Results 61 to 70 of about 170,260 (319)

Alpha7 nicotinic acetylcholine receptor signaling modulates ovine fetal brain astrocytes transcriptome in response to endotoxin [PDF]

Front. Immunol. 2019, 2018
Neuroinflammation in utero may result in lifelong neurological disabilities. Astrocytes play a pivotal role, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential of astrocytes. We hypothesized that agonism on alpha7 nicotinic acetylcholine receptor (alpha7nAChR) in fetal astrocytes
arxiv   +1 more source

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

Dissolution Testing of Nicotine Release from OTDN Pouches: Product Characterization and Product-to-Product Comparison

Separations, 2021
In recent years, oral tobacco-derived nicotine (OTDN) pouches have emerged as a new oral tobacco product category. They are available in a variety of flavors and do not contain cut or ground tobacco leaf.
Fadi Aldeek, Nicholas McCutcheon, Cameron Smith, John H. Miller, Timothy L. Danielson   +4 more
doaj   +1 more source

Photonic Nanomaterials for Wearable Health Solutions

Advanced Materials, EarlyView.
This review discusses the fundamentals and applications of photonic nanomaterials in wearable health technologies. It covers light‐matter interactions, synthesis, and functionalization strategies, device assembly, and sensing capabilities. Applications include skin patches and contact lenses for diagnostics and therapy. Future perspectives emphasize AI‐
Taewoong Park, Jung Woo Leem, Young L. Kim, Chi Hwan Lee   +3 more
wiley   +1 more source

Chemical composition of kabuli and desi chickpea (Cicer arietinum L.) cultivars grown in Xinjiang, China

Food Science &Nutrition, Volume 11, Issue 1, Page 236-248, January 2023., 2023
Chemical compositions such as protein, fat, ash, moisture, starch, vitamin B1 and mineral, as well as amino acids and fatty acids were determined in kabuli and desi chickpea species. Forty‐six types of flavonoids in Muying‐1 chickpea were analyzed with UPLC‐QqQ‐MS method.
Shiqi Xiao, Zhenglei Li, Keqiang Zhou, Yinghua Fu   +3 more
wiley   +1 more source

Animal models of nicotine exposure: relevance to second-hand smoking, electronic cigarette use and compulsive smoking

Frontiers in Psychiatry, 2013
Much evidence indicates that individuals use tobacco primarily to experience the psychopharmacological properties of nicotine and that a large proportion of smokers eventually become dependent on nicotine.
Ami eCohen, Olivier eGeorge
doaj   +1 more source

A weighted U statistic for association analysis considering genetic heterogeneity [PDF]

, 2015
Converging evidence suggests that common complex diseases with the same or similar clinical manifestations could have different underlying genetic etiologies. While current research interests have shifted toward uncovering rare variants and structural variations predisposing to human diseases, the impact of heterogeneity in genetic studies of complex ...
arxiv   +1 more source

Life's Essential 8 and midlife trajectories in cognition and brain health: The CARDIA study

Alzheimer's &Dementia, EarlyView.
Abstract INTRODUCTION Poor cardiovascular health (CVH) is linked to Alzheimer's disease and dementia; however, its association with neurocognitive trajectories earlier in life remains underexplored. METHODS We included 3224 participants with information on CVH at early midlife (mean age 45.0 ± standard deviation 3.4) an cognitive assessments, and ...
Christina Silvia Dintica, Xiaqing Jiang, Lenore J. Launer, R. Nick Bryan, Kristine Yaffe   +4 more
wiley   +1 more source

Biochemical and genetic biomarkers associated with nicotine dependence in Mexican smokers

Pharmacology Research & Perspectives, 2023
Cigarette smoking remains an important health concern and is still a leading cause of preventable mortality. Nicotine is the substance responsible for sustained tobacco use and dependence.
Gissela Borrego‐Soto, Yadira Xitlalli Perez‐Paramo, Francisco Hernández‐Cabrera, Fatima Miroslaba Alvarado‐Monroy, Gilberto Borrego, Alejandro Robles‐Zamora, Philip Lazarus, Augusto Rojas‐Martinez   +7 more
doaj   +1 more source

Technology-Enabled Collaborative Care for Type-2 Diabetes and Mental Health (TECC-D): Findings From a Mixed Methods Feasibility Trial of a Responsive Co-Designed Virtual Health Coaching Intervention

International Journal of Integrated Care
Introduction: Type-2 diabetes (T2D) is a complex chronic condition associated with a lower quality of life due to disease specific distress. While there is growing support for personalized diabetes programs, care for mental health challenges is often ...
Diana Sherifali, Carly Whitmore, Farooq Naeem, Osnat C. Melamed, Rosa Dragonetti, Erika Kouzoukas, Jennifer Marttila, Frank Tang, Elise Tanzini, Seeta Ramdass, Peter Selby   +10 more
doaj   +1 more source