Results 101 to 110 of about 66,702 (306)

Revisiting the merits of nifedipine [PDF]

Hypertension Research, 2011
Randomized trials of blood pressure reduction have shown a reduced risk of stroke and heart failure. Among blood pressure-lowering agents, blockers of the renin-angiotensin system, such as angiotensin-converting enzyme inhibitors (ACEIs) and AT1 receptor antagonists (ARBs), are thought to have specific properties beyond blood pressure control, which ...
openaire   +3 more sources

Contribution of chloride channels to the action potential and contraction in human myometrium during labour

British Journal of Pharmacology, EarlyView.
Background and purpose The action potential underpinning calcium delivery for contraction in human uterine smooth muscle (myometrium) consists of an initial spike(s) followed by a prolonged plateau of depolarization to ⁓ −25 mV. The plateau duration establishes contraction duration, especially important in labour.
Helena C. Parkington, Ranga E. Siriwardhana, Mary A. Tonta, Shaun P. Brennecke, Penelope M. Sheehan, Marianne Tare, Harold A. Coleman   +6 more
wiley   +1 more source

A Comparative Study to Determine the Efficacy of Atosiban versus Nifedipine in Management of Preterm Labour [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Preterm Labour (PTL) remains a significant challenge in obstetrics, contributing to neonatal morbidity and mortality. The management of PTL involves the use of tocolytic agents to delay delivery, thereby allowing for further foetal ...
Vidya Gaikwad, Jay Patel, Suhas Gaikwad
doaj   +1 more source

Antihypertensive therapy for pregnancy hypertension and implications for fetal and neonatal heart rate monitoring: A systematic review of randomized trials and observational studies. [PDF]

Acta Obstet Gynecol Scand
Trials are mostly reassuring regarding antihypertensive effects on fetal (FHR) or neonatal heart rate (neoHR), but observational studies raise concerns about beta‐blockers, particularly the alpha/beta‐blocker labetalol. Clinicians should ascribe adverse fetal or neonatal heart rate effects to evolving underlying placental dysfunction or newborn illness,
Ganeshamoorthy A, Duke OF, Mistry HD, Bone JN, Vidler M, Abalos E, Badawy K, Khalil A, von Dadelszen P, Magee LA.   +9 more
europepmc   +2 more sources

Resolution of inflammation in pulmonary arterial hypertension, the influence of sex—An IUPHAR immunopharmacology committee review

British Journal of Pharmacology, EarlyView.
Pulmonary arterial hypertension (PAH) is a progressive and life‐threatening disease with limited treatment options. Sex differences are apparent in PAH, specifically in the pathophysiology, prognoses and pharmacological responses of patients. Inflammation and its resolution, which often differ between sexes, are dysregulated in chronic inflammatory ...
Chloe Landy, Miles J. De Blasio, Owen L. Woodman, Pasquale Maffia, Hong Yong Peh, Cheng Xue Qin   +5 more
wiley   +1 more source

A quad‐cistronic fluorescent biosensor system for real‐time detection of subcellular Ca2+ signals

British Journal of Pharmacology, EarlyView.
Background and Purpose The calcium ion (Ca2+) is a versatile cellular messenger regulating a variety of biological processes. Compounds modulating subcellular Ca2+ signals hold substantial pharmacological potential. Advances in fluorescent biosensors have revolutionised Ca2+ imaging.
Anna Lischnig, Yusuf C. Erdoğan, Benjamin Gottschalk, Michael Gruber, Andrea Groselj‐Strele, Sandra Burgstaller, Wolfgang F. Graier, Roland Malli   +7 more
wiley   +1 more source

Promotion of cutaneous penetration of nifedipine for nanoemulsion

Brazilian Journal of Pharmaceutical Sciences, 2017
This article reports the development and characterization of a nanoemulsion (NE) able to improve the cutaneous penetration of nifedipine. NE with nifedipine was development and characterized, presenting droplet size of 20 nm with low polydispersity index
Paula de Oliveira Arantes, Quesia Nery dos Santos, Zaida Maria Faria de Freitas, Alexandre dos Santos Pyrrho, Cristal Cerqueira-Coutinho, Ana Lucia Vazquez Villa, Elisabete Pereira dos Santos, Eduardo Ricci-Júnior   +7 more
doaj   +1 more source

Clinically applicable GABA receptor positive allosteric modulators promote ß-cell replication. [PDF]

, 2017
A key goal of diabetes research is to develop treatments to safely promote human ß-cell replication. It has recently become appreciated that activation of γ-aminobutyric acid receptors (GABA-Rs) on ß-cells can promote their survival and replication.
Dang, Hoa, Kaufman, Daniel L, Middleton, Blake, Tian, Jide   +3 more
core   +1 more source

A Retrospective Study on the Impact of Primary Aldosteronism in Pregnancy (H.A.P.P.I. Study Group)

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Primary aldosteronism (PA) is a common cause of hypertension in young women. However, there is a paucity of data regarding its impact during pregnancy. The primary objective of this study was to describe the occurrence of hypertensive disorders of pregnancy (HDP) in PA.
Diana Oprea, Frédérique Lefrançois, Matthieu St‐Jean, Anne‐Marie Côté, Marie‐Ève Roy‐Lacroix, Mandy Malick, Pierre‐Luc Mallet, Nadine Sauvé   +7 more
wiley   +1 more source

Pre-eclampsia toxaemia [PDF]

, 2013
A 33 year old primagravida rhesus positive woman was referred to the Emergency Department by her family doctor at 27 weeks gestation. At 25 weeks of gestation, she had been diagnosed with hypertension and was started on labetalol therapy.
Bugeja, Roberta, Galdes, Caroline
core