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Nicotinic agonist and antagonist effects on memory
Drug Development Research, 1996Nicotine has been found by a variety of investigators to improve memory in rats, monkeys, and humans. Recent studies have helped to determine the behavioral and pharmacological nature of critical nicotine effects on memory function. Other nicotinic agonists, including ABT-418, GTS-21, or lobeline, can also significantly improve memory performance ...
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Agonists and Antagonists of Nicotinic Acetylcholine Receptors
2000The natural alkaloids nicotine and muscarine (Fig. 1) were the key pharmacologic tools that uncovered the two families of acetylcholine (ACh) receptors in the CNS. These families were defined by the action of these alkaloids to mimic the multiplicity of effects of ACh as a mediator of synaptic transmission (TAYLOR 1996).
M. W. Holladay, S. P. Arneric
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Antinociceptive profile of the new nicotinic agonist DBO-83
Drug Development Research, 1997The antinociceptive effect of DBO-83 (3-[6-Cl-pyridazin-3-yl]-diazabicyclo[3.2.1]octane) was examined in mice and rats by using the hot-plate, abdominal constriction, and paw-pressure tests. In both species, DBO-83 (10–20 mg/kg ip in the mouse; 10–20 mg/kg ip in the rat) produced significant antinociception, an effect that was prevented by mecamylamine
GHELARDINI, CARLA +3 more
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Agonist efficiency in a nicotinic receptor
Biophysical Journal, 2023Dinesh Indurthi, Anthony Auerbach
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