Results 61 to 70 of about 265,934 (241)

Analyzing the genes related to nicotine addiction or schizophrenia via a pathway and network based approach

Scientific Reports, 2018
The prevalence of tobacco use in people with schizophrenia is much higher than in general population, which indicates a close relationship between nicotine addiction and schizophrenia.
Ying Hu, Zhonghai Fang, Yichen Yang, Dekai Rohlsen-Neal, Feng Cheng, Ju Wang   +5 more
doaj   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Links between intake of ethanol and nicotine and reward-related mechanisms [PDF]

, 1997
1. Examination was made of the effects of housing conditions on the preference of mice for dilute ethanol or water in a two-bottle choice. Isolating mice from groups of five after 10 days significantly increased their ethanol preference, compared to mice
Bermingham, Mara Roisin Laura
core  

Carryover effects to addiction-associated stimuli in a group of marijuana and cocaine users [PDF]

, 2010
Addiction has been characterized as an attentional bias towards drug-related cues. In two experiments we investigate the effects of non-words that have been associatively trained to addiction-related images in a group of marijuana and cocaine users ...
Money, Sharon, Sharma, Dinkar
core   +1 more source

Factors determining working longevity of medical professionals and ways ofcorrection within the framework of the National Project «Health»

Бюллетень сибирской медицины, 2007
The paper studies the prevalence of nicotine and alcohol addiction and the attitude to work among doctors, medical professionals, and students. Possible methods of prevention of nicotine addiction are described.
S. A. Babanov
doaj   +1 more source

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

Advanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang, Ziting Zhou, Nannan Xue, Jiasi Deng, Yuanyuan Zhou, Xinying Lv, Yuxuan Wang, Yi Zhang, Haotian Pan, Geyan Xu, Yinkun Tao, Mengran Li, Xin Cui, Hongyue Ma, Qian Wang, Zhigang Lu   +15 more
wiley   +1 more source

Internet gaming addiction: current perspectives [PDF]

, 2013
Daria J KussPsychology Research and Behavior Management, Birmingham City University, Birmingham, UKAbstract: In the 2000s, online games became popular, while studies of Internet gaming addiction emerged, outlining the negative consequences of excessive ...
Kuss, DJ, Daria J Kuss, Kuss, D.J., Kuss DJ   +3 more
core   +1 more source

Nicotine and e-cigarettes addiction [PDF]

, 2020
Tobacco use claims more than 8 million lives annually, with most tobacco-related deaths occurring in low and middle-income countries. Second-hand tobacco smoke contributes to an additional 1.2 million deaths annually due to heart disease, cancer, and ...
Ahmad Basri, Nadzirah, Abdul Rahman Ahmad Badayai, Ahmad Badayai, Abdul Rahman, Essau, Cecilia; id_orcid, Cecilia A. Essau, Wahab, Suzaily, Nadzirah Ahmad Basri, Essau, Cecilia A., Suzaily Wahab   +8 more
core   +1 more source

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee, Gayeon Kim, Ellison R. Black, Seonil Kim   +3 more
wiley   +1 more source

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

Advanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu, Yuwu Chen, Wei Meng, Biyi Xu, Junke Mou, Xiaolin Liu, Mengyang Wang, Qishuo Gu, Qianhui Sun, Man Li, Chen Zhao, Ming Zeng, Ying Lv, Boling Yi, Sheng Qu, Xiaoxuan Bai, Ji Li, Xing Luo, Sining Hu, Bo Yu, Haibo Jia   +20 more
wiley   +1 more source