Results 71 to 80 of about 55,760 (248)

On the Generation of Bioactive Trigonelline Degradation Products upon Coffee Roasting and their Bioappearance after Coffee Consumption

Czech Journal of Food Sciences, 2009
Besides caffeine, the betaine N-methyl nicotinic acid, also known as trigonelline, is commonly reported as the second most abundant alkaloid in raw coffee beans.
R. Lang, T. Hofmann
doaj   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

Pyridine nucleotide synthesis by rat adipose tissue in vitro

Journal of Lipid Research, 1967
The synthesis of NAD and NADP by rat adipose tissue was measured in vitro. Nicotinamide-7-14C and NaH232PO4 were incorporated together into NAD with a 32P/14C ratio of 1.82 and nicotinic-7-14C acid and NaH232PO4 with a ratio of 1.94.
Richard W. Hanson, Zigmund Z. Ziporin
doaj   +1 more source

Micro‐QuEChERS Extraction for Broad‐Spectrum LC‐QQQ‐MS Quantification of Nitazene Analogs in Plasma: A Validated Method With Casework Application

Drug Testing and Analysis, EarlyView.
Micro‐QuEChERS sample preparation coupled to LC‐QQQ‐MS enabled sensitive quantification of nitazene analogs in 100 μL of plasma. The validated method provided low detection limits and was successfully applied to an authentic intoxication case involving N‐pyrrolidino protonitazene, supporting clinical and forensic toxicology workflows.
Karla A. O. Souza, Náthaly C. B. F. Santos, Rafael Lanaro, Sara E. Walton, Alex J. Krotulski, Barry K. Logan, Mauricio Yonamine, Jose Luiz Costa   +7 more
wiley   +1 more source

Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle

Developmental Dynamics, EarlyView.
Abstract Background Actin filament organization in cardiomyocytes critically depends on the formin Fhod3, but a role for Fhod3 in skeletal muscle development has not yet been described. Results We demonstrate here that in zebrafish mutated for one of two fhod3 paralog genes, fhod3a, skeletal muscle of the trunk appears normal through 2 days post ...
Aubrie Russell, Tracy Eng, Jeffrey D. Amack, David Pruyne   +3 more
wiley   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Effect of nicotinic acid on the survival rate, and neurodegeneration of transgenic Drosophila melanogasterwith overexpression of human APP gene

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2013
Transgenic Drosophila melanogaster lines modeling the main neuromorphological markers of Alzheimer's disease were used to study the neuroprotective properties of nicotinic acid.
O. I. Bolshakova, D. I. Rodin, S. I. Timoshenko, E. M. Latypova, S. V. Sarantseva   +4 more
doaj  

Synthesis and Anti-Inflammatory Activity of New Nicotinoyl Amides

Eurasian Chemico-Technological Journal
The article presents the results of a study of the amination reaction of nicotinic acid chlorohydride with amines morpholine, cytisine, and 1-aminoadamantane, which are often used in the search and creation of drugs for respiratory and circulatory ...
O.A. Nurkenov, S.D. Fazylov, Zh.S. Nurmaganbetov, T.M. Seilkhanov, A.Zh. Mendibayeva, S.K. Kabieva, E.M. Satbaeva   +6 more
doaj   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Cytotoxicity of 19 Pesticides in Rainbow Trout Gill, Liver, and Intestinal Cell Lines

Environmental Toxicology and Chemistry, EarlyView.
Abstract The rainbow trout gill cell line (RTgill‐W1), via test guideline 249 of the Organisation for Economic Co‐operation and Development, has been established as a promising New Approach Methodology, although to advance confidence in the method more case studies are needed that: 1) expand our understanding of applicability domains (chemicals with ...
Sophie Emberley‐Korkmaz, Krittika Mittal, Na'im Temlock, Jessica Head, Niladri Basu   +4 more
wiley   +1 more source