Results 201 to 210 of about 481,268 (346)
The Calcium Sensor Protein Visinin-like Protein-1 Modulates the Surface Expression and Agonist Sensitivity of the α4β2 Nicotinic Acetylcholine Receptor [PDF]
, 2002 Lin Lin +5 more
openalex +1 more source
Pharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.ABSTRACT Multiple muscarinic M4 receptor modulators are currently advancing in clinical development for the treatment of positive symptoms in schizophrenia, including agonists and positive allosteric modulators. Considering the importance of comprehending M4 receptor pharmacology for these therapeutic applications, this study investigates M4 receptor ...
Madeleine Merz +5 more
wiley +1 more source
Ovarian Hormones and Addictive Behaviour Vulnerability: Insights From Preclinical Studies
Addiction Biology, Volume 30, Issue 6, June 2025.ABSTRACT Substance use disorder constitutes a global health challenge. Preclinical investigations into addiction heavily rely on animal models to explore the underlying biological mechanisms of addictive disorders, with a particular emphasis on understanding the etiological factors influencing drug intake.
Leonardo Vázquez‐Morales +6 more
wiley +1 more source
A tight coupling between β\u3csub\u3e2\u3c/sub\u3eY97 and β\u3csub\u3e2\u3c/sub\u3eF200 of the GABA\u3csub\u3eA\u3c/sub\u3e receptor mediates GABA binding [PDF]
, 2011 The GABAA receptor is an oligopentameric chloride channel that is activated via conformation changes induced upon the binding of the endogenous ligand, GABA, to the extracellular inter-subunit interfaces. Although dozens of amino acid residues at the α/β
Laha, Kurt T. +2 more
core +1 more source
Alpha-7 nicotinic agonist improves cognition in schizophrenia. [PDF]
Evid Based Ment Health, 2016 Marder SR.
europepmc +1 more source
Dissecting the Functions of Conserved Prolines within Transmembrane Helices of the D2 Dopamine Receptor [PDF]
, 2011 G protein-coupled receptors (GPCRs) contain a number of conserved proline residues in their transmembrane helices, and it is generally assumed these play important functional and/or structural roles.
Dougherty, Dennis A. +2 more
core +2 more sources
Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 6, June 2025.ABSTRACT Smoking is the main cause of chronic obstructive pulmonary disease (COPD) and is associated with corticosteroid resistance. Given the paucity of data on human lung preparations, macrophages (LMs), and parenchymal explants (LPEs) were exposed to cigarette smoke extracts (CSE) in the presence or absence of lipopolysaccharide (LPS). Moreover, LMs
Marion Brollo +9 more
wiley +1 more source
Effects of a nicotinic agonist on the Brief Psychiatric Rating Scale five-factor subscale model in schizophrenia. [PDF]
Schizophr Res, 2018 Lewis AS +5 more
europepmc +1 more source