Results 51 to 60 of about 30,547 (198)

Nicotinamide Mononucleotide: Exploration of Diverse Therapeutic Applications of a Potential Molecule

Biomolecules, 2019
Nicotinamide mononucleotide (NMN) is a nucleotide that is most recognized for its role as an intermediate of nicotinamide adenine dinucleotide (NAD+) biosynthesis.
Saikat Kumar Poddar, Ali Ehsan Sifat, Sanjana Haque, Noor Ahmed Nahid, Sabiha Chowdhury, Imtias Mehedi   +5 more
doaj   +1 more source

Supplemental Material - Preclinical safety assessments of nicotinamide riboside hydrogen malate

, 2022
Supplemental Material for Preclinical safety assessments of nicotinamide riboside hydrogen malate by Margitta Dziwenka and Amy Mozingo in Toxicology Research and ...
Amy Mozingo (12903357), Margitta Dziwenka (11890555)   +1 more
core   +1 more source

Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma

Nature Communications, 2023
Nicotinamide phosphoribosyltransferase (NAMPT) plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear.
Miyuki Nomura, Mai Ohuchi, Yoshimi Sakamoto, Kei Kudo, Keisuke Yaku, Tomoyoshi Soga, Yuki Sugiura, Mami Morita, Kayoko Hayashi, Shuko Miyahara, Taku Sato, Yoji Yamashita, Shigemi Ito, Naohiko Kikuchi, Ikuro Sato, Rintaro Saito, Nobuo Yaegashi, Tatsuro Fukuhara, Hidekazu Yamada, Hiroshi Shima, Keiichi I. Nakayama, Atsushi Hirao, Kenta Kawasaki, Yoichi Arai, Shusuke Akamatsu, Sei-ichi Tanuma, Toshiro Sato, Takashi Nakagawa, Nobuhiro Tanuma   +28 more
doaj   +1 more source

Nicotinamide riboside kinases regulate skeletal muscle fiber-type specification and are rate-limiting for metabolic adaptations during regeneration

Frontiers in Cell and Developmental Biology, 2022
Nicotinamide riboside kinases (NRKs) control the conversion of dietary Nicotinamide Riboside (NR) to NAD+, but little is known about their contribution to endogenous NAD+ turnover and muscle plasticity during skeletal muscle growth and remodeling.
Tanja Sonntag, Tanja Sonntag, Sara Ancel, Sara Ancel, Sonia Karaz, Paulina Cichosz, Guillaume Jacot, Maria Pilar Giner, José Luis Sanchez-Garcia, Alice Pannérec, Sofia Moco, Vincenzo Sorrentino, Carles Cantó, Carles Cantó, Jérôme N. Feige, Jérôme N. Feige   +15 more
doaj   +1 more source

Dihydronicotinamide riboside: synthesis from nicotinamide riboside chloride, purification and stability studies

RSC Advances, 2021
A convenient and scalable method for synthesis of dihydronicotinamide riboside (NRH) from the commercially available nicotinamide riboside chloride (NRCl) is elaborated as well as a fast purification method that led to high purity NRH.
Amin Zarei, Leila Khazdooz, Mojtaba Enayati, Sara Madarshahian, Timothy J. Wooster, Gerhard Ufheil, Alireza Abbaspourrad   +6 more
openaire   +3 more sources

Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+ [PDF]

, 2007
SummaryAlthough NAD+ biosynthesis is required for Sir2 functions and replicative lifespan in yeast, alterations in NAD+ precursors have been reported to accelerate aging but not to extend lifespan.
Racette, Frances G., McClure, Julie M., Smith, Jeffrey S., Bogan, Katrina L., Brenner, Charles, Belenky, Peter   +5 more
core   +1 more source

Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage

Nature Communications, 2019
Nicotinamide adenine dinucleotide (NAD+) sustains cellular energy metabolism, functions as a substrate of Sirt and PARP enzymes, and its supplementation is explored therapeutically in aging and other contexts.
Audrey Sambeat, Joanna Ratajczak, Magali Joffraud, José L. Sanchez-Garcia, Maria P. Giner, Armand Valsesia, Judith Giroud-Gerbetant, Miriam Valera-Alberni, Angelique Cercillieux, Marie Boutant, Sameer S. Kulkarni, Sofia Moco, Carles Canto   +12 more
doaj   +1 more source

BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities

Nature Communications, 2021
Nicotinamide riboside (NR) is a NAD + precursor exhibiting beneficial effects against aging. Here the authors demonstrate that orally administered NR increases NAD + levels in a diphasic manner and that bone marrow stromal cell antigen 1 plays a crucial ...
Keisuke Yaku, Sailesh Palikhe, Hironori Izumi, Tomoyuki Yoshida, Keisuke Hikosaka, Faisal Hayat, Mariam Karim, Tooba Iqbal, Yasuhito Nitta, Atsushi Sato, Marie E. Migaud, Katsuhiko Ishihara, Hisashi Mori, Takashi Nakagawa   +13 more
doaj   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Electrochemical Characterization of Nicotinamide Riboside

ChemElectroChem, 2019
AbstractTo improve quality of life, nicotinamide riboside (NR) has become a go‐to supplement to serve as a precursor to nicotinamide adenine dinucleotide (NAD+/NADH). NAD+ is a cofactor used in various extra‐ and intra‐cellular metabolic pathways by enzymes that maintain physiological functions like vision, hearing, and cognitive behavior ...
Sondrica Goines, Jeffrey E. Dick
openaire   +2 more sources