Results 61 to 70 of about 43,248 (261)

Nicotinic Cholinergic Receptors in VTA Glutamate Neurons Modulate Excitatory Transmission

Cell Reports, 2018
Summary: Ventral tegmental area (VTA) glutamate neurons are important components of reward circuitry, but whether they are subject to cholinergic modulation is unknown.
Yijin Yan, Can Peng, Matthew C. Arvin, Xiao-Tao Jin, Veronica J. Kim, Matthew D. Ramsey, Yong Wang, Sambashiva Banala, David L. Wokosin, J. Michael McIntosh, Luke D. Lavis, Ryan M. Drenan   +11 more
doaj   +1 more source

Structure and gating mechanism of the α7 nicotinic acetylcholine receptor [PDF]

, 2021
Colleen Noviello, Anant Gharpure, Nuriya Mukhtasimova, Rico Cabuco, Leah Baxter, Dominika Borek, Steven M. Sine, Ryan Hibbs   +7 more
openalex   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Evolving resistance patterns in Tetranychus urticae and Bemisia tabaci in Greece

Pest Management Science, EarlyView.
Greek populations of T. urticae and B. tabaci exhibit evolving multi‐resistance, confirmed by bioassays and molecular markers, highlighting the urgent need for evidence‐based resistance monitoring in IPM. Abstract BACKGROUND Pesticide resistance in agricultural pests remains a major barrier to effective and sustainable crop protection.
Anastasia Kampouraki, Aris Ilias, Kiriaki‐Maria Papapostolou, Styliani Malliaraki, Ioannis Pirgianakis, Evangelia Karakosta, John Vontas, Anastasia Tsagkarakou, Konstantinos Mavridis   +8 more
wiley   +1 more source

Conotoxins Targeting Nicotinic Acetylcholine Receptors: An Overview

Marine Drugs, 2014
Marine snails of the genus Conus are a large family of predatory gastropods with an unparalleled molecular diversity of pharmacologically active compounds in their venom.
Eline K. M. Lebbe, Steve Peigneur, Isuru Wijesekara, Jan Tytgat   +3 more
doaj   +1 more source

Effects of bioinsecticide exposure route on aphids and their natural enemies in oilseed rape

Pest Management Science, EarlyView.
Fatty acids, silicone polymers and surfactants reduced aphid numbers but caused natural enemy mortality under direct exposure, while minimal residual activity suggests potential for targeted, compatible use in integrated pest management. Abstract BACKGROUND Myzus persicae Sulzer and Brevicoryne brassicae L.
Aimee J. Tonks, Tom W. Pope, Simon Cooper, Joe M. Roberts   +3 more
wiley   +1 more source

Mechanisms of Chronic Nicotine Treatment–Induced Enhancement of the Sensitivity of Cortical Neurons to the Neuroprotective Effect of Donepezil in Cortical Neurons

Journal of Pharmacological Sciences, 2010
We have previously shown that chronic donepezil treatment induces nicotinic acetylcholine receptor up-regulation and enhances the sensitivity of the neurons to the neuroprotective effect of donepezil. Further analyses revealed that the nicotinic receptor
Yuki Takada-Takatori, Toshiaki Kume, Yasuhiko Izumi, Tetsuhiro Niidome, Takeshi Fujii, Hachiro Sugimoto, Akinori Akaike   +6 more
doaj   +1 more source

Exploring the Impact of Polystyrene Microplastic Beads on Male Gonads of the Marine Mussel, Mytilus galloprovincialis

Environmental Toxicology, EarlyView.
ABSTRACT Plastic, with its remarkable versatility and numerous applications, has greatly benefited humanity. However, its extreme resistance to natural degradation means it persists in the environment for long periods, causing global environmental problems.
Teresa Chianese, Mariachiara Galati, Tiziana Cappello, Maria Maisano, Gennaro Lettieri, Carmela Marinaro, Marina Piscopo, Gianluca Fasciolo, Carlos Gravato, Gaetana Napolitano, Giulia Paolella, Annamaria Locascio, Rosaria Scudiero, Luigi Rosati   +13 more
wiley   +1 more source

Basic and Clinical Aspects of Non-neuronal Acetylcholine: Expression of Non-neuronal Acetylcholine in Lung Cancer Provides a New Target for Cancer

Journal of Pharmacological Sciences, 2008
Lung cancer is the leading cause of cancer death worldwide and new treatment strategies are clearly needed. The recent discovery that lung and other cancers synthesize and secrete acetylcholine (ACh) which acts as an autocrine growth factor suggests that
Therapy Pingfang Song, Eliot R. Spindel
doaj   +1 more source

Toxicity of Four Common Environmental Chemicals Across Caenorhabditis elegans Life Stages Supporting the One Health Concept

Environmental Toxicology, EarlyView.
ABSTRACT Pesticides and pharmaceuticals are among the most common chemical groups in waterbodies and soils, and their universal distribution raises concerns about potential adverse effects on nontarget organisms and humans. Reproductive output disruption is of particular concern, as it transposes effects from the individual to the next generations at ...
Fábio Campos, Maria D. Pavlaki, Amadeu M. V. M. Soares, Susana Loureiro   +3 more
wiley   +1 more source