Results 11 to 20 of about 329,742 (333)

A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications.

Comptes rendus. Biologies, 2020
SARS-CoV-2 epidemics raises a considerable issue of public health at the planetary scale. There is a pressing urgency to find treatments based upon currently available scientific knowledge.
J. Changeux, Z. Amoura, F. Rey, M. Miyara   +3 more
semanticscholar   +1 more source

The distribution of charged amino acid residues and the Ca(2+) permeability of nicotinic acetylcholine receptors: a predictive model [PDF]

, 2017
Nicotinic acetylcholine receptors (nAChRs) are cation-selective ligand-gated ion channels exhibiting variable Ca(2+) permeability depending on their subunit composition.
Fucile, Sergio
core   +1 more source

Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors

Current Neuropharmacology, 2018
Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cys-loop ligand-gated ion chan-nels that respond to endogenous acetylcholine (ACh) or other cholinergic ligands.
M. Zoli, Susanna Pucci, A. Vilella, C. Gotti   +3 more
semanticscholar   +1 more source

Exposure to Kynurenic Acid during Adolescence Increases Sign-tracking and Impairs Long-term Potentiation in Adulthood

Frontiers in Behavioral Neuroscience, 2015
Changes in brain reward systems are thought to contribute significantly to the cognitive and behavioral impairments of schizophrenia, as well as the propensity to develop co-occurring substance abuse disorders.
Nicole eDeAngeli, Travis eTodd, Stephen eChang, Hermes eYeh, Pamela eYeh, David John Bucci   +5 more
doaj   +1 more source

Alpha9 nicotinic acetylcholine receptors and the treatment of pain [PDF]

, 2009
Chronic pain is a vexing worldwide problem that causes substantial disability and consumes significant medical resources. Although there are numerous analgesic medications, these work through a small set of molecular mechanisms.
Absalom, Nathan, Chebib, Mary, Elgoyhen, Ana Belen, McIntosh, J. Michael, Vincler, Michelle   +4 more
core   +1 more source

X-ray structure of the human α4β2 nicotinic receptor

Nature, 2016
Nicotinic acetylcholine receptors are ligand-gated ion channels that mediate fast chemical neurotransmission at the neuromuscular junction and have diverse signalling roles in the central nervous system. The nicotinic receptor has been a model system for
C. L. Morales-Pérez, C. Noviello, R. Hibbs   +2 more
semanticscholar   +1 more source

Confirming a Role for α9nAChRs and SK Potassium Channels in Type II Hair Cells of the Turtle Posterior Crista

Frontiers in Cellular Neuroscience, 2017
In turtle posterior cristae, cholinergic vestibular efferent neurons (VENs) synapse on type II hair cells, bouton afferents innervating type II hair cells, and afferent calyces innervating type I hair cells.
Xiaorong Xu Parks, Donatella Contini, Paivi M. Jordan, Joseph C. Holt, Joseph C. Holt, Joseph C. Holt   +5 more
doaj   +1 more source

Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands

eLife, 2022
Nicotinic partial agonists provide an accepted aid for smoking cessation and thus contribute to decreasing tobacco-related disease. Improved drugs constitute a continued area of study. However, there remains no reductionist method to examine the cellular
Aaron L Nichols, Zack Blumenfeld, Chengcheng Fan, Laura Luebbert, Annet EM Blom, Bruce N Cohen, Jonathan S Marvin, Philip M Borden, Charlene H Kim, Anand K Muthusamy, Amol V Shivange, Hailey J Knox, Hugo Rego Campello, Jonathan H Wang, Dennis A Dougherty, Loren L Looger, Timothy Gallagher, Douglas C Rees, Henry A Lester   +18 more
doaj   +1 more source

Arachidonic Acid as a Possible Negative Feedback Inhibitor of Nicotinic Acetylcholine Receptors on Neurons [PDF]

, 1995
Neuronal acetylcholine receptors, being highly permeable to calcium, are likely to regulate calcium-dependent events in neurons. Arachidonic acid is a membrane-permeant second messenger that can be released from membrane phospholipids by phospholipases ...
Berg, Darwin K., Blumenthal, Edward M, Huang, Bo, Vijayaraghavan, Sukumar   +3 more
core   +2 more sources

Structural principles of distinct assemblies of the human α4β2 nicotinic receptor

Nature, 2018
Fast chemical communication in the nervous system is mediated by neurotransmitter-gated ion channels. The prototypical member of this class of cell surface receptors is the cation-selective nicotinic acetylcholine receptor.
R. M. Walsh, S. Roh, A. Gharpure, C. L. Morales-Pérez, J. Teng, R. Hibbs   +5 more
semanticscholar   +1 more source