Results 101 to 110 of about 67,449 (286)

Severe Periodontitis is Associated With Recurrent Cardiovascular Events—A 10‐Year Longitudinal Cohort Study

Journal of Periodontal Research, EarlyView.
One thousand and two patients with cardiovascular disease (CVD) were observed over 10 years. Data were collected from 792 study participants. Severe periodontitis proved to be an independent risk factor for new cardiovascular events. Tooth brushing more than once a day and performing interdental hygiene were associated with decreased risk.
Stefan Reichert, Selina Rehm, Axel Schlitt, Susanne Schulz   +3 more
wiley   +1 more source

MECHANISMS OF DISEASE Acute Oxygen-Sensing Mechanisms [PDF]

, 2005
JOSEPH PRIESTLEY, ONE OF THE THREE SCIENTISTS CREDITED WITH THE discovery of oxygen, described the death of mice that were deprived of oxygen. However, he was also well aware of the toxicity of too much oxygen, stating, “For as a candle burns much faster
Buckler, Keith J., E. Kenneth Weir, M.D., López Barneo, José, Stephen L. Archer, M.D   +3 more
core  

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Effect of Calcium-Channel Blockade on the Aldosterone Response to Sodium Depletion and Potassium Loading in Man [PDF]

, 2017
Angiotensin II (Ang II) and potassium (K+) increase aldosterone (Aldo) production in vitro via Ca2+-dependent mechanisms. To determine the effects of Ca2+ antagonism in vivo, we examined the influence of nifedipine on the Aldo response to Na+ depletion ...
Favre, Laurent, Riondel, Anne, Vallotton, Michel B.   +2 more
core  

Gingival hyperplasia induced by Nifedipine: case report [PDF]

, 2002
Nifedipine, a calcium channel blocker, is commonly used in the treatment of cardiovascular disorders. In this paper a case report is presented which describes a patient medicated with Nifedipine for angina pectoris and arterial hypertension, who ...
Pićurić Ivana, Đurić Milanko
core   +1 more source

Smooth Muscle Mechanosensitivity Generates and Maintains Pressure Gradients Across the Intestine

Neurogastroenterology &Motility, EarlyView.
Mechanosensitivity of the smooth muscle induces a positive‐feedback loop that spontaneously generates pressure gradients across gut segments and stabilizes initially applied pressure gradients. It can act jointly or compete with the pressure gradient induced by directional peristaltic waves.
Richard J. Amedzrovi Agbesi, Lucas Chassatte, Nicolas R. Chevalier   +2 more
wiley   +1 more source

The effects of nifedipine on respiratory mechanics investigated by theend-inflation occlusion method in the rat

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Context: Calcium channel blockers may theoretically exhibit relaxing effects not only on vascular smooth muscle but also on airway smooth muscle. Objective: To investigate possible effects of nifedipine on respiratory mechanics in the rat.
Alessandro Rubini, Vincenzo Catena, Daniele del Monte, Gerardo Bosco   +3 more
doaj   +1 more source

Safety of Antihypertensive Medication for the Management of Non‐Severe Gestational Hypertension Among Pregnant Individuals in Botswana—Emulating a Series of Target Trials

Paediatric and Perinatal Epidemiology, EarlyView.
ABSTRACT Background Data on antihypertensive medication for non‐severe gestational hypertension may suffer from immortal time and selection bias. Emulating target trials can prevent these biases by aligning follow‐up with treatment initiation. Objectives We estimated the safety of antihypertensive medication initiation for the treatment of non‐severe ...
Julia D. DiTosto, Rebecca Zash, Denise L. Jacobson, Katherine Johnson, Modiegi Diseko, Gloria Mayondi, Judith Mabuta, Mompati Mmalane, Joseph Makhema, Sunni L. Mumford, Shahin Lockman, Roger Shapiro, Ellen C. Caniglia   +12 more
wiley   +1 more source

Promotion of cutaneous penetration of nifedipine for nanoemulsion

Brazilian Journal of Pharmaceutical Sciences, 2017
This article reports the development and characterization of a nanoemulsion (NE) able to improve the cutaneous penetration of nifedipine. NE with nifedipine was development and characterized, presenting droplet size of 20 nm with low polydispersity index
Paula de Oliveira Arantes, Quesia Nery dos Santos, Zaida Maria Faria de Freitas, Alexandre dos Santos Pyrrho, Cristal Cerqueira-Coutinho, Ana Lucia Vazquez Villa, Elisabete Pereira dos Santos, Eduardo Ricci-Júnior   +7 more
doaj   +1 more source

Suppression of premature ventricular complexes with the PDE5 inhibitor sildenafil: First clinical experience

Experimental Physiology, EarlyView.
Abstract The phosphodiesterase‐5 inhibitor sildenafil suppresses ventricular arrhythmias in a sheep model of drug‐induced long QT. In that study, ventricular arrhythmias were abolished by reducing premature ventricular complexes (PVCs) and delaying PVC onset, thus preventing ‘R‐on‐T’ ventricular tachycardia.
David C. Hutchings, Christopher P. Denton, Luigi Venetucci, Andrew W. Trafford   +3 more
wiley   +1 more source