Results 71 to 80 of about 30,547 (198)

Chemo-enzymatic synthesis of isotopically labeled nicotinamide riboside

, 2018
A versatile chemo-enzymatic synthesis of isotopically labeled nicotinamide riboside (NR) was developed.
Ryota Yokose, Yana Cen, Ai Tran
core   +1 more source

Metabolic Engineering of Bacillus licheniformis for the Bioproduction of Nicotinamide Riboside from Nicotinamide and Glucose

, 2023
Nicotinamide riboside (NR) is an important nucleotide, a precursor of nicotinamide adenine dinucleotide, that has attracted great attention as a promising nutraceutical to improve various symptoms of diabetes, vascular disease, and age-related ...
Shouwen Chen (3550844), Menglin Zhou (7874144), Haotian Che (15207416), Yangyang Zhan (5948054), Yi Li (1144), Dongbo Cai (3948317), Shan wang (15207419), Yaqi Sun (627064)   +7 more
core   +1 more source

Insulin and glycolysis dependency of cardioprotection by nicotinamide riboside. [PDF]

Basic Res Cardiol
AbstractDecreased nicotinamide adenine dinucleotide (NAD+) levels contribute to various pathologies such as ageing, diabetes, heart failure and ischemia–reperfusion injury (IRI). Nicotinamide riboside (NR) has emerged as a promising therapeutic NAD+ precursor due to efficient NAD+ elevation and was recently shown to be the only agent able to reduce ...
Xiao Y, Wang Q, Zhang H, Nederlof R, Bakker D, Siadari BA, Wesselink MW, Preckel B, Weber NC, Hollmann MW, Schomakers BV, van Weeghel M, Zuurbier CJ.   +12 more
europepmc   +4 more sources

The Role of SIRT1 in Mediating Bone Marrow Edema and Its Interface With Bone Remodeling

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Background Bone marrow edema (BME), a common magnetic resonance imaging (MRI) finding characterized by increased fluid signal, is associated with pain and structural deterioration in conditions such as osteoarthritis and avascular necrosis. The pathophysiology of BME involves a complex interplay of vascular leakage, inflammation, microdamage ...
Yiming Chen, Xinyue Li, Zhongji Zheng, Zhihong Liu, Tao Xu, Yuanyi Tang   +5 more
wiley   +1 more source

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

Nature Communications, 2016
NAD+ is an important coenzyme that mediates cellular metabolism and defends against stresses due to age and overnutrition. Here the authors demonstrate unique bioavailability of the NAD+ precursor vitamin nicotinamide riboside (NR) in mice and humans ...
Samuel A. J. Trammell, Mark S. Schmidt, Benjamin J. Weidemann, Philip Redpath, Frank Jaksch, Ryan W. Dellinger, Zhonggang Li, E. Dale Abel, Marie E. Migaud, Charles Brenner   +9 more
doaj   +1 more source

Tissue‐Resident Macrophage in Inflammation and Cancer

MedComm, Volume 7, Issue 9, September 2026.
Opposing macrophage functions in inflammation and cancer converge on shared mechanistic nodes, informing cross‐disease therapeutic strategies. ABSTRACT Tissue‐resident macrophages (TRMs) are long‐lived immune cells strategically distributed across organs, where their functional plasticity enables both homeostatic maintenance and pathological ...
Siyuan Huang, Jiangbo Fan, Wenyi Liu, Di Liu, Rui Wang, Yuanyang Wang, Jianhui Sun, Huacai Zhang, Qingli Cai, Zhe Xu, Fang Xu, Jianxin Jiang, Zhen Wang, Ling Zeng   +13 more
wiley   +1 more source

Syntheses of Nicotinamide Riboside and Derivatives: Effective Agents for Increasing Nicotinamide Adenine Dinucleotide Concentrations in Mammalian Cells

, 2016
A new two-step methodology achieves stereoselective synthesis of β-nicotinamide riboside and a series of related amide, ester, and acid nucleosides.
Anthony A. Sauve (531222), Tianle Yang (34996), Noel Yan-Ki Chan (2461303)   +2 more
core   +1 more source

Induction of the nicotinamide riboside kinase NAD+ salvage pathway in a model of sarcoplasmic reticulum dysfunction

Skeletal Muscle, 2020
Background Hexose-6-Phosphate Dehydrogenase (H6PD) is a generator of NADPH in the Endoplasmic/Sarcoplasmic Reticulum (ER/SR). Interaction of H6PD with 11β-hydroxysteroid dehydrogenase type 1 provides NADPH to support oxo-reduction of inactive to active ...
Craig L. Doig, Agnieszka E. Zielinska, Rachel S. Fletcher, Lucy A. Oakey, Yasir S. Elhassan, Antje Garten, David Cartwright, Silke Heising, Ahmed Alsheri, David G. Watson, Cornelia Prehn, Jerzy Adamski, Daniel A. Tennant, Gareth G. Lavery   +13 more
doaj   +1 more source

A Mechanism‐Based Framework for Anti‐Aging Strategies: From Metabolic Regulation to Senotherapy and Stem Cell‐Based Interventions

Aging Cell, Volume 25, Issue 9, September 2026.
The aging of the human body is a complex process driven by multiple contributing factors. Based on their underlying mechanisms, current anti‐aging interventions can be classified into six primary categories. This paper summarizes the most promising anti‐aging strategies within each class. ABSTRACT The global prevalence of aging and age‐related diseases
Feifei Li, Yankai Wang, Gelin Wang, Jiguo Chen, Song Huang   +4 more
wiley   +1 more source

Streamlining Design, Engineering, and Applications of Nicotinamide Riboside Kinase for Sustainable Biosynthesis of Nicotinamide Mononucleotide in Flow

, 2023
The market demand for β-nicotinamide mononucleotide (NMN), an antiaging health product, is rapidly expanding. Consequently, there is an urgent requirement for an environment-friendly and economical approach to synthesize NMN.
Ke-Xin Li (12459120), Qian Guo (107009), Feng Cheng, Ya-Ping Xue, Huan Li (120482), Qi Shen, Yu-Guo Zheng, Ya-Ping Xue (427998), Feng Cheng (124653), Yu-Guo Zheng (427999), Xiao-Hu Wu, Huan Li, Ke-Xin Li, Qian Guo, Qi Shen (166827), Xiao-Hu Wu (17109342)   +15 more
core   +1 more source