Results 91 to 100 of about 79,918 (320)

Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants [PDF]

, 2017
We present a framework for computing the gating properties of ligand-gated ion channel mutants using the Monod-Wyman-Changeux (MWC) model of allostery. We derive simple analytic formulas for key functional properties such as the leakiness, dynamic range,
Einav, Tal, Phillips, Rob
core   +4 more sources

Unique nicotinic responses are present in distinct subtypes of mouse medial prefrontal layer V pyramidal neurons

Scientific Reports
The neurotransmitter acetylcholine supports goal-directed cognitive functions via activation of its nicotinic and muscarinic classes of receptors within the prefrontal cortex.
Ashutosh V. Patel, Anthony Nguyen, Ashley A. Geremia, Donia Zeng, Pietro Paletta, Elena Choleris, Craig D. C. Bailey   +6 more
doaj   +1 more source

Structures of highly flexible intracellular domain of human α7 nicotinic acetylcholine receptor

Nature Communications, 2022
The intracellular domain (ICD) of Cys-loop receptors mediates many of their functions, but no complete structure of a Cys-loop receptor ICD is available to date.
Vasyl Bondarenko, Marta M. Wells, Qiang Chen, Tommy S. Tillman, Kevin Singewald, Matthew J. Lawless, Joel Caporoso, Nicole Brandon, Jonathan A. Coleman, Sunil Saxena, Erik Lindahl, Yan Xu, Pei Tang   +12 more
doaj   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Lateral Habenula contribution in Nicotine addiction : focus on Dopamine, GABA and Serotonin Interactions [PDF]

, 2011
Compelling evidence has shown a pivotal role of dopaminergic function in drug addiction. Recently, the Habenula (Hb) has attracted a great deal of attention as another target for nicotine in the brain because of its role in regulating dopamine (DA ...
Benigno, Arcangelo, Di Giovanni, Giuseppe, Muscat, Richard, Pierucci, Massimo, Pitruzzella, Alessandro, Valentino, Mario, Zammit, Christian   +6 more
core   +1 more source

Elevated Hippocampal Cholinergic Neurostimulating Peptide precursor protein (HCNP-pp) mRNA in the amygdala in major depression [PDF]

, 2015
The amygdala is innervated by the cholinergic system and is involved in major depressive disorder (MDD). Evidence suggests a hyper-activate cholinergic system in MDD.
Argibay, Pablo, Bassi, Sabrina Cecilia, Seney, Marianne L., Sibille, Etienne   +3 more
core   +1 more source

Nicotinic Acetylcholine Receptor α7 Subunit Mediates Migration of Vascular Smooth Muscle Cells Toward Nicotine

Journal of Pharmacological Sciences, 2004
GbaSM-4 cells, vascular smooth muscle cells (VSMCs) derived from brain basilar arteries, were shown to migrate toward d-nicotine by augmenting the actin cytoskeleton in their cell bodies and lamellipodia, and expression of nicotinic acetylcholine ...
Sheng Li, Tiejun Zhao, Hong Xin, Li-Hong Ye, Xiaodong Zhang, Hideyuki Tanaka, Akio Nakamura, Kazuhiro Kohama   +7 more
doaj   +1 more source

Evolving resistance patterns in Tetranychus urticae and Bemisia tabaci in Greece

Pest Management Science, EarlyView.
Greek populations of T. urticae and B. tabaci exhibit evolving multi‐resistance, confirmed by bioassays and molecular markers, highlighting the urgent need for evidence‐based resistance monitoring in IPM. Abstract BACKGROUND Pesticide resistance in agricultural pests remains a major barrier to effective and sustainable crop protection.
Anastasia Kampouraki, Aris Ilias, Kiriaki‐Maria Papapostolou, Styliani Malliaraki, Ioannis Pirgianakis, Evangelia Karakosta, John Vontas, Anastasia Tsagkarakou, Konstantinos Mavridis   +8 more
wiley   +1 more source

Dysregulated homeostasis of acetylcholine levels in immune cells of RR-multiple sclerosis patients [PDF]

, 2016
Multiple sclerosis (MS) is characterized by pro-inflammatory cytokine production. Acetylcholine (ACh) contributes to the modulation of central and peripheral inflammation.
Biagioni, Stefano, Costantini, Erica, DI BARI, Maria, Di Nicola, Marta, D’Angelo, Chiara, Galizia, Sabrina, Gasperini, Claudio, Orlando, Viviana, Porfilio, Italo, Reale, Marcella, Ruggieri, Serena, Tata, Ada Maria   +11 more
core   +2 more sources

Effects of bioinsecticide exposure route on aphids and their natural enemies in oilseed rape

Pest Management Science, EarlyView.
Fatty acids, silicone polymers and surfactants reduced aphid numbers but caused natural enemy mortality under direct exposure, while minimal residual activity suggests potential for targeted, compatible use in integrated pest management. Abstract BACKGROUND Myzus persicae Sulzer and Brevicoryne brassicae L.
Aimee J. Tonks, Tom W. Pope, Simon Cooper, Joe M. Roberts   +3 more
wiley   +1 more source