Results 141 to 150 of about 90,159 (278)

Oxymatrine Inhibits Epithelial‐Mesenchymal Transition to Alleviate Airway Remodeling in Chronic Obstructive Pulmonary Disease by Suppressing the TGF‐β1/Smad Pathway

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study explored the therapeutic efficacy of oxymatrine (OMT, C15H24N2O2) in a murine model of cigarette smoke (CS)‐induced chronic obstructive pulmonary disease (COPD) and elucidated its underlying mechanisms. A COPD model was established in mice through prolonged exposure to CS, followed by intraperitoneal administration of OMT (50 mg/kg)
Shuang Zhou, Ju‐Xiang Zhu, Jing Li
wiley   +1 more source

Nicotinic receptors as SARS-CoV-2 spike co-receptors? [PDF]

Med Hypotheses, 2022
Dormoy V, Perotin JM, Gosset P, Maskos U, Polette M, Deslée G.   +5 more
europepmc   +1 more source

PDCD5 Contributes to Airway Epithelial Cell Damage via Mitochondrial Pathway and Participates in COPD Pathogenesis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Airway epithelial injury plays a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Mitochondrial dysfunction is implicated in this injury, while the underlying mechanism remains incompletely understood. RNA sequencing was conducted to identify key genes involved in mitochondrial dysfunction in airway epithelial
Hu Shan, Rui Zhang, Yu‐er Li, Rui Li, Shao‐bo Ge, Jin Liu, Shi‐yuan Yao, Xia Yang, Tao Zhang, Ming Zhang   +9 more
wiley   +1 more source

A role for α7 nicotinic receptors in promoting stress resilience in female mice. [PDF]

Neuropsychopharmacology, 2022
Hoffman AF.
europepmc   +1 more source

Placental‐Derived Connective Tissue Matrix Mediates Murine Recurrent Laryngeal Nerve Regeneration

The Laryngoscope, EarlyView.
Placentally derived connective tissue matrix (pd‐CTM) innately contains various neurotrophic, angiogenic, anti‐inflammatory, and tissue remodeling cytokines. In this mouse model of unilateral vocal fold paralysis, we investigate its effects on recurrent laryngeal nerve (RLN) regeneration and reinnervation of the right thyroarytenoid (TA) muscle after ...
Sunjay Anekal, Ananya Tadikonda, Gabriel Sobczak, Lena W. Chen, Aditya Bhatt, Troy Wesson, Patrick R. Finnegan, Stacey Halum   +7 more
wiley   +1 more source

α3β4 Acetylcholine Nicotinic Receptors Are Components of the Secretory Machinery Clusters in Chromaffin Cells. [PDF]

Int J Mol Sci, 2022
Villanueva J, Criado M, Giménez-Molina Y, González-Vélez V, Gil A, Gutiérrez LM.   +5 more
europepmc   +1 more source

Higher Increases in Plasma n‐3 Polyunsaturated Fatty Acids Following Fish Oil Supplementation in Postmenopausal Females Compared With Age‐Matched Males

Lipids, EarlyView.
ABSTRACT The effects of fish oil supplementation on omega‐3 (n‐3) polyunsaturated fatty acids, particularly intermediates between eicosapentaenoic acid (EPA, 20:5n‐3) and docosahexaenoic acid (DHA, 22:6n‐3), that may provide valuable metabolic information, have not been fully characterized in older populations.
David C. R. Ku, Insaf Loukil, Annick Vachon, Mélanie Plourde, Adam H. Metherel   +4 more
wiley   +1 more source

Structural Insights into the Role of β3 nAChR Subunit in the Activation of Nicotinic Receptors. [PDF]

Molecules, 2022
Giastas P, Papakyriakou A, Tsafaras G, Tzartos SJ, Zouridakis M.   +4 more
europepmc   +1 more source

Long‐Term Exposure to Air Pollution and Incidence of Parkinson's Disease: A Danish Nationwide Administrative Cohort Study

Movement Disorders, EarlyView.
Abstract Background Long‐term exposure to air pollution has been linked to Parkinson's disease (PD) incidence, yet evidence is mixed, partly because of challenges with PD diagnosis and definition. We examined this association in a nationwide administrative cohort.
Thomas Cole‐Hunter, Sonja Antic, Youn‐Hee Lim, Jiawei Zhang, Laust Hvas Mortensen, Kees de Hoogh, Steffen Loft, George Maria Napolitano, Stéphane Tuffier, Marie Laura Bergmann, Bert Brunekreef, Gerard Hoek, Beate Ritz, Zorana Jovanovic Andersen, Rina So   +14 more
wiley   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source