 more
core   +1 more source

Dihydronicotinamide riboside promotes cell-specific cytotoxicity by tipping the balance between metabolic regulation and oxidative stress.

PLoS ONE, 2020
Nicotinamide adenine dinucleotide (NAD+), the essential cofactor derived from vitamin B3, is both a coenzyme in redox enzymatic processes and substrate in non-redox events; processes that are intimately implicated in all essential bioenergetics.
Manoj Sonavane, Faisal Hayat, Mikhail Makarov, Marie E Migaud, Natalie R Gassman   +4 more
doaj   +1 more source

The Efficacy of Risk Factor Modification Compared to NAD+ Repletion in Diastolic Heart Failure

JACC: Basic to Translational Science
Summary: Heart failure (HF) with left ventricular diastolic dysfunction is a growing global concern. This study evaluated myocardial oxidized nicotinamide adenine dinucleotide (NAD+) levels in human systolic and diastolic HF and in a murine model of HF ...
Yen Chin Koay, PhD, Ren Ping Liu, BS, Bailey McIntosh, BS, Niv Vigder, BS, Serlin Lauren, BS, Angela Yu Bai, BS, Saki Tomita, BS, Desmond Li, PhD, Dylan Harney, PhD, Benjamin Hunter, PhD, Yunwei Zhang, PhD, Jean Yang, PhD, Paul Bannon, MD, PhD, Ashleigh Philp, PhD, Andrew Philp, PhD, David M. Kaye, MD, PhD, Mark Larance, PhD, Sean Lal, MD, PhD, John F. O’Sullivan, MD, PhD   +18 more
doaj   +1 more source

Nicotinamide riboside, pterostilbene and ibudilast protect motor neurons and extend survival in ALS mice [PDF]

Oxidative stress and neuroinflammation are major contributors to the pathophysiology of ALS. Nicotinamide riboside (a NAD+ precursor) and pterostilbene (a natural antioxidant) were efficacious in a human pilot study of ALS patients and in ALS SOD1G93A ...
Salvador Palmer, M. del Rosario, Estrela Arigüel, José María, Obrador, Elena, Dellinger, Ryan W., Moreno-Murciano, Paz, Oriol-Caballo, María, López-Blanch, Rafael   +6 more
core   +1 more source

The Fluorinated NAD Precursors Enhance FK866 Cytotoxicity by Activating SARM1 in Glioblastoma Cells

Biology
Glioblastoma, a formidable brain tumor characterized by dysregulated NAD metabolism, poses a significant therapeutic challenge. The NAMPT inhibitor FK866, which induces NAD depletion, has shown promise in controlling tumor proliferation and modifying the
Wei Ming He, Jian Yuan Yang, Zhi Ying Zhao, Weimin Xiao, Wan Hua Li, Yong Juan Zhao   +5 more
doaj   +1 more source

Nicotinamide Riboside Ameliorates Hyperpigmentation on Photo-Irradiated Skin

Cosmetics
Nicotinamide adenine dinucleotide (NAD) is one of the most important and essential components within an organism. Extensive ongoing research is aimed at harnessing its potential in managing diverse diseases by supplying various forms of NAD in its ...
Yeon Jae Lee, Seul Gi Jang, Min Jeong Ryu, Seung Hee Choi   +3 more
doaj   +1 more source