Results 41 to 50 of about 925,140 (188)

HDL Functions—Current Status and Future Perspectives

Biomolecules, 2023
Cardiovascular disease (CVD) is the leading cause of death in Western countries. A low HDL-C is associated with the development of CVD. However, recent epidemiology studies have shown U-shaped curves between HDL-C and CVD mortality, with paradoxically ...
Yasuhiro Endo, Masanori Fujita, Katsunori Ikewaki   +2 more
doaj   +1 more source

Plant Organic Acids as Natural Inhibitors of Foodborne Pathogens

Applied Sciences
Background: Foodborne infections affect approximately 600 million people annually. Simultaneously, many plants contain substances like organic acids, which have antimicrobial activity. The aim of this study was to examine the effects of 21 organic acids,
Tomasz M. Karpiński, Marcin Ożarowski
doaj   +1 more source

Changes in conformation and subcellular distribution of alpha(4)beta(2) nicotinic acetylcholine receptors revealed by chronic nicotine treatment and expression of subunit chimeras [PDF]

, 2002
Chronic exposure to nicotine, as occurs during tobacco smoking, is one of several factors that have been reported to cause an upregulation of neuronal nicotinic acetylcholine receptors (nAChRs).
Harkness, PC, Millar, NS
core  

Hypertriglyceridemia Induced Pancreatitis (Chylomicronemia Syndrome) Treated with Supportive Care

Case Reports in Critical Care, 2014
Hypertriglyceridemia is a rare cause of pancreatitis. In treatment pancreatic rest, lifestyle changes, medications (fibrates, n-3 polyunsaturated fatty acids, and nicotinic acid) are essential. Many experimental treatment modalities have been reported as
Emin Uysal, Yahya Ayhan Acar, Emel Gökmen, Ahmet Kutur, Hatice Doğan   +4 more
doaj   +1 more source

Pyridine C3-arylation of nicotinic acids accessible via a multicomponent reaction: an entry to all-substituted-3,4-diarylated pyridines

, 2017
An efficient route for the synthesis of penta-substituted/functionalized-3,4-diarylated pyridines, biologically important templates, via pyridine C3-arylation of nicotinic acids has been developed.
HURA, N, SINHA, K, GUCHHAIT, SK, PANDA, D   +3 more
core   +1 more source

AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity [PDF]

, 2007
Neuronal nAChRs are a diverse family of pentameric ion channels with wide distribution throughout cells of the nervous and immune systems. However, the role of specific subtypes in normal and pathological states remains poorly understood due to the lack ...
Sixma, Titia K., Alewood, Paul F., Buettner, Regina, van Elk, R, Smit, A.B., Sixma, T., Dutertre, S., Nicke, A, van Elk, R., Smit, A., Nicke, Annette, Alewood, P. F., Sixma, T.K., Kendel, Y., Smit, AB, Lewis, R. J., Hopping, G., Kendel, Y, Büttner, Regina, Elk, René van, Ulens, C, Ulens, Chris, Buttner, R, Kendel, Yvonne, Sixma, TK, Fish, Alexander, Lewis, R.J., Schroeder, Christina, Lewis, Richard,, Smit, August,, Alewood, P.F., Lewis, Richard J., Fish, A, Sixma, Titia,, Schroeder, C., Alewood, Paul,, Fish, A., Alewood, P., Dutertre, Sébastien, Smit, August B., Ulens, C., Hopping, Gene, Nicke, A., Lewis, R., Ulens, Chris (author), Schroeder, Christina (author), Dutertre, Sébastien (author), Lewis, Richard J. (author), Lewis, Richard, J, Büttner, Regina (author), van Elk, René (author), Alewood, Paul, F, Fish, Alexander (author), Nicke, Annette (author), Sixma, Titia, K, Kendel, Yvonne (author), Hopping, Gene (author), Alewood, Paul F. (author), Sixma, Titia K. (author), Smit, August, B, Smit, August B. (author), Büttner, R., van Elk, Rene   +62 more
core   +1 more source

Autocrine negative feedback regulation of lipolysis through sensing of NEFAs by FFAR4/GPR120 in WAT

Molecular Metabolism, 2020
Objectives: Long-chain fatty acids (LCFAs) released from adipocytes inhibit lipolysis through an unclear mechanism. We hypothesized that the LCFA receptor, FFAR4 (GPR120), which is highly expressed in adipocytes, may be involved in this feedback ...
Anna Sofie Husted, Jeppe H. Ekberg, Emma Tripp, Tinne A.D. Nissen, Stijn Meijnikman, Shannon L. O'Brien, Trond Ulven, Yair Acherman, Sjoerd C. Bruin, Max Nieuwdorp, Zach Gerhart-Hines, Davide Calebiro, Lars O. Dragsted, Thue W. Schwartz   +13 more
doaj   +1 more source

Simple modifications of nicotinic, isonicotinic, and 2,6-dichloroisonicotinic acids toward new weapons against plant diseases

Open Chemistry, 2021
Recently, the biggest challenge in agriculture is the search for new, effective, and ecological methods of protecting plants against diseases. One of the fastest-growing and prospective strategies is a method based on activating the plant’s natural ...
Czerwoniec Patrycja, Szymkowiak Joanna, Smiglak Marcin   +2 more
doaj   +1 more source

Step by step palladium mediated syntheses of new 2-(pyridin-2-yl)-6-R-nicotinic acids and esters

, 2010
Taking advantage of palladium peculiar “rollover” C,N cyclometallation, it is possible to promote C(3) functionalization of 6-alkyl-substituted-2,2′-bipyridines. The carbonylation reaction of rollover species [Pd(Ln)Cl]2, (HL1 = 6-isopropyl-2,2′-bipy, 1;
Stoccoro, Sergio, Cinellu, Maria Agostina, Minghetti, Giovanni, Petretto, Giacomo Luigi, Zucca, Antonio, Minghetti, G., Giacomo Luigi Petretto, Maria Agostina Cinellu, Sergio Stoccoro, Antonio Zucca, Giovanni Minghetti   +10 more
core   +1 more source

Similarity Between the Action of Pteridines and Tryptophan Metabolites on Lipid Metabolism

Pteridines, 1999
Incorporation of fatty acids into phospholipids has been investigated using samples of rat liver tissue homogenate, Krebs-Ringer-phosphate buffer (pH=7.4) containing 0.3% albumin, fatty acid mixture and glycerol. The addition of anthranilic acid (2.2 and
Rudzite Vera, Jurika Edite, Widner Bernhard, Fuchs Dietmar   +3 more
doaj   +1 more source