Results 61 to 70 of about 66,702 (306)

The Antihypertensive Drug Nifedipine Modulates the Metabolism of Chondrocytes and Human Bone Marrow-Derived Mesenchymal Stem Cells

open access: yesFrontiers in Endocrinology, 2019
Aging is associated with the development of various chronic diseases, in which both cardiovascular disorders and osteoarthritis are dominant. Currently, there is no effective treatment for osteoarthritis, whereas hypertension is often treated with L-type
Ilona Uzieliene   +11 more
doaj   +1 more source

eNOS-dependent antisenscence effect of a calcium channel blocker in human endothelial cells. [PDF]

open access: yesPLoS ONE, 2014
Senescence of vascular endothelial cells is an important contributor to the pathogenesis of age-associated vascular disorders such as atherosclerosis. We investigated the effects of antihypertensive agents on high glucose-induced cellular senescence in ...
Toshio Hayashi   +6 more
doaj   +1 more source

Recurrent Priapism After Living Donor Kidney Transplantation Requiring Bilateral T‐Shunt Procedure: A Case Report

open access: yesIJU Case Reports, EarlyView.
ABSTRACT Introduction Priapism is a persistent penile erection lasting > 4 h without sexual stimulation. Ischemic priapism requires urgent management. We report a recurrent ischemic priapism case post‐living‐donor kidney transplantation necessitating multiple interventions, including bilateral T‐shunt procedures.
Hiroto Kishino   +9 more
wiley   +1 more source

ESTIMATION OF ANTIHYPERTENSIVE EFFECT EQUABILITY FOR TWO PRESENTATIONS OF NIFEDIPINE WITH DAILY BLOOD PRESSURE MONITORING

open access: yesРациональная фармакотерапия в кардиологии, 2015
Aim. To compare information value of antihypertensive effect equability parameters for two drug formulations of nifedipine: long-acting one (nifedipine-XL) and short-acting one (nifedipine-sa).Material and methods. 147 patients with arterial hypertension
V. M. Gorbunov   +2 more
doaj   +1 more source

Bowel habits in preterm infants: Observations from the first 2 weeks of life

open access: yesJournal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Uniform descriptions of normal preterm infant bowel habits are lacking, causing ambiguity in identifying abnormal bowel habits in this population. This study examines preterm infants' bowel habits and their association with maternal and infant factors in the first 2 weeks of life. Methods An observational study included infants with
Ulrikke Lyng Beauchamp   +4 more
wiley   +1 more source

Effectiveness of 0.2% Glyceryl trinitrate and 0.5% Nifedipine in the Treatment of Chronic Anal Fissure

open access: yesJournal of Nepal Medical Association, 2017
Introduction: Anal fissure is an ischemic ulcer caused by combination of spasm of internal anal sphincter and poor blood supply to the posterior midline of anal canal.
Suman Kumar Shrestha   +3 more
doaj   +1 more source

Drug treatment of hypertension: focus on vascular health [PDF]

open access: yes, 2016
Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C.   +2 more
core   +1 more source

The Management of Parkinson's Disease Before, during and after Pregnancy—an MDS Scientific Issues Committee Review

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Pregnancy after a Parkinson's diagnosis presents complex challenges. Due to the paucity of literature, there is no evidence‐based guidelines and protocols for preconception care, management of pregnancy, childbirth and the postpartum period in women with early‐onset Parkinson's disease (PD).
Alexander C. Lehn   +18 more
wiley   +1 more source

The Effect of Topical Nifedipine in Treatment of Chronic Anal Fissure [PDF]

open access: yesActa Medica Iranica, 2010
Chronic anal fissure is the most common cause of anal pain associated with internal anal sphincter hypertonia. Reduction of hypertonocity is a special treatment for fissure healing.
Farzaneh Golfam   +3 more
doaj   +1 more source

Plateau hypoxia attenuates the metabolic activity of intestinal flora to enhance the bioavailability of nifedipine

open access: yesDrug Delivery, 2018
Nifedipine is completely absorbed by the gastrointestinal tract and its pharmacokinetics and metabolism may be influenced by microorganisms. If gut microbes are involved in the metabolism of nifedipine, plateau hypoxia may regulate the bioavailability ...
Juanhong Zhang   +5 more
doaj   +1 more source

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