Smooth Muscle Mechanosensitivity Generates and Maintains Pressure Gradients Across the Intestine
Neurogastroenterology &Motility, EarlyView.Mechanosensitivity of the smooth muscle induces a positive‐feedback loop that spontaneously generates pressure gradients across gut segments and stabilizes initially applied pressure gradients. It can act jointly or compete with the pressure gradient induced by directional peristaltic waves.
Richard J. Amedzrovi Agbesi +2 more
wiley +1 more source
Nifedipine in the treatment of hypertension: report of a double‐blind controlled trial. [PDF]
, 1982 S. Bayley, RJ Dobbs, B.F. Robinson
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Effect of Calcium-Channel Blockade on the Aldosterone Response to Sodium Depletion and Potassium Loading in Man [PDF]
, 2017 Angiotensin II (Ang II) and potassium (K+) increase aldosterone (Aldo) production in vitro via Ca2+-dependent mechanisms. To determine the effects of Ca2+ antagonism in vivo, we examined the influence of nifedipine on the Aldo response to Na+ depletion ...
Favre, Laurent +2 more
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The effect of the calcium antagonist nifedipine on pressor and aldosterone responses to angiotensin II in normal man [PDF]
, 1983 J. A. Millar +3 more
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Calcium regulation of muscle spindle mechanosensory afferent function
Experimental Physiology, EarlyView.Abstract Extracellular calcium is crucial for the normal function of muscle spindle sensory afferents. They express multiple calcium buffering proteins. Extracellular calcium is essential for recycling of synaptic‐like vesicles (SLVs) in the terminals and for the stretch‐evoked inward calcium current of the receptor potential.
Anna Simon +5 more
wiley +1 more source
Resistant arterial hypertension in a patient with adrenal incidentaloma multiple steno-obstructive vascular lesions and antiphospholipid syndrome [PDF]
, 2015 Resistant hypertension is defined as above of blood pressure (≤ 140/90 mmHg) despite therapy with three or more antihypertensive drugs of different classes at maximum tolerable doses with one bling a diuretic.
CONCISTRE, ANTONIO +8 more
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Experimental Physiology, EarlyView.Abstract The phosphodiesterase‐5 inhibitor sildenafil suppresses ventricular arrhythmias in a sheep model of drug‐induced long QT. In that study, ventricular arrhythmias were abolished by reducing premature ventricular complexes (PVCs) and delaying PVC onset, thus preventing ‘R‐on‐T’ ventricular tachycardia.
David C. Hutchings +3 more
wiley +1 more source
Nifedipine-induced Hyperglycaemia in an Infant: A Case Report
Nigerian Journal of PaediatricsSummary: This case report describes reversible hyperglycaemia in a severely ill six-month old Saudi boy treated with nifedipine for hypertension. Hyperglycaemia became manifest on the second day of treatment with nifedipine and was not dose-related ...
Jobran Al Qhtani +6 more
doaj
RUDN Journal of Medicine, 2010 In 55 cases of nifedipine usage it's pharmacokinetics and placenta permeability index (PPI) at 25 women of the main group were studied. Pharmacokinetical parameters showed that nifedipine usage at non-severe forms of preeclampsia with placental ...
F B Buranova
doaj
Nifedipine inhibits superoxide production induced by pulsatile stretch in human aortic endothelial cells [PDF]
, 2017 Dihydropiridine calcium channel blocker nifedipine restores nitric oxide-mediated vasodilation in human hypertension. The mechanims involved have not been fully characterized but may relate to endothelial protection.
Cosentino, Francesco +2 more
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