Results 11 to 20 of about 205,287 (293)

Structure and gating mechanism of the α7 nicotinic acetylcholine receptor.

Cell, 2021
The α7 nicotinic acetylcholine receptor plays critical roles in the central nervous system and in the cholinergic inflammatory pathway. This ligand-gated ion channel assembles as a homopentamer, is exceptionally permeable to Ca2+, and desensitizes faster
C. Noviello, A. Gharpure, N. Mukhtasimova, R. Cabuco, Leah Baxter, D. Borek, S. Sine, R. Hibbs   +7 more
semanticscholar   +1 more source

Nicotinic acetylcholine receptors and nicotine addiction: A brief introduction.

Neuropharmacology, 2020
Nicotine is a highly addictive drug found in tobacco that drives its continued use despite the harmful consequences. The initiation of nicotine abuse involves the mesolimbic dopamine system, which contributes to the rewarding sensory stimuli and ...
Ruthie E. Wittenberg, S. Wolfman, Mariella De Biasi, J. Dani   +3 more
semanticscholar   +1 more source

Nicotine Withdrawal [PDF]

, 2015
An aversive abstinence syndrome manifests 4-24 h following cessation of chronic use of nicotine-containing products. Symptoms peak on approximately the 3rd day and taper off over the course of the following 3-4 weeks. While the severity of withdrawal symptoms is largely determined by how nicotine is consumed, certain short nucleotide polymorphisms ...
Ian, McLaughlin, John A, Dani, Mariella, De Biasi   +2 more
openaire   +2 more sources

RgIA4 Potently Blocks Mouse α9α10 nAChRs and Provides Long Lasting Protection against Oxaliplatin-Induced Cold Allodynia

Frontiers in Cellular Neuroscience, 2017
Transcripts for α9 and α10 nicotinic acetylcholine receptor (nAChR) subunits are found in diverse tissues. The function of α9α10 nAChRs is best known in mechanosensory cochlear hair cells, but elsewhere their roles are less well-understood.
Sean B. Christensen, Arik J. Hone, Isabelle Roux, Julie Kniazeff, Jean-Philippe Pin, Grégory Upert, Denis Servent, Elisabeth Glowatzki, Elisabeth Glowatzki, J. Michael McIntosh, J. Michael McIntosh, J. Michael McIntosh   +11 more
doaj   +1 more source

X-ray structure of the human α4β2 nicotinic receptor

Nature, 2016
Nicotinic acetylcholine receptors are ligand-gated ion channels that mediate fast chemical neurotransmission at the neuromuscular junction and have diverse signalling roles in the central nervous system. The nicotinic receptor has been a model system for
C. L. Morales-Pérez, C. Noviello, R. Hibbs   +2 more
semanticscholar   +1 more source

Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands

eLife, 2022
Nicotinic partial agonists provide an accepted aid for smoking cessation and thus contribute to decreasing tobacco-related disease. Improved drugs constitute a continued area of study. However, there remains no reductionist method to examine the cellular
Aaron L Nichols, Zack Blumenfeld, Chengcheng Fan, Laura Luebbert, Annet EM Blom, Bruce N Cohen, Jonathan S Marvin, Philip M Borden, Charlene H Kim, Anand K Muthusamy, Amol V Shivange, Hailey J Knox, Hugo Rego Campello, Jonathan H Wang, Dennis A Dougherty, Loren L Looger, Timothy Gallagher, Douglas C Rees, Henry A Lester   +18 more
doaj   +1 more source

Exposure to Kynurenic Acid during Adolescence Increases Sign-tracking and Impairs Long-term Potentiation in Adulthood

Frontiers in Behavioral Neuroscience, 2015
Changes in brain reward systems are thought to contribute significantly to the cognitive and behavioral impairments of schizophrenia, as well as the propensity to develop co-occurring substance abuse disorders.
Nicole eDeAngeli, Travis eTodd, Stephen eChang, Hermes eYeh, Pamela eYeh, David John Bucci   +5 more
doaj   +1 more source

Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium

Journal of Neuroscience, 1993
A full-length clone coding for the rat alpha 7 nicotinic receptor subunit was isolated from an adult brain cDNA library and expressed in Xenopus oocytes. A significant proportion of the current through alpha 7-channels is carried by Ca2+.
Philippe, Sbgu, Jacques, Wadiche, Kelly, Dineley-Miller, John, A. Dani, James, W., Patrick   +10 more
semanticscholar   +1 more source

Confirming a Role for α9nAChRs and SK Potassium Channels in Type II Hair Cells of the Turtle Posterior Crista

Frontiers in Cellular Neuroscience, 2017
In turtle posterior cristae, cholinergic vestibular efferent neurons (VENs) synapse on type II hair cells, bouton afferents innervating type II hair cells, and afferent calyces innervating type I hair cells.
Xiaorong Xu Parks, Donatella Contini, Paivi M. Jordan, Joseph C. Holt, Joseph C. Holt, Joseph C. Holt   +5 more
doaj   +1 more source

Nicotine's Allure [PDF]

Neuron, 2009
Both conscious and unconscious memory mechanisms contribute to the rewarding effects of nicotine and other drugs of abuse. In this issue of Neuron, Tang and Dani use in vivo measures of synaptic plasticity in freely moving mice to link nicotine-induced dopamine release in hippocampus to LTP induction and behavioral reinforcement.
openaire   +2 more sources