Results 121 to 130 of about 465,225 (381)

Smohaze‐Upregulated RFWD3 Competes with TRIM24 to Stabilize TREX1 and Reduce Cytosolic dsDNA in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
The E3 ubiquitin ligase RFWD3 binds the exonuclease TREX1 and protects it from TRIM24‐mediated ubiquitination and degradation, leading to the eradication of intracellular dsDNA, inhibition of the cGAS‐STING pathway, and immunosuppressive microenvironment of lung cancer.
Xue‐Yan Shi, Yu‐Ke Shen, Meng‐Yao Lv, Yu Sun, Yong‐Fang Lin, Zheng Wang, Xiao‐Liang Jie, Zheng Liu, Yang‐Tong Liu, Yang‐Xin Fu, Zhenhua Ren, Gui‐Zhen Wang, Guang‐Biao Zhou   +12 more
wiley   +1 more source

Comparison of two nicotine dependence measures for use with Korean American Women: The FTND and AUTOS

, 2017
This study compares psychometric properties of the Fagerström Test for Nicotine Dependence (FTND) and Autonomy over Tobacco Scale (AUTOS), which are measures of nicotine dependence.
Kim, Sun S, PhD, APRN-BC
core   +1 more source

Neurophilic Biomimetic Lipoprotein‐Mediated Targeted Nerve Growth Factor Delivery for Traumatic Brain Injury Therapy

Advanced Science, EarlyView.
Design of neurophilic biomimetic lipoprotein for intracerebral delivery of nerve growth factor (NGF) to traumatic brain injury (TBI). Nc‐rHDL@P can cross the BBB through ApoE3‐receptors interaction and target neurons via αRDP‐nAChR interaction. Nc‐rHDL@P delivers NGF to the lesion sites, rescues neurons, curbs inflammation, boosts sensorimotor and ...
Jialin Huang, Wenye Wang, Yidong Peng, Weiji Weng, Hanyu Wei, Qiyuan Feng, Antian Wang, Minjie Hu, Zhuoran Li, Shenyu Sun, Zhenghui He, Daiwen Zhang, Wenlan Qi, Yuhan Han, Zixuan Ma, Jiyuan Hui, Ru Gong, Yingwei Gao, Yong Lin, Jiyao Jiang, Xiaoling Gao, Junfeng Feng   +21 more
wiley   +1 more source

U.S. Physicians’ Views on E-Cigarette Risks and Benefits to Adults Who Smoke Versus Young People Who Do Not Smoke

AJPM Focus
Introduction: Emerging evidence suggests that E-cigarettes are likely less harmful than combustible cigarettes, presenting an opportunity for adults who smoke to quit or switch.
Monica Magalhaes, PhD, Michelle T. Bover Manderski, PhD, MPH, Michelle Jeong, PhD, William J. Young, PhD, Michael B. Steinberg, MD, MPH, Nir Eyal, DPhil   +5 more
doaj   +1 more source

MicroRNA Regulation of nAChR Expression and Nicotine-Dependent Behavior in C. elegans

Cell Reports, 2017
Summary: Chronic exposure to nicotine upregulates nicotinic acetylcholine receptors (nAChRs), and such upregulation is critical for the development of nicotine dependence in humans and animal models.
Manish Rauthan, Jianke Gong, Jinzhi Liu, Zhaoyu Li, Seth A. Wescott, Jianfeng Liu, X.Z. Shawn Xu   +6 more
doaj   +1 more source

GLP-1 acts on habenular avoidance circuits to control nicotine intake

Nature Neuroscience, 2017
Tobacco smokers titrate their nicotine intake to avoid its noxious effects, sensitivity to which may influence vulnerability to tobacco dependence, yet mechanisms of nicotine avoidance are poorly understood.
L. Tuesta, Zuxin Chen, Alexander Duncan, C. Fowler, Masago Ishikawa, Brian R. Lee, Xin-an Liu, Qun Lu, M. Cameron, M. R. Hayes, Theodore M. Kamenecka, Matthew Pletcher, P. Kenny   +12 more
semanticscholar   +1 more source

Prevalence of Overnight Work (1 a.m. to 5 a.m.) Among United States Workers

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background Many factors have resulted in the normalization of nonstandard work schedules in recent decades, including globalization requiring working across time zones and growing demands for goods and services. This paper provides national estimates of overnight work in the USA.
Imelda S. Wong, Toni Alterman, Beverly M. Hittle, Raquel Velazquez‐Kronen, I‐Chen Chen   +4 more
wiley   +1 more source

The Multifaceted Etiology of Mental Disorders With a Focus on Trace Elements, a Review of Recent Literature

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Mental disorders are a significant global public health concern, affecting nearly one in eight individuals worldwide. This review investigates the multifaceted etiology of mental disorders—specifically major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD)—through genetic, neurobiological, and environmental ...
Maria Francesca Astorino, Marco Calabrò, Carmenrita Infortuna, Maria Rosaria Anna Muscatello, Silvana Briuglia, Nicola Cicero, Chiara Fabbri, Alessandro Serretti, Concetta Crisafulli   +8 more
wiley   +1 more source

N‐Amino Peptide–Graphene Quantum Dot Loaded Small Extracellular Vesicles for Targeted Therapy of Tauopathies

Advanced NanoBiomed Research, EarlyView.
A neuron‐targeting drug delivery system is developed by incorporating the tau‐specific N‐amino peptide, mxyl‐NAP2, with graphene quantum dots (GQDs) and encapsulating the complex into small extracellular vesicles functionalized with a neuron‐targeting ligand.
Runyao Zhu, Gaeun Kim, Benjamin H. Rajewski, Isaac J. Angera, Juan R. Del Valle, Yichun Wang   +5 more
wiley   +1 more source

Chronic Nicotine Selectively Enhances α4β2* Nicotinic Acetylcholine Receptors in the Nigrostriatal Dopamine Pathway [PDF]

, 2009
These electrophysiological experiments, in slices and intact animals, study the effects of in vivo chronic exposure to nicotine on functional α4β2* nAChRs in the nigrostriatal dopaminergic (DA) pathway.
Cai, Haijiang, Lester, Henry A., McIntosh, J. Michael, McKinney, Sheri, Nashmi, Raad, Xiao, Cheng   +5 more
core