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Selective α7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis [PDF]
, 2010 Susanne A. Snoek +9 more
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ChemInform Abstract: Nicotinic Acid Receptor Agonists [PDF]
ChemInform, 2008 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Graeme Semple +2 more
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Nicotinic Agonists and Psychosis
Current Drug Target -CNS & Neurological Disorders, 2002Schizophrenia patients have insufficient inhibitory processing of identical paired auditory stimuli. This deficient "auditory gating" is thought to have physiological relevance, and its severity correlates with certain measures of both positive and negative symptoms.
Johanna K. Simosky +2 more
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Comparative pharmacology of nicotine and ABT-418, a new nicotinic agonist [PDF]
Psychopharmacology, 1995 ABT-418, a novel cholinergic ligand, was reported to possess potent cognitive-enhancing and anxiolytic properties in animal models with reduced side effects (Decker et al. 1994; Garvey et al. 1994) suggesting selectivity of effects. In this study, the binding properties of ABT-418 to [3H]-nicotine sites were evaluated and its pharmacology investigated ...
K. R. Creasy +5 more
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Effects of nicotinic agonists on the NMDA receptor
Brain Research, 1991The cholinergic nicotinic agonists (-)nicotine and lobeline were observed to partially inhibit whole-cell N-methyl-D-aspartate (NMDA)-induced responses in rat cortical neurons in culture. In addition we found that (-)nicotine, (+)nicotine, and lobeline, but not the nicotine metabolite (-)cotinine nor acetylcholine, were able to displace [3H]dizocilpine
Ian J. Reynolds +2 more
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Attentional effects of nicotinic agonists in rats
Neuropharmacology, 2003Nicotine can increase stimulus detection, response rate and speed in the five-choice serial reaction time task, a rodent test of attention. In the present experiments, four other nicotinic agonists with different pharmacological profiles were compared in the same procedure.
Mohammed Shoaib +4 more
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Binding of semirigid nicotinic agonists to nicotinic and muscarinic receptors.
Molecular Pharmacology, 1989Isoarecolone methiodide (1-methyl-4-acetyl-1,2,3,6-tetrahydropyridine methiodide) was previously shown to be among the most potent agonists tested at the frog neuromuscular junction. Because nicotinic receptors from different sources vary in their selectivities, isoarecolone methiodide as well as 19 additional congeners, most of which were also ...
C E, Spivak, J A, Waters, R S, Aronstam
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Pharmacotherapy for tobacco cessation: Nicotine agonists, antagonists, and partial agonists
Current Oncology Reports, 2007Nicotine replacement therapies (NRT) were the main pharmacologic option for treatment of nicotine dependence until the early 1990s, when controlled clinical trials confirmed the efficacy of bupropion, the first treatment not based on nicotine. Varenicline, a partial agonist at nicotine receptors, gained US regulatory approval in 2006 for smoking ...
Maher Karam-Hage, Paul M. Cinciripini
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Fluorescent Agonists for the Torpedo Nicotinic Acetylcholine Receptor
ChemBioChem, 2008AbstractWe have synthesized a series of fluorescent acylcholine derivatives carrying different linkers that vary in length and structure and connect the acylcholine unit to the environment‐sensitive fluorophores 7‐(diethylamino)coumarin‐3‐carbonyl (DEAC) or N‐(7‐nitrobenz‐2‐oxa‐1,3‐diazol‐yl) (NBD).
Krieger, Florian +6 more
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