Results 121 to 130 of about 145,182 (364)

Abnormal response to chronic social defeat stress and fear extinction in a mouse model of Lynx2-based cholinergic dysregulation

Frontiers in Neuroscience
Nicotinic receptor signaling is influential in modulating appropriate responses to salient stimuli within a complex environment. The cholinergic neurotransmitter system drives attention to salient stimuli such as stressors, and aids in orchestrating the ...
Kristin R. Anderson, Peter J. Rogu, Talulla B. Palumbo, Julie M. Miwa   +3 more
doaj   +1 more source

Vagus Nerve Stimulation in Movement Disorders, from Principles to a Systematic Review of Evidence

Movement Disorders, EarlyView.
Abstract Background The vagus nerve (VN), the principal component of the parasympathetic branch of the autonomic nervous system (ANS), mediates bidirec communication between the central nervous system (CNS) and peripheral organs. Vagus nerve stimulation (VNS), delivered through invasive (iVNS) or non‐invasive (transcutaneous cervical [tcVNS] and ...
Francesca Proietti, Matteo Maria Ottaviani, Elisabetta Burchi, Giorgio Vivacqua, Gaia Anzini, Riccardo Antonio Ricciuti, Fioravante Capone, Vaughan G. Macefield, Vincenzo Di Lazzaro, Massimo Marano   +9 more
wiley   +1 more source

Mutation of a nicotinic acetylcholine receptor β subunit is associated with resistance to neonicotinoid insecticides in the aphid Myzus persicae

BMC Neuroscience, 2011
BackgroundMyzus persicae is a globally important aphid pest with a history of developing resistance to insecticides. Unusually, neonicotinoids have remained highly effective as control agents despite nearly two decades of steadily increasing use. In this
C. Bass, A. Puinean, M. Andrews, Penny Cutler, Miriam Daniels, J. Eliaš, V. Paul, Andrew J. Crossthwaite, I. Denholm, L. Field, S. Foster, R. Lind, M. Williamson, R. Slater   +13 more
semanticscholar   +1 more source

Neuronal Reshaping of the Tumor Microenvironment in Tumorigenesis and Metastasis: Bench to Clinic

Medicine Advances, EarlyView.
This graphical abstract illustrates the multidimensional crosstalk between neurons and tumor microenvironment as well as targeted intervention strategies identified in the study. It highlights three core interaction axes: nerve‐tumor crosstalk mediated by neurotransmitters and neurotrophic factors, neuro‐vascular communication driving angiogenesis via ...
Yimao Wu, Ruowei Sun, Shuai Ren, Gokhan Zengin, Mengyao Li   +4 more
wiley   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Nicotinic potentiation of frog retinotectal transmission in tectum layer F by α3β2, α4β2, α2β4, α6β2, or α7 acetylcholine receptor subtypes

Medicina, 2015
Objective: The aim of the study was to explore the effect of semi-specific antagonists and agonists of the nicotinic acetylcholine receptors on the paired-pulse facilitation and nicotinic tonic and phasic potentiation of the frog retinotectal synaptic ...
Armuntas Baginskas, Vilija Kuraitė, Antanas Kuras   +2 more
doaj   +1 more source

Exploring the Impact of Polystyrene Microplastic Beads on Male Gonads of the Marine Mussel, Mytilus galloprovincialis

Environmental Toxicology, EarlyView.
ABSTRACT Plastic, with its remarkable versatility and numerous applications, has greatly benefited humanity. However, its extreme resistance to natural degradation means it persists in the environment for long periods, causing global environmental problems.
Teresa Chianese, Mariachiara Galati, Tiziana Cappello, Maria Maisano, Gennaro Lettieri, Carmela Marinaro, Marina Piscopo, Gianluca Fasciolo, Carlos Gravato, Gaetana Napolitano, Giulia Paolella, Annamaria Locascio, Rosaria Scudiero, Luigi Rosati   +13 more
wiley   +1 more source

Uniquely human CHRFAM7A gene increases the hematopoietic stem cell reservoir in mice and amplifies their inflammatory response. [PDF]

, 2019
A subset of genes in the human genome are uniquely human and not found in other species. One example is CHRFAM7A, a dominant-negative inhibitor of the antiinflammatory α7 nicotinic acetylcholine receptor (α7nAChR/CHRNA7) that is also a neurotransmitter ...
Baird, Andrew, Chan, Theresa W, Cohen, Olga, Costantini, Todd W, Eliceiri, Brian P, Langness, Simone, Treadwell, Sabrina, Williams, Elliot   +7 more
core  

Toxicity of Four Common Environmental Chemicals Across Caenorhabditis elegans Life Stages Supporting the One Health Concept

Environmental Toxicology, EarlyView.
ABSTRACT Pesticides and pharmaceuticals are among the most common chemical groups in waterbodies and soils, and their universal distribution raises concerns about potential adverse effects on nontarget organisms and humans. Reproductive output disruption is of particular concern, as it transposes effects from the individual to the next generations at ...
Fábio Campos, Maria D. Pavlaki, Amadeu M. V. M. Soares, Susana Loureiro   +3 more
wiley   +1 more source

Basic and Clinical Aspects of Non-neuronal Acetylcholine: Overview of Non-neuronal Cholinergic Systems and Their Biological

Journal of Pharmacological Sciences, 2008
Acetylcholine (ACh) is a phylogenetically ancient molecule involved in cell-to-cell signaling in almost all life-forms on earth. Cholinergic components, including ACh, choline acetyltransferase, acetylcholinesterase, and muscarinic and nicotinic ACh ...
Significance Koichiro Kawashima, Takeshi Fujii   +1 more
doaj   +1 more source