Results 11 to 20 of about 57,977 (335)

COVID‐19 and myasthenia gravis: A review of neurological implications of the SARS‐COV‐2

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
Abstract Introduction This review highlights the potential mechanisms of neuromuscular manifestation of COVID‐19, especially myasthenia gravis (MG). Methods An extensive literature search was conducted by two independent investigators using PubMed/MEDLINE and Google Scholar from its inception to December 2020. Results Exacerbations of clinical symptoms
Syed Muhammad Ismail Shah, Farah Yasmin, Roha Saeed Memon, Nadia Nazir Jatoi, Ilma Saleh Savul, Sana Kazmi, Syed Abdullah Monawwer, Muhammad Daim Bin Zafar, Muhammad Sohaib Asghar, Muhammad Junaid Tahir, Ka Yiu Lee   +10 more
wiley   +1 more source

Bispyridinium Compounds Inhibit Both Muscle and Neuronal Nicotinic Acetylcholine Receptors in Human Cell Lines. [PDF]

PLoS ONE, 2015
Standard treatment of poisoning by organophosphorus anticholinesterases uses atropine to reduce the muscarinic effects of acetylcholine accumulation and oximes to reactivate acetylcholinesterase (the effectiveness of which depends on the specific ...
Avi Ring, Bjorn Oddvar Strom, Simon R Turner, Christopher M Timperley, Michael Bird, A Christopher Green, John E Chad, Franz Worek, John E H Tattersall   +8 more
doaj   +1 more source

Up-regulation of Nicotinic Receptors by Nicotine Varies with Receptor Subtype [PDF]

Journal of Biological Chemistry, 2008
Recent evidence suggests that in addition to alpha4beta2 and alpha3-containing nicotinic receptors, alpha6-containing receptors are present in midbrain dopaminergic neurons and involved in the nicotine reward pathway. Using heterologous expression, we found that alpha6beta2, like alpha3beta2 and alpha4beta2 receptors, formed high affinity epibatidine ...
Jean-Charles Hoda, Ryan Mastro, Daniel Bertrand, Yolanda F. Vallejo, William N. Green, Heather Walsh, Anitha P. Govind   +6 more
openaire   +3 more sources

Pharmacological receptors of nematoda as target points for action of antiparasitic drugs [PDF]

Veterinarski Glasnik, 2010
Cholinergic receptors of parasitic nematodes are one of the most important possible sites of action of antiparasitic drugs. This paper presents some of our own results of electrophysiological and pharamcological examinations of nicotinic and muscarinic ...
Trailović Saša M., Ivanović Saša R., Trailović-Nedeljković Jelena, Robertson Alan P.   +3 more
doaj   +1 more source

J‐SUPPORT research policy for oral mucositis associated with cancer treatment

Cancer Medicine, Volume 11, Issue 24, Page 4816-4829, December 2022., 2022
Abstract Background Oral mucositis is one of the main areas of research in supportive and palliative care of cancer patients. However, the methodology of prospective clinical trials on oral mucositis has not been established, despite its uniqueness.
Tomoya Yokota, Takao Ueno, Yoshihiko Soga, Hiroto Ishiki, Yasuhito Uezono, Takehiko Mori, Sadamoto Zenda, Yosuke Uchitomi   +7 more
wiley   +1 more source

Expression and function of nicotinic acetylcholine receptors in stem cells

AIMS Bioengineering, 2016
Nicotinic acetylcholine receptors are prototypical ligand gated ion channels typically found in muscular and neuronal tissues. Functional nicotinic acetylcholine receptors, however, have also recently been identified on other cell types, including stem ...
Herman S. Cheung, Jordan M. Greenberg, Carlos M. Carballosa   +2 more
doaj   +1 more source

Curiouser and Curiouser: The Macrocyclic Lactone, Abamectin, Is also a Potent Inhibitor of Pyrantel/Tribendimidine Nicotinic Acetylcholine Receptors of Gastro-Intestinal Worms. [PDF]

PLoS ONE, 2016
Nematode parasites may be controlled with drugs, but their regular application has given rise to concerns about the development of resistance. Drug combinations may be more effective than single drugs and delay the onset of resistance.
Melanie Abongwa, Samuel K Buxton, Alan P Robertson, Richard J Martin   +3 more
doaj   +1 more source

The Hair Cell α9α10 Nicotinic Acetylcholine Receptor: Odd Cousin in an Old Family

Frontiers in Cellular Neuroscience, 2021
Nicotinic acetylcholine receptors (nAChRs) are a subfamily of pentameric ligand-gated ion channels with members identified in most eumetazoan clades.
Marcela Lipovsek, Irina Marcovich, Ana Belén Elgoyhen   +2 more
doaj   +1 more source

Edaravone Administered Orally and Via Nasogastric Tube in Healthy Adults: A Comparative Bioavailability Phase 1 Study

Clinical Pharmacology in Drug Development, Volume 12, Issue 1, Page 77-84, January 2023., 2023
Abstract Intravenous edaravone is used to treat patients with amyotrophic lateral sclerosis. This randomized, open‐label, two‐way crossover, single‐dose phase 1 study compared the relative bioavailability of a newly developed edaravone oral suspension when administered orally and via a nasogastric tube (NGT) as a model of percutaneous endoscopic ...
Hidetoshi Shimizu, Yukiko Nishimura, Youichi Shiide, Masaki Ueda, Shoko Yokota, Yuichiro Kato, Manabu Hirai   +6 more
wiley   +1 more source

Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via alpha4 beta2* nicotinic receptor activation

Frontiers in Cellular Neuroscience, 2015
Acetylcholine (ACh) release onto nicotinic receptors directly activates subsets of inhibitory interneurons in hippocampal CA1. However, the specific interneurons activated and their effect on the hippocampal network is not completely understood ...
L. Andrew Bell, Karen A. Bell, Rory eMcquiston   +2 more
doaj   +1 more source