The Hair Cell α9α10 Nicotinic Acetylcholine Receptor: Odd Cousin in an Old Family
Frontiers in Cellular Neuroscience, 2021 Nicotinic acetylcholine receptors (nAChRs) are a subfamily of pentameric ligand-gated ion channels with members identified in most eumetazoan clades.
Marcela Lipovsek +2 more
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The nicotinic receptor of cochlear hair cells: A possible pharmacotherapeutic target? [PDF]
, 2009 Mechanosensory hair cells of the organ of Corti transmit information regarding sound to the central nervous system by way of peripheral afferent neurons.
Elgoyhen, Ana Belen +2 more
core +1 more source
Live-Cell Imaging of Single Receptor Composition Using Zero-Mode Waveguide Nanostructures [PDF]
, 2012 We exploit the optical and spatial features of subwavelength nanostructures to examine individual receptors on the plasma membrane of living cells. Receptors were sequestered in portions of the membrane projected into zero-mode waveguides.
Dougherty, Dennis A. +6 more
core +1 more source
Ingestion of A Common Plant’s Leaves Leads to Acute Respiratory Arrest and Paralysis: A Case Report
Clinical Practice and Cases in Emergency Medicine, 2020 Background: Nicotiana glauca is a plant known to cause acute toxicity upon ingestion or dermal exposure due to the nicotinic alkaloid, anabasine. Nicotinic alkaloids cause toxicity by acting as agonists on nicotinic-type acetylcholine receptors (nAChRs).
Breelan M. Kear +4 more
doaj +1 more source
Nicotine inhibits memory CTL programming. [PDF]
PLoS ONE, 2013 Nicotine is the main tobacco component responsible for tobacco addiction and is used extensively in smoking and smoking cessation therapies. However, little is known about its effects on the immune system.
Zhifeng Sun +5 more
doaj +1 more source
Nicotinic acetylcholine receptors and epilepsy
Pharmacological Research, 2023 Despite recent advances in understanding the causes of epilepsy, especially the genetic, comprehending the biological mechanisms that lead to the epileptic phenotype remains difficult.
Andrea Becchetti +3 more
doaj +1 more source
Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation. [PDF]
PLoS ONE, 2011 Chronic UV skin exposure leads to epidermal differentiation defects in humans that can be largely restored by pharmacological doses of nicotinic acid. Nicotinic acid has been identified as a ligand for the human G-protein-coupled receptors GPR109A and ...
Yira Bermudez +5 more
doaj +1 more source
Mechanosensitivity of nicotinic receptors [PDF]
Pflügers Archiv - European Journal of Physiology, 2012 Nicotinic acetylcholine receptors (nAChRs) are heteropentameric ligand-gated ion channels that mediate excitatory neurotransmission at the neuromuscular junction (NMJ) and other peripheral and central synapses. At the NMJ, acetylcholine receptors (AChRs) are constantly exposed to mechanical stress resulting from muscle contraction.
Pan, N. Clara +2 more
openaire +3 more sources
Trihexyphenidyl rescues the deficit in dopamine neurotransmission in a mouse model of DYT1 dystonia
Neurobiology of Disease, 2019 Trihexyphenidyl, a nonselective muscarinic receptor antagonist, is the small molecule drug of choice for the treatment of DYT1 dystonia, but it is poorly tolerated due to significant side effects.
Anthony M. Downs +4 more
doaj +1 more source
Interactions between the neuromodulatory systems and the amygdala: exploratory survey using the Allen Mouse Brain Atlas. [PDF]
, 2013 Neuromodulatory systems originate in nuclei localized in the subcortical region of the brain and control fundamental behaviors by interacting with many areas of the central nervous system.
Krichmar, Jeffrey L, Zaldivar, Andrew
core +1 more source