Results 271 to 280 of about 57,977 (335)

Genetic variants in nicotinic receptors and smoking cessation in Parkinson's disease. [PDF]

Parkinsonism Relat Disord, 2019
Chuang YH, Paul KC, Sinsheimer JS, Bronstein JM, Bordelon YM, Ritz B.   +5 more
europepmc   +1 more source

Purification and characterization of a protein tyrosine phosphatase which dephosphorylates the nicotinic acetylcholine receptor

, 1991
Lin Mei, Richard L. Huganir
openalex   +1 more source

Functional reconstitution of the nicotinic acetylcholine receptor by CHAPS dialysis depends on the concentrations of salt, lipid, and protein

, 1992
Theo Schuerholz, John H. Kehne, Anke Gieselmann, Eberhard Neumann   +3 more
openalex   +2 more sources

G protein‐coupled receptor‐mediated autophagy in health and disease

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan, Zeynep Aslıhan Durer, Beki Kan   +2 more
wiley   +1 more source

Novel FKBP prolyl isomerase 1A (FKBP12) ligand promotes functional improvement in SOD1G93A amyotrophic lateral sclerosis (ALS) mice

British Journal of Pharmacology, EarlyView.
Background and Purpose Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with limited treatment options. ALS pathogenesis involves intricate processes within motor neurons, characterized by dysregulated Ca2+ influx and buffering in early ALS‐affected motor neurones. This study proposes the modulation of ryanodine receptors (
Laura Moreno‐Martinez, Núria Gaja‐Capdevila, Laura Mosqueira‐Martín, Mireia Herrando‐Grabulosa, Laura Rodriguez‐Gomez, Klaudia Gonzalez‐Imaz, Ana C. Calvo, Maialen Sagartzazu‐Aizpurua, Leticia Moreno‐García, Jose Manuel Fuentes, Abraham Acevedo‐Arozena, Jesús María Aizpurua, José Ignacio Miranda, Adolfo López de Munain, Ainara Vallejo‐Illarramendi, Xavier Navarro, Rosario Osta, Francisco Javier Gil‐Bea   +17 more
wiley   +1 more source

Orientation of cobra alpha-toxin on the nicotinic acetylcholine receptor. Fluorescence studies.

, 1990
David A. Johnson, R Cushman, R Malekzadeh   +2 more
openalex   +1 more source

Oral hyoscine butylbromide exerts spasmolytic effects in both gastrointestinal and urogenital tissues in rats

British Journal of Pharmacology, EarlyView.
Background and Purpose Hyoscine butylbromide (HBB) has a low oral (PO) bioavailability. Further, limited data on its activity on non‐gastrointestinal (GI) smooth muscle spasms after oral dosing are available, causing its effects beyond the GI tract to be questioned.
Sara Traserra, Terence Appelqvist, Robert Lange, Maura Corsetti, Marcel Jimenez   +4 more
wiley   +1 more source

ESG‐1‐60 and ESG‐1‐61: Novel dopamine D3 receptor‐preferring partial agonists/antagonists that inhibit cocaine taking and seeking in rodents

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Preclinical studies suggest that highly selective dopamine D3 receptor (D3R) antagonists or partial agonists hold promise for treating substance use disorders. However, their limited effectiveness in reducing cocaine self‐administration is a major drawback.
Omar Soler‐Cedeño, Bradley M. Keegan, Hannah Alton, Guo‐Hua Bi, Emily Linz, Caleb D. Vogt, Emma S. Gogarnoiu, Lei Shi, Amy Hauck Newman, Zheng‐Xiong Xi   +9 more
wiley   +1 more source

P2Y14 receptor activation of platelets induces Ca2+ mobilization and Rho‐GTPase‐dependent motility that requires an interaction with P2Y1 receptors

British Journal of Pharmacology, EarlyView.
Background and Purpose Platelet function during inflammation is dependent on activation by endogenous nucleotides acting on purinergic receptors. The P2Y14 receptor has been reported to be expressed on platelets and is involved in leukocyte recruitment during inflammation.
Md Monir Hossain, Dingxin Pan, Kate L. Arkless, Khondaker Miraz Rahman, Clive P. Page, Kalwant S. Authi, Simon C. Pitchford   +6 more
wiley   +1 more source

Examining the Likelihood of Being Referred to the Child Welfare Services in Sweden: Influences at the Individual, Peer and School‐Area Levels

Child &Family Social Work, EarlyView.
ABSTRACT In Sweden, both maltreatment and behavioural problems are indicative of needs that motivate interventions from child welfare services (CWS). However, the likelihood of being referred to CWS can be influenced by other than indicative factors on individual, peer and school‐area levels.
Torbjörn Kalin
wiley   +1 more source