Results 191 to 200 of about 34,315 (270)

Novel Drug Targets for Neurodegenerative Diseases of Elderly People to Develop Effective Therapeutics: A Comprehensive Analysis. [PDF]

Adv Pharmacol Pharm Sci
Biswas P, Rahman MH, Tabassum A, Shoyshob TZ, Jalouli M, Islam Tareq MM, Imtiaz M, Dona HA, Harrath AH, Rahman MA.   +9 more
europepmc   +1 more source

Association Between Levels of the Acute Phase Proteins Alpha‐1‐Acid Glycoprotein and C‐Reactive Protein and Serum Concentrations of Clozapine: A Study of 1106 Therapeutic Drug Monitoring Samples

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.
ABSTRACT Several publications have reported elevated clozapine concentrations in patients experiencing infections or inflammatory reactions. Proposed mechanisms include increased levels of pro‐inflammatory cytokines that may inhibit clozapine metabolism and enhanced binding of clozapine to the acute phase protein alpha‐1‐acid glycoprotein (AGP).
Ketil Arne Espnes, Olav Spigset, Guro Emilie Bratt, Marit Tilrem, Sarita Hamnes, Eirik Skogvoll, Ragnhild Bergene Skråstad   +6 more
wiley   +1 more source

Mechanisms and Applications of Gastrointestinal Microbiota-Metabolite Interactions in Ruminants: A Review. [PDF]

Microorganisms
Urga, Wang X, Wei H, Zhao G.
europepmc   +1 more source

Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder

Journal of Internal Medicine, Volume 299, Issue 3, Page 302-327, March 2026.
Abstract Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti‐seizure treatments, nearly 30%–40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and
Marco Ledri, Merab Kokaia
wiley   +1 more source

Protease enzyme in broiler diets on the nutritional quality of soybean meals from different origins. [PDF]

Trop Anim Health Prod
da Silva DL, Dalólio FS, Valentim JK, de Léo RAR, de Oliveira HF, do Vale Teixeira L, Reis TL, Fascina VB, Calderano AA.   +8 more
europepmc   +1 more source

Timing of NAD Deficiency During Organogenesis Dictates Defect Type and Penetrance

The FASEB Journal, Volume 40, Issue 3, 15 February 2026.
Pregnant mice on a vitamin B3‐free and tryptophan‐limited diet have embryos with Congenital NAD Deficiency Disorder, characterized by malformations and/or death. We longitudinally tracked the maternal NAD metabolome, embryo growth, and malformation occurrence. Mice with lower NAD Salvage Pathway metabolite levels and minimal levels of derived excretion
Kayleigh Bozon, Hartmut Cuny, Nana Sunn, Ella M. M. A. Martin, Delicia Z. Sheng, Gavin Chapman, Sally L. Dunwoodie   +6 more
wiley   +1 more source

Neonatal Pellagra. [PDF]

Clin Case Rep
Kitaoka H, Kakiuchi S.
europepmc   +1 more source

Reply to Behrman: “ N -Formylmaleamic acid: An intermediate in nicotinic acid metabolism”

, 2008
José I. Jiménez, Ángeles Canales, Jesús Jiménez‐Barbero, Krzysztof Ginalski, Leszek Rychlewski, José L. Garcı́a, Eduardo Dı́az   +6 more
openalex   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, Volume 16, Issue 2, Page 412-431, February 2026.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

The differential impact of three different NAD⁺ boosters on circulatory NAD and microbial metabolism in humans. [PDF]

Nat Metab
Christen S, Redeuil K, Goulet L, Giner MP, Breton I, Rota R, Frézal A, Nazari A, Van den Abbeele P, Godin JP, Nutten S, Cuenoud B.   +11 more
europepmc   +1 more source