Neuronal nicotinic receptors as new targets foramphetamine-induced oxidative damage and neurotoxicity [PDF]
, 2011 Amphetamine derivatives such as methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) are drugs widely abused in a recreational context.
Pubill Sánchez, David +7 more
core +1 more source
Chemical Synthesis of a Functional Fluorescent-Tagged α-Bungarotoxin
Toxins, 2022 α-bungarotoxin is a large, 74 amino acid toxin containing five disulphide bridges, initially identified in the venom of Bungarus multicinctus snake. Like most large toxins, chemical synthesis of α-bungarotoxin is challenging, explaining why all previous ...
Oliver Brun +9 more
doaj +1 more source
PLoS ONE, 2019 Bordetella bacteria are respiratory pathogens of humans, birds, and livestock. Bordetella pertussis the causative agent of whopping cough remains a significant health issue.
William T Booth +3 more
doaj +1 more source
Synthesis of 1,4-dihydro-2-methyl-4-oxo-nicotinic acid: Ochiai's route failed
, 2006 The synthesis of 1,4-dihydro-2-methyl- and 1,4-dihydro-1,2-dimethyl-4-oxo-nicotinic acids was accomplished following a route other than Ochiai’s procedure, which yielded the isomer 1,6-dihydro-2-methyl-6-oxo-nicotinic acid ethyl ester, and not the 4-oxo ...
DI MARCO, VALERIO +2 more
core +1 more source
Structural correlates of affinity in fetal versus adult endplate nicotinic receptors
Nature Communications, 2016 Adult and fetal nicotinic acetylcholine receptors (AChRs) have different functional requirements and affinity for ACh. Here, the authors use molecular dynamics and electrophysiology to investigate this affinity, and identify four amino acids that when ...
Tapan Kumar Nayak +3 more
doaj +1 more source
NACHO Engages N-Glycosylation ER Chaperone Pathways for α7 Nicotinic Receptor Assembly
Cell Reports, 2020 Summary: The α7 nicotinic acetylcholine receptor participates in diverse aspects of brain physiology and disease. Neurons tightly control α7 assembly, which relies upon NACHO, an endoplasmic reticulum (ER)-localized integral membrane protein.
Hae-Jin Kweon +7 more
doaj +1 more source
The effects of solvents and structure on the electronic absorption spectra of the isomeric pyridine carboxylic acid N-oxides [PDF]
Chemical Industry and Chemical Engineering Quarterly, 2013 The ultraviolet absorption spectra of the carboxyl group of three isomeric pyridine carboxylic acids N-oxides (picolinic acid N-oxide, nicotinic acid N-oxide and isonicotinic acid N-oxide) were determined in fourteen solvents in the wavelength range ...
Drmanić Saša Ž. +4 more
doaj +1 more source
Contribution of gut microbiomes and their metabolomes to the performance of Dorper and Tan sheep
Frontiers in Microbiology, 2022 BackgroundLivestock is an excellent source of high nutritional value protein for humans; breeding livestock is focused on improving meat productivity and quality. Dorper sheep is a distinguished breed with an excellent growth performance, while Tan sheep
Yuhao Ma +7 more
doaj +1 more source
Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects. [PDF]
, 2015 Activation of nicotinic acetylcholine receptors (nAChRs) is associated with the binding of agonists such as acetylcholine to an extracellular site that is located at the interface between two adjacent receptor subunits.
Dhankher, P +4 more
core
, 2019 A new series of chiral carboxypyridinium dithiophosphates were synthesized by the reactions of nicotinic, isonicotinic, and picolinic acids with dithiophosphoric acid on the basis (1S)-endo-(–)-borneol in benzene or ethanol.
Ramazan Z. Salikhov (7468970) +10 more
core +2 more sources