Results 211 to 220 of about 2,143 (224)
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HM74a Agonists: Will they be the New Generation of Nicotinic Acid?
Current Topics in Medicinal Chemistry, 2009The discovery of HM74a as a high affinity receptor for nicotinic acid has opened up new areas for investigation. Since its discovery, several new chemical entities have been reported as HM74a agonists. One of them, MK-0354, has been tested in phase II studies, but despite significant decreases in Free Fatty Acid levels with absence of flushing events ...
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Effect of nicotine and nicotinic receptor agonists on latent inhibition in the rat.
The Journal of Pharmacology and Experimental Therapeutics, 1996The present experiments assessed the influence of nicotinic cholinergic receptors on latent inhibition (LI), which is the decrement in Pavlovian conditioning resulting from extensive preexposure to a conditioned stimulus (CS). LI was assessed within a conditioned emotional response paradigm involving three phases: preexposure [either 0 (nonpreexposed ...
J, Rochford, A P, Sen, R, Quirion
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Effects of isoarecolone, a nicotinic receptor agonist in rodent models of nicotine dependence
Psychopharmacology, 2006The nicotinic receptor agonist, isoarecolone, has 'nicotine-like' subjective properties as detected by rats in a discrimination paradigm. However, isoarecolone lacks the intra-accumbens dopamine-releasing effects, a feature akin to most abused substances.
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Nicotine receptor partial agonists for alcohol dependence
Cochrane Database of Systematic Reviews, 2011Reason for withdrawal from publication This protocol is withdrawn because authors did not find time to finish the review within adequate deadlines.
Susanna Galea +5 more
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Nicotinic agonist and antagonist effects on memory
Drug Development Research, 1996Nicotine has been found by a variety of investigators to improve memory in rats, monkeys, and humans. Recent studies have helped to determine the behavioral and pharmacological nature of critical nicotine effects on memory function. Other nicotinic agonists, including ABT-418, GTS-21, or lobeline, can also significantly improve memory performance ...
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Agonists and Antagonists of Nicotinic Acetylcholine Receptors
2000The natural alkaloids nicotine and muscarine (Fig. 1) were the key pharmacologic tools that uncovered the two families of acetylcholine (ACh) receptors in the CNS. These families were defined by the action of these alkaloids to mimic the multiplicity of effects of ACh as a mediator of synaptic transmission (TAYLOR 1996).
M. W. Holladay, S. P. Arneric
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Antinociceptive profile of the new nicotinic agonist DBO-83
Drug Development Research, 1997The antinociceptive effect of DBO-83 (3-[6-Cl-pyridazin-3-yl]-diazabicyclo[3.2.1]octane) was examined in mice and rats by using the hot-plate, abdominal constriction, and paw-pressure tests. In both species, DBO-83 (10–20 mg/kg ip in the mouse; 10–20 mg/kg ip in the rat) produced significant antinociception, an effect that was prevented by mecamylamine
GHELARDINI, CARLA +3 more
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