Results 61 to 70 of about 37,594 (237)

Severe Periodontitis is Associated With Recurrent Cardiovascular Events—A 10‐Year Longitudinal Cohort Study

Journal of Periodontal Research, EarlyView.
One thousand and two patients with cardiovascular disease (CVD) were observed over 10 years. Data were collected from 792 study participants. Severe periodontitis proved to be an independent risk factor for new cardiovascular events. Tooth brushing more than once a day and performing interdental hygiene were associated with decreased risk.
Stefan Reichert, Selina Rehm, Axel Schlitt, Susanne Schulz   +3 more
wiley   +1 more source

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Smooth Muscle Mechanosensitivity Generates and Maintains Pressure Gradients Across the Intestine

Neurogastroenterology &Motility, EarlyView.
Mechanosensitivity of the smooth muscle induces a positive‐feedback loop that spontaneously generates pressure gradients across gut segments and stabilizes initially applied pressure gradients. It can act jointly or compete with the pressure gradient induced by directional peristaltic waves.
Richard J. Amedzrovi Agbesi, Lucas Chassatte, Nicolas R. Chevalier   +2 more
wiley   +1 more source

Combination Therapy of Nifedipine and Sulphonylureas Exhibits a Mutual Antagonistic Effect on the Endothelial Cell Dysfunction Induced by Hyperglycemia Linked to Vascular Disease

Cellular Physiology and Biochemistry, 2016
Background/Aims: By inducing severe endothelial impairment, hypertension and diabetes are two leading causes of morbidity and mortality. Hypertensive patients with concomitant diabetes must take both antihypertensive and hypoglycaemic medications, for ...
Li-Ping Wang, Yu Jiang, Hong Yang, Cheng Peng, Chuan Zhang, Xia Tao, He-Hui Xie   +6 more
doaj   +1 more source

The effect of Erbium:YAG Laser for the Fibronectin Expression in Gingival Epithelium with Nifedipine induced Gingival Overgrowth [PDF]

, 2021
Rasha Mostafa, Marwa Tawfiq
openalex   +1 more source

Safety of Antihypertensive Medication for the Management of Non‐Severe Gestational Hypertension Among Pregnant Individuals in Botswana—Emulating a Series of Target Trials

Paediatric and Perinatal Epidemiology, EarlyView.
ABSTRACT Background Data on antihypertensive medication for non‐severe gestational hypertension may suffer from immortal time and selection bias. Emulating target trials can prevent these biases by aligning follow‐up with treatment initiation. Objectives We estimated the safety of antihypertensive medication initiation for the treatment of non‐severe ...
Julia D. DiTosto, Rebecca Zash, Denise L. Jacobson, Katherine Johnson, Modiegi Diseko, Gloria Mayondi, Judith Mabuta, Mompati Mmalane, Joseph Makhema, Sunni L. Mumford, Shahin Lockman, Roger Shapiro, Ellen C. Caniglia   +12 more
wiley   +1 more source

Nifedipine Improves the Ketogenic Diet Effect on Insulin-Resistance-Induced Cognitive Dysfunction in Rats

Pharmaceuticals
Insulin resistance, induced by high fructose consumption, affects cognitive function negatively. Nifedipine may be suggested for neurological disorders.
Nancy M. Abdel-Kareem, Shimaa M. Elshazly, May A. Abd El Fattah, Afaf A. Aldahish, Sawsan A. Zaitone, Sahar K. Ali, Enas A. Abd El-Haleim   +6 more
doaj   +1 more source

Suppression of premature ventricular complexes with the PDE5 inhibitor sildenafil: First clinical experience

Experimental Physiology, EarlyView.
Abstract The phosphodiesterase‐5 inhibitor sildenafil suppresses ventricular arrhythmias in a sheep model of drug‐induced long QT. In that study, ventricular arrhythmias were abolished by reducing premature ventricular complexes (PVCs) and delaying PVC onset, thus preventing ‘R‐on‐T’ ventricular tachycardia.
David C. Hutchings, Christopher P. Denton, Luigi Venetucci, Andrew W. Trafford   +3 more
wiley   +1 more source

In-situ freeze-drying - forming amorphous solids directly within capsules: An investigation of dissolution enhancement for a poorly soluble drug

Scientific Reports, 2017
Conversion into the amorphous form enhances the dissolution of poorly soluble drugs, however the barrier to market for medicines containing an amorphous drug is poor stability. The aim was to produce the amorphous form of a drug within a capsule, without
Abdulmalik Alqurshi, K. L. Andrew. Chan, Paul G. Royall   +2 more
doaj   +1 more source

Differential contribution of T‐type voltage‐gated calcium channels to vascular reactivity in the aorta and renal artery of healthy rabbits

Experimental Physiology, EarlyView.
Abstract figure T‐type VGCCs contribute to the contraction of the rabbit aorta and modulate both contraction and vasodilation in the rabbit renal artery. α1, alpha 1 adrenergic receptor; ATR, angiotensin II receptor; Ang II, angiotensin II; CaM, calmodulin; Cav3, T‐type voltage‐gated Ca2⁺ channels; cGMP, cyclic guanidine monophosphate; EC, endothelial ...
Andrea Suarez, Sol Guerra‐Ojeda, Manuel Zarzoso, Marta Serna‐García, Jose M. Vila, Eva Serna, Maria D. Mauricio   +6 more
wiley   +1 more source