Results 211 to 220 of about 481,268 (346)

Novel FKBP prolyl isomerase 1A (FKBP12) ligand promotes functional improvement in SOD1G93A amyotrophic lateral sclerosis (ALS) mice

British Journal of Pharmacology, Volume 182, Issue 11, Page 2466-2486, June 2025.
Background and Purpose Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with limited treatment options. ALS pathogenesis involves intricate processes within motor neurons, characterized by dysregulated Ca2+ influx and buffering in early ALS‐affected motor neurones. This study proposes the modulation of ryanodine receptors (
Laura Moreno‐Martinez, Núria Gaja‐Capdevila, Laura Mosqueira‐Martín, Mireia Herrando‐Grabulosa, Laura Rodriguez‐Gomez, Klaudia Gonzalez‐Imaz, Ana C. Calvo, Maialen Sagartzazu‐Aizpurua, Leticia Moreno‐García, Jose Manuel Fuentes, Abraham Acevedo‐Arozena, Jesús María Aizpurua, José Ignacio Miranda, Adolfo López de Munain, Ainara Vallejo‐Illarramendi, Xavier Navarro, Rosario Osta, Francisco Javier Gil‐Bea   +17 more
wiley   +1 more source

Repeated Administration of the GABAB Receptor Agonist CGP44532 Decreased Nicotine Self-Administration, and Acute Administration Decreased Cue-Induced Reinstatement of Nicotine-Seeking in Rats [PDF]

, 2004
Neil E. Paterson, Wolfgang Froestl, Athina Markou   +2 more
openalex   +1 more source

Increased Nicotinic Acetylcholine Receptor Protein Underlies Chronic Nicotine-Induced Up-Regulation of Nicotinic Agonist Binding Sites in Mouse Brain

Journal of Pharmacology and Experimental Therapeutics, 2011
M. Marks, Tristan D. McClure-Begley, P. Whiteaker, O. Salminen, Robert W. B. Brown, J. Cooper, A. C. Collins, J. Lindstrom   +7 more
semanticscholar   +1 more source

Oral hyoscine butylbromide exerts spasmolytic effects in both gastrointestinal and urogenital tissues in rats

British Journal of Pharmacology, Volume 182, Issue 11, Page 2487-2502, June 2025.
Background and Purpose Hyoscine butylbromide (HBB) has a low oral (PO) bioavailability. Further, limited data on its activity on non‐gastrointestinal (GI) smooth muscle spasms after oral dosing are available, causing its effects beyond the GI tract to be questioned.
Sara Traserra, Terence Appelqvist, Robert Lange, Maura Corsetti, Marcel Jimenez   +4 more
wiley   +1 more source

Nicotinic agonist locally shot induces non-contractile slow Ca2+ (RAMIC) mobilization at the mouse neuromuscular postsynapse

, 1997
Katsuya Dezaki, Hiroshi Tsuneki, Ikuko Kimura   +2 more
openalex   +1 more source

Invariant Aspartic Acid in Muscle Nicotinic Receptor Contributes Selectively to the Kinetics of Agonist Binding [PDF]

, 2004
Won Yong Lee, Steven M. Sine
openalex   +1 more source

The Unique α4(+)/(−)α4 Agonist Binding Site in (α4)3(β2)2 Subtype Nicotinic Acetylcholine Receptors Permits Differential Agonist Desensitization Pharmacology versus the (α4)2(β2)3 Subtype

Journal of Pharmacology and Experimental Therapeutics, 2014
J. Eaton, L. Lucero, Harrison J. Stratton, Yongchang Chang, John F. Cooper, Jon M. Lindstrom, Ronald J. Lukas, P. Whiteaker   +7 more
semanticscholar   +1 more source

GLP‐1 Agonists for Pediatric Psychopharmacology: Opportunities and Cautions

Clinical and Translational Science, Volume 18, Issue 6, June 2025.
ABSTRACT Glucagon‐like peptide‐1 agonists (GLP‐1A) are increasingly prescribed to treat obesity and type 2 diabetes mellitus in children and adolescents. Emerging evidence suggesting neuropsychiatric effects presents an opportunity for pediatric psychopharmacology but requires careful consideration of potential adverse effects and risk of misuse.
Michael Bartkoski, Ethan A. Poweleit, Stephani L. Stancil   +2 more
wiley   +1 more source

Acute Effects of Four Major Trace Amines on Zebrafish Behavioral, Neurochemical, and Neuroendocrine Responses

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
A trace amine beta‐phenylethylamine is anxiolytic and reduces brain acetylcholine at 12 μg/L, but elevates anxiety and cortisol levels at 1000 μg/L. Acute tryptamine at 7 mg/L is anxiogenic, reduces shoaling and social interaction, but elevates brain acetylcholine and cortisol levels. Acute tyramine at 15 μg/L, and octopamine at 125, 500, and 1500 μg/L,
Thalia M. Quintanilha, Pietra M. Costa, Ana L. S. Cardoso, Gabrieli S. Battú, Leonardo M. Bastos, Bruno P. dos Santos, Talise E. Müller, Tiago F. de Oliveira, Angelo Piato, Allan V. Kalueff, Murilo S. de Abreu   +10 more
wiley   +1 more source

Ex vivo receptor occupation of GTS-21, a novel nicotinic receptor agonist, in rats.

, 1996
Yoshihisa Nozawa, Masato Nanri, Nobuo Kasahara, Jyunji Yamamoto, Hidekazu Miyake   +4 more
openalex   +1 more source