Results 201 to 210 of about 493,465 (339)

DOP090 The α7 nicotinic acetylcholine receptor agonist GTS-21 attenuate DSS-induced colitis by improving intestinal mucosal barrier function [PDF]

, 2017
Hao Zhang, Yunxia Zhu
openalex   +1 more source

Cannabidiol as a Neuroprotective Agent in Acrylamide‐Induced Neurotoxicity: Effects on Oxidative Stress, Inflammation, and Cholinergic Function in Male Mice

Journal of Neuroscience Research, Volume 103, Issue 12, December 2025.
Cannabidiol (CBD) protects against acrylamide‐induced neurotoxicity in mice by reducing oxidative stress, inflammation, and cholinergic dysfunction, while restoring BDNF levels. These findings highlight CBD's potential as a therapeutic agent for preventing environmental neurotoxicity and supporting brain health.
Korina Atsopardi, Konstantinos Mesiakaris, Ioannis Sotiropoulos, Marigoula Margarity, Konstantinos Poulas   +4 more
wiley   +1 more source

A positive allosteric modulator of α7 nAChRs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischaemia [PDF]

, 2013
Bopanna I. Kalappa, Fen Sun, Stephen R. Johnson, Kunlin Jin, Victor V. Uteshev   +4 more
openalex   +1 more source

Applying High‐Dimensional Propensity Scores in a Study of Inhaled Corticosteroids and COVID‐19 Outcomes

Pharmacoepidemiology and Drug Safety, Volume 34, Issue 12, December 2025.
ABSTRACT Background In pharmacoepidemiologic studies of COVID‐19, there were concerns about bias from residual confounding. We investigated the effects of inhaled corticosteroids (ICS) on COVID‐19 outcomes, applying high‐dimensional propensity scores (HDPS) to adjust for unmeasured confounding.
Marleen Bokern, John Tazare, Christopher T. Rentsch, Jennifer K. Quint, Ian J Douglas, Anna Schultze   +5 more
wiley   +1 more source

Discovery of Highly Potent and Selective α4β2-Nicotinic Acetylcholine Receptor (nAChR) Partial Agonists Containing an Isoxazolylpyridine Ether Scaffold that Demonstrate Antidepressant-like Activity. Part II

, 2012
Li-Fang Yu, J. Brek Eaton, Allison Fedolak, Han-Kun Zhang, Taleen Hanania, Dani Brunner, Ronald J. Lukas, Alan P. Kozikowski   +7 more
openalex   +2 more sources

Glycine Reverses Behavioral Deficits in a Mouse Model for Psychosis With 4 Copies of the Gldc Gene

Pharmacology Research &Perspectives, Volume 13, Issue 6, December 2025.
Mice with 4 copies of the glycine decarboxylase (Gldc) gene display startle habituation deficits, which are reversed by treatment with glycine. In control‐treated wild type mice (A), the response to the last startle stimuli is lower than the response to the first startle stimuli. In control‐treated mice with 4 copies of the 9p24.1 genes including Gldc (
Muxiao Wang, Maltesh Kambali, Jinrui Lyu, Rajasekar Nagarajan, Uwe Rudolph   +4 more
wiley   +1 more source

Proof-of-Concept Trial of an α7 Nicotinic Agonist in Schizophrenia

, 2006
A. Olincy, Josette G. Harris, L. Johnson, Vicki Pender, Susan Kongs, Diana Allensworth, Jamey Ellis, G. Zerbe, S. Leonard, K. Stevens, J. Stevens, Laura F. Martin, L. Adler, F. Soti, W. Kem, R. Freedman   +15 more
semanticscholar   +1 more source

Cocaine and Morphine Converge to Disrupt Chloride Homeostasis in Ventral Tegmental Area GABA Neurons

Addiction Biology, Volume 30, Issue 12, December 2025.
Drug exposure alters VTA circuitry across drug classes. We show that acute morphine and cocaine, but not saline, disrupt chloride homeostasis in VTA GABA neurons, producing a depolarized GABAA reversal potential, impaired chloride extrusion, and posttranslational downregulation of KCC2. A glucocorticoid receptor antagonist did not prevent these effects;
Anna C. Pearson, Blake A. Kimmey, Madison B. Taormina, William M. Holden, Alexey Ostroumov   +4 more
wiley   +1 more source

Modulation of Master Transcription Factor Expression of Nile Tilapia Leukocytes via Cholinergic Pathways. [PDF]

Int J Mol Sci
Girón-Pérez MI, Ramírez-Ibarra KM, Covantes-Rosales CE, Girón-Pérez DA, Razura-Carmona FF, Contis-Montes de Oca A, Morales-Montor J, Pavón L, Toledo-Ibarra GA.   +8 more
europepmc   +1 more source

The α7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain [PDF]

, 2016
Deniz Bağdaş, Jenny L. Wilkerson, Abhijit Kulkarni, Wisam Toma, Shakir D. AlSharari, Zülfiye Gül, Aron H. Lichtman, Roger L. Papke, Ganesh A. Thakur, M. Imad Damaj   +9 more
openalex   +1 more source