Results 101 to 110 of about 30,934 (191)

Autonomic Nervous System in Bone Remodeling: From Mechanisms to Novel Therapies in Orthopedic Diseases

Orthopaedic Surgery, EarlyView.
Due to the close connection between the autonomic nervous system and skeletal system, large amounts of evidence have shown that neuromodulation plays a crucial role in regulating bone metabolism. Clinically, neuromodulation has exhibited promising therapeutic effects in treating joint disorders by significantly reducing inflammation and clinical scores.
Ruihao Xia, Hongjun Peng, Xishan Zhu, Wangdui Suolang, Steve T. L. Pambayi, Xiao Yang, Yi Zeng, Bin Shen   +7 more
wiley   +1 more source

Contemporary Concise Review 2024: Chronic Obstructive Pulmonary Disease

Respirology, EarlyView.
SUMMARY OF KEY POINTS Non‐smoking COPD is common in LMICs, especially in women. Biomass fuel and air pollution are major risk factors with distinct pathophysiology. The ‘eosinophilic’ endotype in COPD is biologically distinct from asthma. PRISm, FEV1/FVC Z‐scores, and quantitative CT improve early COPD detection.
Sarita Thawanaphong, Parameswaran Nair
wiley   +1 more source

Thoracic Society of Australia and New Zealand (TSANZ) Guidance for the Management of Electronic Cigarette Use (Vaping) in Adolescents and Adults

Respirology, EarlyView.
ABSTRACT Electronic cigarette (EC) use, especially among younger members of society, has grown to concerning levels in many countries, including Australia and New Zealand. Uptake in the general population, driven by technological and pharmacological innovations, and accelerated by aggressive tobacco/vaping industry marketing, has outpaced medical ...
Henry Marshall, Moya Vandeleur, Emma Dean, Chris Barton, Nia Luxton, Kristin Carson‐Chahhoud, Andre Schultz, Janet Williams, Tahlia Grammatopoulos, Emily Stone, Smita Shah, Stuart Jones, Christine F. McDonald, Matthew Peters   +13 more
wiley   +1 more source

Myths and methodologies: Invasive and non‐invasive assessment of respiratory muscle activity in humans

Experimental Physiology, EarlyView.
Abstract Survival relies on neural respiratory drive from the medullary respiratory centres to activate the respiratory muscles for breathing. Accurate assessment of respiratory muscle activity, as an estimate of neural respiratory drive in humans, will facilitate a greater understanding of respiratory physiology, the pathophysiology of diseases and ...
Anna L. Hudson, Caroline J. Jolley, Simon C. Gandevia, Jane E. Butler   +3 more
wiley   +1 more source

Test–retest reliability of Doppler ultrasound‐based leg blood flow assessments during exercise in patients with chronic obstructive pulmonary disease

Experimental Physiology, EarlyView.
Abstract Doppler ultrasound may be used to assess leg blood flow (Q̇leg${{\dot{Q}}_{{\mathrm{leg}}}}$), but the reliability of this method remains unexplored in patients with chronic obstructive pulmonary disease (COPD), where between‐subject variability may be larger than healthy due to peripheral vascular changes.
Milan Mohammad, Jacob P. Hartmann, Amalie B. Andersen, Helene L. Hartmeyer, Ulrik W. Iepsen, Ronan M. G. Berg   +5 more
wiley   +1 more source

Anthelmintic Resistance in Ancylostoma caninum: A Comprehensive Review

Veterinary Medicine and Science, Volume 11, Issue 4, July 2025.
This review summarizes the emergence of anthelmintic resistance in Ancylostoma caninum, with a focus on drug classes affected, global prevalence and resistance mechanisms. Early detection and integrated control strategies are essential to combat its spread.
Hande İrem Sönmez, Elif Madak, Mina Cansu Karaer, Hıfsı Oğuz Sarımehmetoğlu   +3 more
wiley   +1 more source

Therapeutic Targeting of the α7 Nicotinic Receptor: Challenges and Prospects for Cognitive Improvement in Alzheimer's and Schizophrenia

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 1, July 2025.
ABSTRACT The α7 nicotinic acetylcholine receptor (α7 nAChR) has emerged as a key target for treating cognitive dysfunction in neurological disorders such as Alzheimer's disease (AD) and schizophrenia. α7 nAChRs play essential roles in neurotransmission, neuroinflammation and synaptic plasticity, not only in neurons but also in glial cells, where they ...
Janus H. Magnussen
wiley   +1 more source

Methamphetamine-like discriminative-stimulus effects of nicotinic agonists. [PDF]

J Pharmacol Exp Ther, 2014
Desai RI, Bergman J.
europepmc   +1 more source

Differences in the Inflammatory Response and Corticoid Responsiveness of Human Lung Macrophages and Parenchymal Explants Exposed to Cigarette Smoke Extracts

Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 6, June 2025.
ABSTRACT Smoking is the main cause of chronic obstructive pulmonary disease (COPD) and is associated with corticosteroid resistance. Given the paucity of data on human lung preparations, macrophages (LMs), and parenchymal explants (LPEs) were exposed to cigarette smoke extracts (CSE) in the presence or absence of lipopolysaccharide (LPS). Moreover, LMs
Marion Brollo, Quentin Marquant, Hélène Salvator, Justine Cohen, Matthieu Glorion, Alexis Ferré, Martin Dres, Nicolas Roche, Stanislas Grassin‐Delyle, Philippe Devillier   +9 more
wiley   +1 more source

Alpha-7 nicotinic agonists for cognitive deficits in neuropsychiatric disorders: A translational meta-analysis of rodent and human studies. [PDF]

Prog Neuropsychopharmacol Biol Psychiatry, 2017
Lewis AS, van Schalkwyk GI, Bloch MH.
europepmc   +1 more source