Results 21 to 30 of about 57,977 (335)

NICOTINIC RECEPTORS IN NEUROPSYCHIATRIC PATHOLOGIES OF ADULTHOOD AND DEVELOPMENTAL AGE. [PDF]

Euromediterranean Biomedical Journal, 2013
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels present in many regions of the central nervous system (CNS) and the peripheral nervous system.
Elettra Unti
doaj   +1 more source

Spontaneous Lipid Binding to the Nicotinic Acetylcholine Receptor in a Native Membrane [PDF]

, 2021
The nicotinic acetylcholine receptor (nAChR) and other pentameric ligand-gated ion channels (pLGICs) are native to neuronal membranes with an unusual lipid composition. While it is well-established that these receptors can be significantly modulated by lipids, the underlying mechanisms have been primarily studied in model membranes with only a few ...
arxiv   +1 more source

Ingestion of A Common Plant’s Leaves Leads to Acute Respiratory Arrest and Paralysis: A Case Report

Clinical Practice and Cases in Emergency Medicine, 2020
Background: Nicotiana glauca is a plant known to cause acute toxicity upon ingestion or dermal exposure due to the nicotinic alkaloid, anabasine. Nicotinic alkaloids cause toxicity by acting as agonists on nicotinic-type acetylcholine receptors (nAChRs).
Breelan M. Kear, Richard W. Lee, Sanford B. Church, Fady A. Youssef, Anthony Arguija   +4 more
doaj   +1 more source

Nicotine inhibits memory CTL programming. [PDF]

PLoS ONE, 2013
Nicotine is the main tobacco component responsible for tobacco addiction and is used extensively in smoking and smoking cessation therapies. However, little is known about its effects on the immune system.
Zhifeng Sun, Kendra Smyth, Karla Garcia, Elliot Mattson, Lei Li, Zhengguo Xiao   +5 more
doaj   +1 more source

A Hydrophobic Gate in an Ion Channel: The Closed State of the Nicotinic Acetylcholine Receptor [PDF]

Physical Biology, 3(2):147-159, 2006, 2005
The nicotinic acetylcholine receptor (nAChR) is the prototypic member of the `Cys-loop' superfamily of ligand-gated ion channels which mediate synaptic neurotransmission, and whose other members include receptors for glycine, gamma-aminobutyric acid, and serotonin.
arxiv   +1 more source

Resolution of complex fluorescence spectra of lipids and nicotinic acetylcholine receptor by multivariate analysis reveals protein-mediated effects on the receptor's immediate lipid microenvironment [PDF]

PMC Biophysics 2008, 1:6, 2009
Analysis of fluorescent spectra from complex biological systems containing various fluorescent probes with overlapping emission bands is a challenging task. Valuable information can be extracted from the full spectra, however, by using multivariate analysis (MA) of measurements at different wavelengths.
arxiv   +1 more source

Variants in Nicotinic Receptors and Risk for Nicotine Dependence [PDF]

American Journal of Psychiatry, 2008
A recent study provisionally identified numerous genetic variants as risk factors for the transition from smoking to the development of nicotine dependence, including an amino acid change in the alpha5 nicotinic cholinergic receptor (CHRNA5). The purpose of this study was to replicate these findings in an independent data set and more thoroughly ...
John I. Nurnberger, Oliver Reyes, Danielle M. Dick, Jay A. Tischfield, Kevin Mayo, Samuel Kuperman, Sarah Bertelsen, Victor Hesselbrock, Xiaoling Xuei, Dorothy K. Hatsukami, Richard A. Grucza, Marc A. Schuckit, John Kramer, Scott F. Saccone, Bernice Porjesz, Alison Goate, John P. Budde, William J. Horton, Nancy L. Saccone, Jerry A. Stitzel, Tatiana Foroud, John P. Rice, C. Robert Cloninger, Naomi Breslau, Gary E. Swan, Louis Fox, Eric O. Johnson, Jen C. Wang, Pamela A. F. Madden, Anthony L. Hinrichs, Ovide F. Pomerleau, Laura J. Bierut, Howard J. Edenberg   +32 more
openaire   +3 more sources

Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation. [PDF]

PLoS ONE, 2011
Chronic UV skin exposure leads to epidermal differentiation defects in humans that can be largely restored by pharmacological doses of nicotinic acid. Nicotinic acid has been identified as a ligand for the human G-protein-coupled receptors GPR109A and ...
Yira Bermudez, Claudia A Benavente, Ralph G Meyer, W Russell Coyle, Myron K Jacobson, Elaine L Jacobson   +5 more
doaj   +1 more source

Interactions between the rabies virus and nicotinic acetylcholine receptors: A potential role in rabies virus induced behavior modifications

Heliyon, 2022
Rabies causes approximately 60,000 casualties annually and has a case fatality rate approaching 100% once clinical signs occur. The glycoprotein on the surface of the virion is important for the host immune response and facilitates interaction of the ...
Marianne Lian, Karsten Hueffer, Maegan M. Weltzin   +2 more
doaj  

Alcohol and nicotinic acetylcholine receptors [PDF]

QScience Connect, 2013
Background The frequent co-abuse of alcohol and tobacco may suggest that they share some common neurological mechanisms. For example, nicotine acts on Nicotinic acetylcholine receptors (nAChRs) in the brain to release dopamine to sustain addiction. Might
Jinsong Tang, Yanhui Liao
doaj   +1 more source