Results 121 to 130 of about 34,485 (247)

A Pharmacological Comparison of Two Isomeric Nicotinic Receptor Agonists: The Marine Toxin Isoanatabine and the Tobacco Alkaloid Anatabine [PDF]

, 2020
Hong Xing, Sunil Keshwah, Anne Rouchaud, William R. Kem   +3 more
openalex   +1 more source

Spontaneous enteric nervous system activity generates contractile patterns prior to maturation of gastrointestinal motility

Neurogastroenterology &Motility, EarlyView.
Spontaneous neuronal network activity is critical for circuit maturation, yet whether this is a feature of enteric nervous system development has yet to be established. Here, we identify clustered ripples, a previously undescribed form of neurogenic gastrointestinal motility that shares many features with spontaneous neuronal networks in other systems.
Lori B. Dershowitz, Hassler Bueno Garcia, Andrew S. Perley, Todd P. Coleman, Julia A. Kaltschmidt   +4 more
wiley   +1 more source

Functional α6β4 acetylcholine receptor expression enables pharmacological testing of nicotinic agonists with analgesic properties. [PDF]

J Clin Invest, 2020
Knowland D, Gu S, Eckert WA, Dawe GB, Matta JA, Limberis J, Wickenden AD, Bhattacharya A, Bredt DS.   +8 more
europepmc   +1 more source

Test–retest reliability of Doppler ultrasound‐based leg blood flow assessments during exercise in patients with chronic obstructive pulmonary disease

Experimental Physiology, EarlyView.
Abstract Doppler ultrasound may be used to assess leg blood flow (Q̇leg${{\dot{Q}}_{{\mathrm{leg}}}}$), but the reliability of this method remains unexplored in patients with chronic obstructive pulmonary disease (COPD), where between‐subject variability may be larger than healthy due to peripheral vascular changes.
Milan Mohammad, Jacob P. Hartmann, Amalie B. Andersen, Helene L. Hartmeyer, Ulrik W. Iepsen, Ronan M. G. Berg   +5 more
wiley   +1 more source

Survival of COVID-19 patients requires precise immune regulation: The hypothetical immunoprotective role of nicotinic agonists. [PDF]

Med Hypotheses, 2020
Allahverdi Khani M, SalehiRad M, Darbeheshti S, Motaghinejad M.   +3 more
europepmc   +1 more source

In Search of the Neurobiological Substrates for Social Playfulness in Mammalian Brains

, 2011
Play behavior is a fundamental and intrinsic neurobehavioral process in the mammalian brain. Using rough-and-tumble play in the juvenile rat as a model system to study mammalian playfulness, some of the relevant neurobiological substrates for this ...
Panksepp, Jaak, Siviy, Stephen M.
core   +1 more source

Back Cover: Insight into the Binding Mode of Agonists of the Nicotinic Acetylcholine Receptor from Calculated Electron Densities (ChemPhysChem 13/2015) [PDF]

, 2015
Michael E. Beck, Oliver Gutbrod, Svend Matthiesen   +2 more
openalex   +1 more source

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

Experimental Physiology, EarlyView.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela, Anuja R. Bony, Sonia Garcia‐Caraballo, David J. Adams, Stuart M. Brierley   +4 more
wiley   +1 more source

Neurotransmitter-gated ion channels at fast chemical synapses: from structure to pathology [PDF]

, 2005
Fil: Bouzat, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur.
Bouzat, Cecilia Beatriz
core  

Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation

The Journal of Physiology, EarlyView.
Abstract figure legend A long‐term high‐fat, high‐fructose diet induces prediabetes with insulin resistance, hyperinsulinaemia, elevated triglycerides and metabolic‐associated steatotic liver disease (MASLD) in male rats. Animals developed prediabetic cardiomyopathy characterized by diastolic dysfunction, interstitial fibrosis and tachycardia ...
Anna Nilsson, Joan Escobar, Kira Kuraoka, Ian Venter, Cielo A. Carnate, Matthew W. Kay, David Mendelowitz, Kathryn J. Schunke   +7 more
wiley   +1 more source