Results 141 to 150 of about 41,965 (298)

Openings of the rat recombinant alpha1 homomeric glycine receptor as a function of the number of sgonist molecules bound [PDF]

, 2002
The functional properties of rat homomeric {alpha}1 glycine receptors were investigated using whole-cell and outside-out recording from human embryonic kidney cells transfected with rat {alpha}1 subunit cDNA.
Beato, M., Colquhoun, D., Groot-Kormelink, P.J., Sivilotti, L.G.   +3 more
core  

Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale. [PDF]

Geriatr Gerontol Int
ABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Mogi M, Liu S, Suzuki Y, Shibata Y, Yamada S.   +4 more
europepmc   +2 more sources

Pharmacological MRI: Utility in Understanding Drug Mechanisms in Psychiatric Disorders

Journal of Magnetic Resonance Imaging, Volume 63, Issue 2, Page 346-363, February 2026.
ABSTRACT Pharmacological MRI (pharmaMRI) has emerged as a powerful tool to study how psychoactive drugs affect brain function and to uncover mechanisms of drug action in psychiatric disorders. This review provides an overview of key techniques used in pharmaMRI, including BOLD‐fMRI, arterial spin labeling (ASL), and cerebral blood volume (CBV) mapping,
Christin Y. Sander, Tudor M. Ionescu, Mitul A. Mehta, Ottavia Dipasquale, Anouk Schrantee   +4 more
wiley   +1 more source

Insights into channel function via channel dysfunction [PDF]

, 2003
The nicotinic synapse has been a touchstone for advances in neuroscience ever since Jean Nicot, the French ambassador to Portugal, sent some tobacco seeds home to Paris in 1550 with a note that the New World plant had interesting effects when smoked. Now
Leite, John F., Lester, Henry A., Rodrigues-Pinguet, Nivalda   +2 more
core  

Preclinical Characterization of A‐582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition‐Enhancing Properties [PDF]

, 2008
Karin Tietje, David J. Anderson, Robert S. Bitner, Eric A.G. Blomme, Paul J. Brackemeyer, Clark A. Briggs, Kaitlin E. Browman, Dagmar Bury, Peter Curzon, Karla Drescher, Jennifer M. Frost, Ryan M. Fryer, Gerard B. Fox, Jens Halvard Grønlien, Monika Håkerud, Earl J. Gubbins, Sabine Halm, Richard Harris, Rosalind Helfrich, Kathy L. Kohlhaas, Devalina Law, John Malysz, Kennan C. Marsh, Ruth L. Martin, Michael D. Meyer, Angela L. Molesky, Arthur L. Nikkel, Stephani Otte, Liping Pan, Pamela S. Puttfarcken, Richard J. Radek, Holly M. Robb, Eva Spies, Kirsten Thorin‐Hagene, Jeffrey F. Waring, Hilde Ween, Hongyu Xu, Murali Gopalakrishnan, William H. Bunnelle   +38 more
openalex   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Varenicline in the treatment of tobacco dependence

Neuropsychiatric Disease and Treatment, 2008
Karl Fagerström1, John Hughes21Smokers Information Centre, Fagerström Consulting AB, Berga Alle 1, 25452 Helsingborg, Sweden; 2University of Vermont, Burlington, Vermont, USAAbstract: Varenicline, a partial agonist of α4& ...
Karl Fagerström, John Hughes
doaj  

Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies

MedComm, Volume 7, Issue 2, February 2026.
The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreting nerve growth factors; (2) nerve‐derived bioactive molecules can induce perineural invasion of tumor and regulate the malignant phenotype of tumor, such ...
Yan Fu, Zhi‐Shan Ge, Qing‐Yue Cao, Zi‐Han Li, An Zhang, Hai‐Dong Zhu, Gao‐Jun Teng   +6 more
wiley   +1 more source

Mapping the Agonist Binding Site of the Nicotinic Acetylcholine Receptor [PDF]

, 2000
Deirdre Sullivan, Jonathan B. Cohen
openalex   +1 more source

Dihydrotestosterone and Finasteride Effects on Alcohol Cue‐Elicited Brain Activity in Males With Heavy Episodic Drinking

Addiction Biology, Volume 31, Issue 2, February 2026.
In a randomized, double‐blind, placebo‐controlled crossover study, we investigated whether finasteride‐induced reduction of dihydrotestosterone alters alcohol cue‐elicited brain activity and craving in males with heavy episodic drinking. Although dihydrotestosterone concentrations were not associated with neural cue reactivity, finasteride increased ...
Rafat Boroumand‐Jazi, Sabine Hoffmann, Iris Reinhard, Patrick Bach, Wolfgang H. Sommer, Marlene Kundlacz, Christian P. Müller, Matthias Reichl, Haoye Tan, Leonard P. Wenger, Anne Beck, Sabine Vollstädt‐Klein, Falk Kiefer, Christiane Mühle, Sarah Gerhardt, Bernd Lenz   +15 more
wiley   +1 more source