Results 91 to 100 of about 170,260 (319)
Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application
BMEMat, EarlyView.The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah +9 more
wiley +1 more source
Hot wires and film boiling: Another look at carbonyl formation in electronic cigarettes [PDF]
arXiv, 2020 Electronic cigarettes (ECIGS) are a class of tobacco products that emit a nicotine-containing aerosol by heating and vaporizing a liquid. Apart from initiating nicotine addiction in nonsmokers, a persistent concern about these products is that their emissions often include high levels of carbonyl species, toxicants thought to cause most non-cancer ...
arxiv
An update on nicotine replacement therapy
Journal of Oral Research and Review, 2019 Tobacco use is the single greatest preventable cause of death in the world. Most tobacco users want to quit but find it difficult to stop due to the addictiveness of nicotine. Interventions for tobacco cessation are important in enabling tobacco users to
K A Kamala, S Sankethguddad, S G Sujith
doaj +1 more source
Periodontitis presenting among betel quid users: A case series
Clinical Advances in Periodontics, EarlyView.Abstract Background Betel leaf chewing habit has been studied extensively, as it has been an ancient practice in many Asian countries. Although betel leaf has been reported to have potential beneficial properties, it has also been shown to have a strong association with oral diseases, including periodontitis. This case series addresses the presentation
Jungweon V. Park +2 more
wiley +1 more source
Functional and structural markers of peripheral microvascular autonomic neuropathy
Muscle &Nerve, Volume 67, Issue 2, Page 146-153, February 2023., 2023 Abstract Introduction/Aims Autonomic dysfunction is a common complication of small‐fiber neuropathy (SFN). In this study we aimed to assess the applicability of autonomic microvascular indices as a potential marker for SFN assessment. Methods Fifteen patients with confirmed SFN (idiopathic neuropathy [n = 10], chemotherapy‐induced peripheral neuropathy
Thorsten K. Rasmussen +5 more
wiley +1 more source
Untangling direct and domain-mediated interactions between nicotinic acetylcholine receptors in DHA-rich membranes [PDF]
arXiv, 2019 At the neuromuscular junction (NMJ), the nicotinic acetylcholine receptor (nAChR) self-associates to give rise to rapid muscle movement. While lipid domains have maintained nAChR aggregates in-vitro, their specific roles in nAChR clustering are currently unknown. In the present study, we carried out coarse-grained molecular dynamics simulations (CG-MD)
arxiv
Chronic Diseases and Translational Medicine, EarlyView.Donanemab, approved by the U.S. FDA in July 2024, targets amyloid plaques in the brain to treat Alzheimer's disease in patients with mild cognitive impairment or mild dementia. ABSTRACT Substantial research has been conducted to identify an efficient treatment for Alzheimer's disease (AD).
Nandhini Jayaprakash +1 more
wiley +1 more source
ChemMedChem, Accepted Article.The work presented herein outlines the ongoing structure‐activity relationship (SAR) studies centered around a potent, efficacious, and selective activators of the GIRK1/2 channel. Optimization studies centered around the pyrazole privileged scaffold, the N‐1‐position of the pyrazole and the right‐hand ether.
Sumaiya Nahid +8 more
wiley +1 more source
Scientific Reports, 2020 Smokers who switch completely to e-cigarettes may reduce their relative risk of tobacco-related disease. Effective nicotine delivery from e-cigarettes is important in consumer acceptance.
James K. Ebajemito +5 more
doaj +1 more source