Results 61 to 70 of about 42,486 (297)
Synaptic transmission as a cooperative phenomenon in confined systems [PDF]
Condens. Matter Phys., 2017, vol. 20, No. 1, 13804, 2017 In this review paper, the theory of synaptic transmission (ST) was developed and discussed. We used the hypothesis of isomorphism between: (a) the cooperative behavior of mediators --- acetylcholine molecules (ACh) and cholinoreceptors in a synaptic cleft with binding into mediator-receptor (AChR) complexes, (b) the critical phenomena in confined ...
arxiv +1 more source
Chemical Proteomics Reveals Human Off‐Targets of Fluoroquinolone Induced Mitochondrial Toxicity
Angewandte Chemie International Edition, EarlyView.A schematic overview of the adverse effects of Ciprofloxacin related to mitochondrial toxicity. AIFM1 plays a role in the MIA40‐mediated import into the IMS and oxidative folding of nuclear‐encoded proteins, including ETC complexes I and IV subunits. Ciprofloxacin disrupts the IMS import machinery, impairing ETC function.
Till Reinhardt +14 more
wiley +1 more source
Origin of acetylcholine antagonism in ELIC, a bacterial pentameric ligand-gated ion channel
Communications Biology, 2022 A structural and functional study of the prokaryotic ligand-gated ion channel, ELIC, provides insight into the origin of agonism and antagonism at nicotinic acetylcholine receptors.
Mykhaylo Slobodyanyuk +6 more
doaj +1 more source
Neural Regeneration Research, 2016 Myasthenia gravis is an autoimmune disorder in which antibodies have been shown to form against the nicotinic acetylcholine nicotinic postsynaptic receptors located at the neuromuscular junction.
Hai-peng Huang, Hong Pan, Hong-feng Wang
doaj +1 more source
Deciphering the skeletal interoceptive circuitry to control bone homeostasis
BMEMat, EarlyView.This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu +7 more
wiley +1 more source
Autoimmunity to neuronal nicotinic acetylcholine receptors
Pharmacological Research, 2023 Nicotinic acetylcholine receptors (nAChRs) are widely expressed in many and diverse cell types, participating in various functions of cells, tissues and systems.
Maria Pechlivanidou +10 more
doaj
Cholinergic switch between two types of slow waves in cerebral cortex [PDF]
Cerebral Cortex 2019, 2018 Sleep slow waves are known to participate in memory consolidation, yet slow waves occurring under anesthesia present no positive effects on memory. Here, we shed light onto this paradox, based on a combination of extracellular recordings in vivo, in vitro, and computational models.
arxiv +1 more source
Chronic Diseases and Translational Medicine, EarlyView.Donanemab, approved by the U.S. FDA in July 2024, targets amyloid plaques in the brain to treat Alzheimer's disease in patients with mild cognitive impairment or mild dementia. ABSTRACT Substantial research has been conducted to identify an efficient treatment for Alzheimer's disease (AD).
Nandhini Jayaprakash +1 more
wiley +1 more source
The Role of Nicotinic Receptors on Ca2+ Signaling in Bovine Chromaffin Cells
Current Issues in Molecular BiologyChromaffin cells have been used as a physiological model to understand neurosecretion in mammals for many years. Nicotinic receptors located in the cells’ membrane are stimulated by acetylcholine, and they participate in the exocytosis of chromaffin ...
Amparo Gil +3 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2015 Prefrontal layer 6 (L6) pyramidal neurons play an important role in the adult control of attention, facilitated by their strong activation by nicotinic acetylcholine receptors.
Lily eKang +6 more
doaj +1 more source