Nrt1 and Tna1-independent export of NAD+ precursor vitamins promotes NAD+ homeostasis and allows engineering of vitamin production. [PDF]
PLoS ONE, 2011 NAD(+) is both a co-enzyme for hydride transfer enzymes and a substrate of sirtuins and other NAD(+) consuming enzymes. NAD(+) biosynthesis is required for two different regimens that extend lifespan in yeast.
Peter Belenky +4 more
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Lack of nicotinic acid effect on cholesterol metabolism of the rat*
Journal of Lipid Research, 1960 The effect of the addition of 1 per cent nicotinic acid to the diet of the rat on serum, liver, and carcass cholesterol, and on the incorporation of acetate-1-C14 into cholesterol by the intact animal were studied.
Charles H. Duncan, Maurice M. Best
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It takes two to tango: NAD+ and sirtuins in aging/longevity control [PDF]
, 2016 The coupling of nicotinamide adenine dinucleotide (NAD+) breakdown and protein deacylation is a unique feature of the family of proteins called ‘sirtuins.’ This intimate connection between NAD+ and sirtuins has an ancient origin and provides a ...
Guarente, Leonard, Imai, Shin-ichiro
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Oxidation of cholesterol-26-C14 by rat liver mitochondria: effect of nicotinic acid*
Journal of Lipid Research, 1960 The effect of nicotinic acid upon the oxidation of the terminal carbon atoms of cholesterol-26-C14 by rat liver mitochondrial preparations has been studied.
David Kritchevsky +2 more
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The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders [PDF]
, 2013 Understanding the neurochemical basis for cognitive function is one of the major goals of neuroscience, with a potential impact on the diagnosis, prevention and treatment of a range of psychiatric and neurological disorders.
Akagbosu +172 more
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Journal of Animal Reproduction and Biotechnology, 2015 The objective of this study was to investigate the efficiency of nicotinic acid on sperm cryosurvival and fertilization ability in frozen-thawed boar semen. Boar semen was collected by glove-hand method and was frozen using freezing solution treated to 0,
Yu-Jin Kim +7 more
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Scientific Opinion on the safety and efficacy of niacin (nicotinic acid and nicotinamide) as a feed additive for all animal species based on a dossier submitted by Vertellus Specialties Belgium BV [PDF]
EFSA Journal, 2012 <p>The term ‘niacin’ is used as a generic description of nicotinic acid and nicotinamide with pyridine as the basic structure. Nicotinic acid and nicotinamide function mainly as precursors of the co-enzymes NAD and NADP.
EFSA Panel on Additives and Products or Substances used in Animal Feed
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The influence of exogenous growth regulators on the cannabinoid content and the main selection traits of hemp (Cannabis sativa L. ssp. Sativa) [PDF]
Journal of Agricultural Sciences (Belgrade), 2022 Hemp (Cannabis sativa L.) is a species sensitive to the influence of exogenous growth regulators, both in the treatment of vegetative plant tissues and in vitro culture. 1-naphthylacetic acid, indole-3-acetic acid, 2,4-dichlorophenoxyacetic acid, kinetin,
Mishchenko Serhii V. +5 more
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An expanding range of targets for kynurenine metabolites of tryptophan [PDF]
, 2013 The kynurenine pathway of tryptophan metabolism accounts for most of the tryptophan that is not committed to protein synthesis and includes compounds active in the nervous and immune systems.
Darlington, L. Gail +2 more
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Cloning and characterization of the hamster and guinea pig nicotinic acid receptors
Journal of Lipid Research, 2007 In this study, we present the identification and characterization of hamster and guinea pig nicotinic acid receptors. The hamster receptor shares ∼80–90% identity with the nucleotide and amino acid sequences of human, mouse, and rat receptors. The guinea
April Smith Torhan +3 more
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