Results 91 to 100 of about 458,722 (380)

Nicotine Reprograms Aging‐Related Metabolism and Protects Against Motor Decline in Mice

Advanced Science, EarlyView.
Long‐term oral nicotine intake protects against age‐related motor decline in mice without eliciting systemic toxicity. Integrated multi‐organ metabolomic profiling and longitudinal gut microbiota analyses reveal that nicotine induces coordinated remodeling of glycolipid and sphingolipid metabolism, enhances NAD⁺ bioavailability, and suppresses ceramide
Shuhui Jia, Xiaoyuan Jing, Ruoxi Wang, Mengke Su, Pei Wang, Yingxin Feng, Xiaohu Ren, Longfang Tu, Ping Wei, Zhen Lu, Yicong Jia, Feng Hong, Zhizhun Mo, Jiemeng Zou, Kang Huang, Caiyun Yan, Qianhui Zou, Liang Wang, Guoping Zhong, Zhi Zeng, Qiuliyang Yu, Wen Su, Xifei Yang, Fan Pan, Jianzhi Wang, Liping Wang, Lijun Kang, Paul J. Kenny, Zuxin Chen, Xin‐an Liu   +29 more
wiley   +1 more source

Impact of a smoking ban in hospitality venues on second hand smoke exposure : a comparison of exposure assessment methods [PDF]

, 2013
In May 2010, Switzerland introduced a heterogeneous smoking ban in the hospitality sector. While the law leaves room for exceptions in some cantons, it is comprehensive in others.
Bauer, Georg F., Hoffmann, Susanne, Huynh, Cong Khanh, Rajkumar, Sarah, Röösli, Martin   +4 more
core   +4 more sources

Activation of Lysosomal Retrograde Transport Triggers TPC1‐IP3R1 Ca2+ Crosstalk at Lysosome‐ER MCSs Leading to Lethal Depleting of ER Calcium

Advanced Science, EarlyView.
The flavonoid compound LW‐213 exerts its antitumor effects through a novel mechanism involving lysosomal‐ER calcium regulation. Specifically, LW‐213 binds to LIMP2, which induces perinuclear clustering of lysosomes and facilitates calcium‐mediated lysosome‐ER interactions.
Meng‐yuan Zhu, Yong‐jian Guo, Yu‐qi Zhu, Hong‐zheng Wang, Hai‐di Wang, Hong‐yu Chen, Yue‐xin Jiang, Hui Li, Hui Hui   +8 more
wiley   +1 more source

Biochemical and genetic biomarkers associated with nicotine dependence in Mexican smokers

Pharmacology Research & Perspectives, 2023
Cigarette smoking remains an important health concern and is still a leading cause of preventable mortality. Nicotine is the substance responsible for sustained tobacco use and dependence.
Gissela Borrego‐Soto, Yadira Xitlalli Perez‐Paramo, Francisco Hernández‐Cabrera, Fatima Miroslaba Alvarado‐Monroy, Gilberto Borrego, Alejandro Robles‐Zamora, Philip Lazarus, Augusto Rojas‐Martinez   +7 more
doaj   +1 more source

Synthetic nicotine e-liquids sold in US online vape shops

Preventive Medicine Reports, 2023
Synthetic nicotine (relative to tobacco-derived, or “natural” nicotine) is an emerging feature of e-cigarettes including e-liquids in the online marketplace. This study investigated a total of 11,161 unique nicotine e-liquids sold in online stores in the
Shaoying Ma, Zefeng Qiu, Jian Chen, Ce Shang   +3 more
doaj   +1 more source

Investigating the impact of nicotine on executive functions using a novel virtual reality assessment [PDF]

, 2012
Aims Nicotine is known to enhance aspects of cognitive functioning in abstinent smokers but the effects on specific areas of executive functions, and in non-smokers are inconclusive.
Al-Adawi, Alcaro, Ashendorf, Benowitz, Dani, Dawkins, Di Matteo, Durrazzo, Edginton, Einstein, Ellis, Evans, Foulds, Friedman, Grant, Heffernan, Heishman, Heishman, Hendricks, Hindmarch, Janhunen, Jansari, Kleykamp, Kumari, Le Houezec, Leventhal, Levin, Miyake, Montgomery, Montgomery, Montgomery, Mumenthaler, Myers, Neumann, Nooyens, Nyberg, Phillips, Pickworth, Poltavski, Powell, Rezvani, Rhodes, Russell, Rusted, Rusted, Rusted, Sabia, Schachter   +47 more
core   +4 more sources

Minimally Invasive Chemical Biopsy Needle with Self‐Wettable Extraction Phase For In Vivo Tissue Sampling During Medical Procedures

Advanced Science, EarlyView.
A new tissue sampling device using an acupuncture needle with bio‐compatible extraction sorbents in the recessed section is developed. The coating material using self‐wettable particles doesn't require solvent activation after sterilization. This device is applied for the anti‐cancer drug concentration monitoring during the in vivo lung perfusion ...
Runshan Will Jiang, Wei Zhou, Marcelo Cypel, Todd L. Demmy, Gal Shafirstein, Guillermo Garza, Emily Gawrys, Joanna Bogusiewicz, Barbara Bojko, Janusz Pawliszyn   +9 more
wiley   +1 more source

Unexpected loss of sensitivity to the nicotinic acetylcholine receptor antagonist activity of mecamylamine and dihydro‐β‐erythroidine in nicotine‐tolerant mice

Brain and Behavior, 2020
Objectives There is a long‐standing interest in developing nicotinic acetylcholine receptor (nAChR) antagonists for concomitant use with nAChR agonists (e.g., nicotine replacement) as complementary smoking cessation aids.
Fernando B. deMoura, Jenny L. Wilkerson, Lance R. McMahon   +2 more
doaj   +1 more source

Effect of Vitamin E on Oocytes Apoptosis in nicotine-treated Mice [PDF]

, 2012
Objective(s): Cigarette and nicotine enhances embryogenesis, fertility, pregnancy loss and ultrastructure alterations of oocyte. This study was performed to determine the effect of daily supplementation of vitamin E on oocytes apoptosis in nicotine ...
Asadi, E., Golalipour, M.J., Jahanshahi, M.   +2 more
core   +1 more source

Chronic electronic cigarette exposure in mice induces features of COPD in a nicotine-dependent manner

Thorax, 2016
Background The use of electronic (e)-cigarettes is increasing rapidly, but their lung health effects are not established. Clinical studies examining the potential long-term impact of e-cigarette use on lung health will take decades.
I. Garcia-Arcos, P. Geraghty, Nathalie Baumlin, Michael A Campos, A. Dabo, B. Jundi, Neville Cummins, E. Eden, A. Grosche, M. Salathe, R. Foronjy   +10 more
semanticscholar   +1 more source