Results 91 to 100 of about 42,486 (297)

Opening a hydrophobic gate: the nicotinic acetylcholine receptor as an example [PDF]

arXiv, 2009
To what extent must a hydrophobic gate expand for the channel to count as open? We address this question using the nicotinic acetylcholine receptor (nAChR) as the exemplar. The nAChR is an integral membrane protein which forms a cation selective channel gated by neurotransmitter binding to its extracellular domain.
arxiv  

On the excitation of action potentials by protons and its potential implications for cholinergic transmission [PDF]

, 2014
One of the most conserved mechanisms for transmission of a nerve pulse across a synapse relies on acetylcholine. Ever since the Nobel-prize winning works of Dale and Loewi, it has been assumed that acetylcholine - subsequent to its action on a postsynaptic cell - is split into inactive by-products by acetylcholinesterase.
arxiv   +1 more source

Evaluation of GS‐omega/kappa‐Hxtx‐Hv1a and Bt toxins against Bt‐resistant and ‐susceptible strains of Helicoverpa zea (Boddie) and Spodoptera frugiperda (J.E. Smith)

Pest Management Science, EarlyView.
The addition of 10 μg cm−2 of Cry1Ac to the surface of GS‐omega/kappa‐Hxtx‐Hv1a (ω/κ‐Hv1a) incorporated diet can significantly increase the mortality of Cry‐resistant Helicoverpa zea compared to diets without the Cry1Ac toxin. Abstract BACKGROUND Helicoverpa zea and Spodoptera frugiperda are destructive insect pests of cotton and corn.
Simeon Ross, Fei Yang, José C. Santiago‐González, Heba Abdelgaffar, Dawson D. Kerns, Juan Luis Jurat‐Fuentes, Xiaocun Sun, Dayna Collett, David L. Kerns   +8 more
wiley   +1 more source

The surface accessibility of α-bungarotoxin monitored by a novel paramagnetic probe [PDF]

arXiv, 2011
The surface accessibility of {\alpha}-bungarotoxin has been investigated by using Gd2L7, a newly designed paramagnetic NMR probe. Signal attenuations induced by Gd2L7 on {\alpha}-bungarotoxin C{\alpha}H peaks of 1H-13C HSQC spectra have been analyzed and compared with the ones previously obtained in the presence of GdDTPA-BMA. In spite of the different
arxiv  

Silent agonists for α7 nicotinic acetylcholine receptors

Pharmacological Research, 2023
We discuss models for the activation and desensitization of α7 nicotinic acetylcholine receptors (nAChRs) and the effects of efficacious type II positive allosteric modulators (PAMs) that destabilize α7 desensitized states.
Roger L. Papke, Marta Quadri, Alican Gulsevin   +2 more
doaj  

Severe drug-induced repetitive behaviors and striatal overexpression of VAChT in ChAT-ChR2-EYFP BAC transgenic mice

Frontiers in Neural Circuits, 2014
In drug users, drug-related cues alone can induce dopamine release in the dorsal striatum. Instructive cues activate inputs to the striatum from both dopaminergic and cholinergic neurons, which are thought to work together to support motor learning and ...
Jill R Crittenden, Carolyn J Lacey, Tyrone eLee, Hilary A Bowden, Ann M Graybiel   +4 more
doaj   +1 more source

Serum Proteomic and Metabolomic Signatures of High Versus Low Physical Function in Octogenarians

Aging Cell, EarlyView.
Circulating factors are strongly implicated in modulating biological aging. In this study we show that the serum proteomic and metabolomic profile of high functioning octogenarians suggests lower activation of SASP, preservation of the tryptophan‐kynurenic pathway, higher lipophosphatidyl cholines promoting mitochondrial function, and reduced ...
Ceereena Ubaida‐Mohien, Ruin Moaddel, Sally Spendiff, Norah J. MacMillan, Marie‐Eve Filion, Jose A. Morais, Julián Candia, Liam F. Fitzgerald, Tanja Taivassalo, Paul M. Coen, Luigi Ferrucci, Russell T. Hepple   +11 more
wiley   +1 more source

Cholinergic modulation of the medial prefrontal cortex: the role of nicotinic receptors in attention and regulation of neuronal activity

Frontiers in Neural Circuits, 2014
Acetylcholine release in the medial prefrontal cortex is (mPFC) crucial for normal cognitive performance. Despite the fact that many have studied how acetylcholine affects neuronal processing in the mPFC and thereby influences attention behavior, there ...
Bernard eBloem, Rogier Bernard Poorthuis, Huibert Daniel Mansvelder   +2 more
doaj   +1 more source

Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants [PDF]

arXiv, 2017
We present a framework for computing the gating properties of ligand-gated ion channel mutants using the Monod-Wyman-Changeux (MWC) model of allostery. We derive simple analytic formulas for key functional properties such as the leakiness, dynamic range, half-maximal effective concentration, and effective Hill coefficient, and explore the full spectrum
arxiv  

Psychedelic‐assisted treatment for substance use disorder: A narrative systematic review

Addiction, EarlyView.
Abstract Background and aims This is the first systematic review of the extant literature on all major psychedelic‐assisted treatment for alcohol use disorder (AUD), tobacco use disorder (TUD) and other substance use disorders (SUD). We aimed to summarise the evidence for efficacy of psychedelic‐assisted treatment for AUD, TUD, and SUD; to evaluate its
Theodore Piper, Francesca Small, Sam Brown, Michael Kelleher, Luke Mitcheson, James Rucker, Allan H. Young, John Marsden   +7 more
wiley   +1 more source