Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations
FEBS Open Bio, EarlyView.Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro +8 more
wiley +1 more source
Structural correlates of affinity in fetal versus adult endplate nicotinic receptors
Nature Communications, 2016 Adult and fetal nicotinic acetylcholine receptors (AChRs) have different functional requirements and affinity for ACh. Here, the authors use molecular dynamics and electrophysiology to investigate this affinity, and identify four amino acids that when ...
Tapan Kumar Nayak +3 more
doaj +1 more source
Contribution of gut microbiomes and their metabolomes to the performance of Dorper and Tan sheep
Frontiers in Microbiology, 2022 BackgroundLivestock is an excellent source of high nutritional value protein for humans; breeding livestock is focused on improving meat productivity and quality. Dorper sheep is a distinguished breed with an excellent growth performance, while Tan sheep
Yuhao Ma +7 more
doaj +1 more source
Chromium (III) complexes and their relationship to the glucose tolerance factor : a thesis presented in partial fulfillment of the requirements for the degree of Master of Science in Chemistry at Massey University [PDF]
, 1982 Two forms of the dinicotinate complex Cr(nic)2(H2O)3OH were formed which were yellow and blue, respectively. For the yellow form the nicotinic acid ligands were coordinated via the pyridine ring nitrogen atom but this complex was biologically inactive ...
Cooper, Juan Anton
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FEBS Open Bio, EarlyView.Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel +9 more
wiley +1 more source
Advanced Functional Materials, EarlyView.MAMAWEL is introduced as the first calibration‐free potentiometric sensor for at‐home mastitis diagnosis. By measuring the sodium‐to‐potassium ratio in breast milk, the device reliably differentiates between healthy and mastitis‐affected samples with less than 10% error.
Ali Soleimani +9 more
wiley +1 more source
NACHO Engages N-Glycosylation ER Chaperone Pathways for α7 Nicotinic Receptor Assembly
Cell Reports, 2020 Summary: The α7 nicotinic acetylcholine receptor participates in diverse aspects of brain physiology and disease. Neurons tightly control α7 assembly, which relies upon NACHO, an endoplasmic reticulum (ER)-localized integral membrane protein.
Hae-Jin Kweon +7 more
doaj +1 more source
The effects of solvents and structure on the electronic absorption spectra of the isomeric pyridine carboxylic acid N-oxides [PDF]
Chemical Industry and Chemical Engineering Quarterly, 2013 The ultraviolet absorption spectra of the carboxyl group of three isomeric pyridine carboxylic acids N-oxides (picolinic acid N-oxide, nicotinic acid N-oxide and isonicotinic acid N-oxide) were determined in fourteen solvents in the wavelength range ...
Drmanić Saša Ž. +4 more
doaj +1 more source
Treatment of Hypercholesterolemia with Nicotinic Acid [PDF]
Circulation, 1958 Nicotinic acid was administered orally to 33 patients with hypercholesterolemia in doses varying from 1.5 to 6.0 Gm. per day for periods of 3 months to 1½ years. Significant, sustained, and reproducible decreases in the concentration of cholesterol and total lipids in the plasma and of serum beta-lipoprotein cholesterol were observed in a majority of ...
Nelson W. Barker +3 more
openaire +3 more sources
An examination of the putative glucose tolerance factor activity of amino acid and peptide fractions isolated from brewer's yeast : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Chemistry at Massey University [PDF]
, 1985 The first report of the possible existance of a glucose tolerance factor (GTF) was made by Mertz and Schwarz (1955) who noticed that a dietary additive, termed factor 3, isolated from an enzymatic casein hydrolysate (Schwarz (1952)), maintained normal ...
Jackson, Timothy Graham
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