Results 41 to 50 of about 57,977 (335)

Nicotinic receptor channelopathies and epilepsy [PDF]

Pflügers Archiv - European Journal of Physiology, 2009
Characterized by sudden episodes called seizures, epilepsy was recognized long ago as a neurological disorder that can have multiple forms ranging from benign to life threatening depending upon its severity. Although several evidences indicated that genes play an important role in at least half of the patients, it is only with the advances in molecular
Steinlein, Ortrud, Bertrand, Daniel
openaire   +3 more sources

Lynx Prototoxins: Roles of Endogenous Mammalian Neurotoxin-Like Proteins in Modulating Nicotinic Acetylcholine Receptor Function to Influence Complex Biological Processes

Frontiers in Pharmacology, 2019
The cholinergic system modulates many biological functions, due to the widespread distribution of cholinergic neuronal terminals, and the diffuse release of its neurotransmitter, acetylcholine.
Julie M. Miwa, Kristin R. Anderson, Katie M. Hoffman   +2 more
doaj   +1 more source

A computational insight of the improved nicotine binding with ACE2-SARS-CoV-2 complex with its clinical impact [PDF]

arXiv, 2020
Smokers being witnessed with the mild adverse clinical symptoms of SARS-CoV-2, the in-silico study is intended to explore the effect of nicotine binding to the soluble angiotensin converting enzyme II (ACE2) receptor with or without SARS-CoV-2 binding.
arxiv  

Cerebral autoregulation in patients with acute lacunar infarction: a reliable predictor of outcome

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective To further investigate the association between dynamic cerebral autoregulation (dCA) and the outcomes in patients with acute lacunar infarction. Methods Patients were prospectively and consecutively enrolled at The First Hospital of Jilin University between 2016 and 2023. dCA was monitored at 1–3 and 7–10 days after the stroke.
Xiang‐Kun Si, Song Xue, Xin Zhou, Ya‐Nan Guo, Wen‐Yu Du, Yang Qu, Xin Sun, Zhen‐Ni Guo   +7 more
wiley   +1 more source

Environmental exposure of the general population to cadmium as a risk factor of the damage to the nervous system: A critical review of current data

Journal of Applied Toxicology, Volume 43, Issue 1, Page 66-88, January 2023., 2023
Abstract Nowadays, more and more attention has been focused on the risk of the neurotoxic action of cadmium (Cd) under environmental exposure. Due to the growing incidence of nervous system diseases, including neurodegenerative changes, and suggested involvement of Cd in their aetiopathogenesis, this review aimed to discuss critically this element ...
Agnieszka Ruczaj, Małgorzata M. Brzóska   +1 more
wiley   +1 more source

Nicotinic receptors in aging and dementia [PDF]

Journal of Neurobiology, 2002
AbstractActivation of neuronal nicotinic acetylcholine receptors (nAChRs) has been shown to maintain cognitive function following aging or the development of dementia. Nicotine and nicotinic agonists have been shown to improve cognitive function in aged or impaired subjects.
MR Picciotto, ZOLI, Michele
openaire   +4 more sources

CSF Tau Is a Biomarker of Hippocampal Injury in Cryptogenic New‐Onset Refractory Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cryptogenic new‐onset refractory status epilepticus (cNORSE) is a devastating condition characterized by the de novo onset of status epilepticus with unclear etiology. The identification of relevant early biomarkers in cNORSE is important to elucidate pathophysiology, aid clinical decision‐making, and prognosticate outcomes in cNORSE.
Yihui Goh, Yoonhyuk Jang, Soo Jean Shin, Soo Hyun Ahn, Su Yee Mon, Yoon Hee Shin, Kon Chu, Sang Kun Lee, Soon‐Tae Lee   +8 more
wiley   +1 more source

Dual role of α7 nicotinic acetylcholine receptors in the retrosplenial cortex for aversive memory acquisition and retrieval

Frontiers in Behavioral Neuroscience
In the retrosplenial cortex (RSC), the role of cholinergic modulation via α7 nicotinic receptors and their involvement in memory is unknown. In recent years, the RSC has been shown to deteriorate in the early stages of Alzheimer’s disease (AD). Likewise,
Verónica Pastor, Verónica Pastor, Cynthia Katche, Cynthia Katche   +3 more
doaj   +1 more source

Nicotinic α7 acetylcholine receptor-mediated currents are not modulated by the tryptophan metabolite kynurenic acid in adult hippocampal interneurons [PDF]

, 2012
The tryptophan metabolite, kynurenic acid (KYNA), is classically known to be an antagonist of ionotropic glutamate receptors. Within the last decade several reports have been published suggesting that KYNA also blocks nicotinic acetylcholine receptors (nAChRs) containing the \alpha7 subunit (\alpha7*).
arxiv   +1 more source

Molecular adsorption study of nicotine and caffeine on the single-walled carbon nanotube from first principles [PDF]

Solid State Communications, v.167, pp.27 - 30 (2013), 2012
Using first-principles calculations, we investigate the electronic structures and binding properties of nicotine and caffeine adsorbed on single-walled carbon nanotubes to determine whether CNTs are appropriate for filtering or sensing nicotine and caffeine molecules. We find that caffeine adsorbs more strongly than nicotine.
arxiv   +1 more source