Results 101 to 110 of about 59,868 (281)

Presynaptic quantal size enhancement counteracts post‐tetanic release depression

The Journal of Physiology, EarlyView.
Abstract figure legend Sustained high‐frequency stimulation decreases the number of synaptic vesicles that fuse per action potential at the Drosophila neuromuscular junction. However, the postsynaptic response remains largely unchanged. An increased postsynaptic response to individual vesicles, likely driven by an increase in vesicle size resulting ...
Anu G. Nair, Nasrin Bollmohr, Levin Schökle, Jennifer Keim, José María Mateos Melero, Martin Müller   +5 more
wiley   +1 more source

Cardiovascular effect of nifedipine in morphine dependent rats: hemodynamic, histopathological, and biochemical evidence [PDF]

, 2012
Aim To investigate whether administration of nifedipine has considerable therapeutic effect in morphine-dependent rats. Methods Sixty animals were randomized into control, morphine, morphine plus nifedipine, and morphine plus dimethyl sulfoxide (DMSO, as
Farzin Joukar, Mohammad Sheibani, Siyavash Joukar   +2 more
core   +2 more sources

Revisiting the merits of nifedipine [PDF]

Hypertension Research, 2011
Randomized trials of blood pressure reduction have shown a reduced risk of stroke and heart failure. Among blood pressure-lowering agents, blockers of the renin-angiotensin system, such as angiotensin-converting enzyme inhibitors (ACEIs) and AT1 receptor antagonists (ARBs), are thought to have specific properties beyond blood pressure control, which ...
openaire   +3 more sources

Determining properties of human‐induced pluripotent stem cell‐derived cardiomyocytes using spatially resolved electromechanical metrics

The Journal of Physiology, EarlyView.
Abstract figure legend In this study, we use human‐induced pluripotent stem cell‐derived cardiomyocyte (hiPSC‐CM) experiments and computational modelling to identify the mechanism of action of drug compounds. In the hiPSC‐CM experiments, optical measurements of cell collections are recorded in the baseline case and after drug exposure.
Karoline Horgmo Jæger, Verena Charwat, Kevin E. Healy, Samuel Wall, Aslak Tveito   +4 more
wiley   +1 more source

Nifedipine therapy for Prinzmetal's angina. [PDF]

, 1978
James E. Muller, Stephen Gunther
openalex   +1 more source

Kidney function in the very elderly with hypertension: data from the hypertension in the very elderly (HYVET) trial.

, 2013
BACKGROUND: numerous reports have linked impaired kidney function to a higher risk of cardiovascular events and mortality. There are relatively few data relating to kidney function in the very elderly. METHODS: the Hypertension in the Very Elderly Trial (
Beckett, Nigel, Bulpitt, Christopher, Burch, Lisa, Fagard, Robert, Fletcher, Astrid, Li, Mengying, Narkiewicz, Krzysztof, Nitsch, Dorothea, Peters, Ruth, Poulter, Ruth, Wang, Nan   +10 more
core   +1 more source

Colon cancer cell-derived 12(S)-HETE induces the retraction of cancer-associated fibroblast via MLC2, RHO/ROCK and Ca2+ signalling [PDF]

, 2016
Retraction of mesenchymal stromal cells supports the invasion of colorectal cancer cells (CRC) into the adjacent compartment. CRC-secreted 12(S)-HETE enhances the retraction of cancer-associated fibroblasts (CAFs) and therefore, 12(S)-HETE may enforce ...
Bago-Horvath, Zsuzsanna, Brendel, Konstantin Alexander, Brenner, Stefan, De Wever, Olivier, Dolznig, Helmut, Eichsteininger, Julia, Giessrigl, Benedikt, Holzner, Silvio, Huttary, Nicole, Jäger, Walter, Koperek, Oskar, Krenn, Liselotte, Krieger, Sigurd, Krupitza, Georg, Mader, Robert M, Marian, Brigitte, Milovanovic, Daniela, Nguyen, Chi Huu, Schachner, Helga, Schmidt, Wolfgang M, Senfter, Daniel, Stadler, Mira, Stadler, Serena   +22 more
core   +1 more source

Oxygen chemoreceptor inhibition by dopamine D2 receptors in isolated zebrafish gills

The Journal of Physiology, EarlyView.
Abstract figure legend Transgenic Tg(elavl3:GCaMP6s) zebrafish, which express an endogenous calcium reporter in gill oxygen chemoreceptors and nerve terminals, were used to explore the role of dopamine in hypoxia signalling. We discovered that dopamine via presynaptic dopamine D2 receptors (D2R) provides a feedback mechanism attenuating the ...
Maddison Reed, Michael G. Jonz
wiley   +1 more source

Neuromuscular synaptic function in mice lacking major subsets of gangliosides [PDF]

, 2008
Gangliosides are a family of sialylated glycosphingolipids enriched in the outer leaflet of neuronal membranes, in particular at synapses. Therefore, they have been hypothesized to play a functional role in synaptic transmission.
Ando, Ang, B. Todorov, B.C. Jacobs, Buchwald, Bullens, Chamberlain, Chen, Chiavegatto, Desplats, Egorushkina, F.M.P. Zitman, Fishman, Furuse, Gong, Green, H.J. Willison, Hakomori, Halstead, Halstead, Hashiramoto, Inoue, Isaev, J.J. Plomp, J.J. Verschuuren, K. Furukawa, K. Furukawa, Kaja, Kappel, Kawai, Lang, Ledeen, Ledeen, Liu, Magleby, Marconi, McLachlan, Meir, Nakatani, Ngamukote, O'Hanlon, Okada, Ortiz, Plomp, Proia, Rahmann, Ramirez, Roth, Salaun, Santafe, Sheikh, Simpson, Sohn, Sonnino, Stevens, Sugiura, Susuki, Svennerholm, Takamiya, Tanaka, Taverna, Tettamanti, Varoqueaux, Wang, Wieraszko, Willison, Wood, Wu, Wu, Wu, Wu, Yamashita, Yates   +72 more
core   +1 more source

Nonrecurrent Triplication of 5q21.3q23.3: A Case Report and Review of the Literature

American Journal of Medical Genetics Part A, Volume 197, Issue 5, May 2025.
ABSTRACT Triplications involving 5q21.3q23.3 are rare, and a phenotype has not been established. Here, we present a 4‐month‐old male with dysmorphic facial features and congenital cardiac malformation. Chromosomal microarray identified a pathogenic triplication of 5q21.3q23.3 with chromosome analysis showing the extra 5q material inserted into 16q ...
Jacob A. Ginter, Sarah Beaudry, Natalya Guseva, Jaime Nagy, Aaron A. Stence, Alpa Sidhu   +5 more
wiley   +1 more source