Results 71 to 80 of about 265,934 (241)

The orexin system and nicotine addiction: preclinical insights [PDF]

, 2019
Current pharmacotherapies for smoking have only modest efficacy with failure rates of up to 90%. One potential target for new pharmacotherapies is the orexin/hypocretin system, a hypothalamic neuropeptide system involved in arousal, appetite and reward ...
Khoo, Shaun, McNally, Gavan, Kelly J. Clemens, Clemens, Kelly ; https://orcid.org/, Gavan P. McNally, Khoo, S ; https://orcid.org/, McNally, Gavan ; https://orcid.org/, Shaun Yon-Seng Khoo, Clemens, Kelly   +8 more
core   +1 more source

Remission of Food Addiction Does Not Induce Cross-Addiction after Sleeve Gastrectomy and Gastric Bypass: A Prospective Cohort Study

Obesity Facts, 2020
Background: The hypothesis of “cross-addiction” has never been validated, and numerous aspects speak against it. Objectives: To compare the differences between sleeve gastrectomy (SG) and gastric bypass (GB) procedures concerning cross-addiction. Setting:
Sonja Chiappetta, Christine Stier, Mohamed Ajan Hadid, Nina Malo, Sophia Theodoridou, Rudolf Weiner, Sylvia Weiner   +6 more
doaj   +1 more source

One‐Year Healthcare Utilization and Costs After Emergency Department Encounters for Uncomplicated Appendicitis: A Statewide Observational Study

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Objective Non‐operative management with antibiotics has emerged as an alternative to appendectomy for uncomplicated appendicitis. This study compared one‐year healthcare costs and utilization outcomes after operative versus non‐operative management of uncomplicated appendicitis using statewide administrative data.
Andrew C. Meltzer, Michael Makutonin, Taylor Gorak, Aditya Loganathan, Jack A. Meltzer, Avi Dor   +5 more
wiley   +1 more source

Transitioning to nonpunitive school policies for addressing student substance use: Qualitative interviews with key school administrators

American Journal of Community Psychology, EarlyView.
Abstract Recent policy change in Massachusetts encourages schools to limit their use of exclusionary discipline to “extraordinary circumstances,” but little work has explored the opportunities and challenges of transitioning to nonpunitive practices after student substance use infractions in schools.
Kristina Conroy, M. Grace Albright, Kendall B. Roberts, Meghan A. Costello, Anthony J. Jannetti, Alexis R. Wing, Randi M. Schuster   +6 more
wiley   +1 more source

Insight into nicotine addiction

CHRISMED Journal of Health and Research, 2017
The emergence of the epidemic of nicotine addiction in India and other nations is a global public health tragedy of untoward proportions. Smoking or chewing tobacco can seriously affect general, as well as oral health.
Sahil Handa, Haneet Kour, Charu Khurana
doaj   +1 more source

Adipose‐derived mesenchymal stem cell injection into the KI10 acupoint mitigates cartilage damage in KOA rats through PGE2‐mediated α7nAChR/NF‐κB pathway

Animal Models and Experimental Medicine, EarlyView.
In our research, KOA rat models were established and treated with ADSC injection into the KI10 acupoint. Pain relief, behavioral function, and joint structural improvements were systematically assessed using ethological tests, imaging, histopathological staining, transmission electron microscopy, and molecular analyses.
Mengwei Dong, Wenfang Li, Wanpeng Yang, Te Ba, Nan Nan, Yang Liu, Jing Han, Huiqin Hao   +7 more
wiley   +1 more source

Trial protocol and preliminary results for a cluster randomised trial of behavioural support versus brief advice for smoking cessation in adolescents [PDF]

, 2010
Background: Many young people report they want to stop smoking and have tried to do so, but most of their quit attempts fail. For adult smokers, there is strong evidence that group behavioural support enhances quit rates.
Markham, Wolfgang A., Aveyard Paul, Alan Stanton, Aveyard, P, Stanton, Alan, Paul Aveyard, Bridle Christopher, Gillian Grimshaw, Markham, WA, Wolfgang A Markham, Markham Wolfgang A, Bridle, Christopher, Bridle, C, Grimshaw Gillian, Grimshaw, G. M., Stanton, A, Stanton Alan, Grimshaw, G, Christopher Bridle, Aveyard, Paul   +19 more
core   +1 more source

Reframing the Gut–Brain Axis: The Gut Wall as a Neural Immune Interface in Multiple Sclerosis and Autoimmune Neurological Diseases

Annals of Neurology, EarlyView.
Gut wall physiology in multiple sclerosis (MS) and autoimmune neurologic diseases remains underexplored but may span gut barrier dysfunction, enteric glial targeting, mucosal immune dysregulation, and autoimmune targets within the enteric nervous system (ENS).
Federico Montini, Sean J. Pittock, Laura Cacciaguerra, Howard L. Weiner, Luke A. Schwerdtfeger   +4 more
wiley   +1 more source

Comprehensive Characterization of Acer truncatum Leaf Extract: Identification of Systemic Metabolites and Effects on Performance, Antioxidant Status, and Intestinal Microbiota in Laying Hens

Animal Research and One Health, EarlyView.
Dietary A. truncatum leaf extract is absorbed and improves laying performance in aged hens by enhancing systemic antioxidant capacity and modulating the gut microbiota. ABSTRACT The demand for natural feed additives is considerably increasing in the antibiotic‐free feed era.
Kailong Qin, Jiantao Yang, Minglu Gao, Xiaozhao Tao, Xin Yang, Yanli Liu, Xiaojun Yang   +6 more
wiley   +1 more source

Not so Cool? Menthol’s discovered actions on the nicotinic receptor and its implications for nicotine addiction

Frontiers in Pharmacology, 2013
Nicotine cigarette smoke is a large public health burden worldwide, contributing to various types of disease. Anti-tobacco media campaigns and control programs have significantly reduced smoking in the United States, yet trends for menthol cigarette ...
Nadine eKabbani
doaj   +1 more source