Structural mechanism of muscle nicotinic receptor desensitization and block by curare
Nature Structural & Molecular Biology, 2022 Md Mahfuzur Rahman +6 more
semanticscholar +1 more source
Successful Cessation Programs that Reduce Comorbidity May Explain Surprisingly Low Smoking Rates Among Hospitalized COVID-19 Patients [PDF]
, 2020 A recent, non-peer-reviewed meta-analysis suggests that smoking may reduce the risk of hospitalization with COVID-19 because the prevalence of smoking among hospitalized COVID-19 is less than that of the general population.
Alvarez, R. Michael +7 more
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Diabetes, Obesity and Metabolism, EarlyView.Abstract Aims To evaluate whether initiating sodium‐glucose cotransporter 2 inhibitors (SGLT2i) within 3 months after a urinary tract infection (UTI) is associated with improved long‐term outcomes in patients with type 2 diabetes mellitus (T2DM), compared with dipeptidyl peptidase‐4 inhibitors (DPP‐4i).
Hsiao‐Wei Wang +5 more
wiley +1 more source
Uniquely human CHRFAM7A gene increases the hematopoietic stem cell reservoir in mice and amplifies their inflammatory response. [PDF]
, 2019 A subset of genes in the human genome are uniquely human and not found in other species. One example is CHRFAM7A, a dominant-negative inhibitor of the antiinflammatory α7 nicotinic acetylcholine receptor (α7nAChR/CHRNA7) that is also a neurotransmitter ...
Baird, Andrew +7 more
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d‐amino acids: new functional insights
The FEBS Journal, EarlyView.This review explores recent advances in understanding d‐amino acids (d‐AAs) and their pivotal roles across organisms, from plants to humans. d‐AAs have been implicated in key physiological processes, including cancer, inflammation, immune regulation, kidney disease, diabetes, and nervous system function.
Loredano Pollegioni +5 more
wiley +1 more source
Varenicline in the treatment of tobacco dependence
Neuropsychiatric Disease and Treatment, 2008 Karl Fagerström1, John Hughes21Smokers Information Centre, Fagerström Consulting AB, Berga Alle 1, 25452 Helsingborg, Sweden; 2University of Vermont, Burlington, Vermont, USAAbstract: Varenicline, a partial agonist of α4& ...
Karl Fagerström, John Hughes
doaj
Chemical modification of epibatidine causes a switch from agonist to antagonist and modifies its selectivity for neuronal nicotinic acetylcholine receptors [PDF]
, 2000 Jörg E Spang +5 more
openalex +1 more source
Journal of Intellectual Disability Research, EarlyView.ABSTRACT Introduction People with intellectual disability (ID) face increased vulnerability to addictive behaviours, yet effective interventions are under‐researched. This study aimed to systematically review existing interventions for substance use and problem gambling in this population. Methods Following PRISMA guidelines, we searched Web of Science,
Amalia Udeanu +5 more
wiley +1 more source
Preclinical Pharmacology of ABT‐594: A Nicotinic Acetylcholine Receptor Agonist for the Treatment of Pain [PDF]
, 2000 Michael D. Meyer +6 more
openalex +1 more source
Establishing an Ion Pair Interaction in the Homomeric {rho}1 {gamma}-Aminobutyric Acid Type A Receptor That Contributes to the Gating Pathway [PDF]
, 2007 {gamma}-Aminobutyric acid type A (GABAA) receptors are members of the Cys-loop superfamily of ligand-gated ion channels. Upon agonist binding, the receptor undergoes a structural transition from the closed to the open state, but the mechanism of gating ...
Dougherty, Dennis A. +2 more
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