Results 81 to 90 of about 66,702 (306)

School Performance After Maintenance Tocolysis With Nifedipine for Threatened Preterm Birth: 12‐Year Follow‐Up of the APOSTEL 2 Trial

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To evaluate school performance at 12 years of age in children prenatally exposed to maintenance tocolysis with nifedipine versus placebo. Design 12‐year follow‐up of the multicentre APOSTEL 2 trial, in which participants with threatened preterm birth between 26+0 and 32+2 weeks of gestation, who remained pregnant after initial 48‐h ...
Larissa I. van der Windt, Jim A. L. Meliezer, Eva Pajkrt, Marc E. A. Spaanderman, Hubertina C. J. Scheepers, Ben W. Mol, Martijn A. Oudijk, Anita C. J. Ravelli, Carolien Roos   +8 more
wiley   +1 more source

Alpha‐Ketoglutarate Ameliorates Synaptic Plasticity Deficits in APP/PS1 Mice Model of Alzheimer's Disease

Aging Cell, EarlyView.
This schematic illustration summarizes the effects of calcium alpha‐ketoglutarate (CaAKG) on synaptic plasticity in a mouse model of Alzheimer's disease (APP/PS1). CaAKG enhances autophagy and restores LTP in APP/PS1 mice via NMDAR‐independent, LTCC, and CPAMPAR‐dependent pathways.
Sheeja Navakkode, Brian K. Kennedy
wiley   +1 more source

High Altitude Pulmonary Edema Response to Continuous Airway Positive Pressure: A Randomized Controlled Trial: The HAPER CAPER Trial

Academic Emergency Medicine, EarlyView.
ABSTRACT Background Morbidity and mortality in cardiogenic pulmonary edema have been reduced by noninvasive positive‐pressure airway maneuvers. The value of continuous positive airway pressure (CPAP) for the treatment of high‐altitude pulmonary edema (HAPE) is uncertain.
Todd Bolotin, Sachin Subedi, Sushil Dahal, Christina Walker, Kimberly Chung, Ava Martz, David Gemmel, Quincy Chopra, Chad Donley   +8 more
wiley   +1 more source

Activation of Extracellular-signal Regulated Kinase (ERK1/2) by Fluid Shear is Ca\u3csup\u3e2+\u3c/sup\u3e- and ATP-dependent in MC3T3-E1 Osteoblasts [PDF]

, 2008
To determine the role of Ca2+ signaling in activation of the Mitogen-Activated Protein Kinase (MAPK) pathway, we subjected MC3T3-E1 pre-osteoblastic cells to inhibitors of Ca2+ signaling during application of fluid shear stress (FSS).
Duncan, Randall L., Geist, Derik J., Genetos, Damian C., Ke, Hua Zhe, Li, Jiliang, Liu, Dawei, Shao, Ying, Turner, Charles H.   +7 more
core   +1 more source

Slowly cycling Rho kinase-dependent actomyosin cross-bridge slippage explains intrinsic high compliance of detrusor smooth muscle [PDF]

, 2017
Biological soft tissues are viscoelastic because they display timeindependent pseudoelasticity and time-dependent viscosity. However, there is evidence that the bladder may also display plasticity, defined as an increase in strain that is unrecoverable ...
Hurley, Tanner, Klausner, Adam P., Lin, Jia B., Miner, Amy S., Neal, Christopher J., Ratz, Paul H., Speich, John E.   +6 more
core   +2 more sources

Synergistic effects of nifedipine and indomethacin in tocolysis: A translational study

International Journal of Gynecology &Obstetrics, EarlyView.
Lucile Yart, Marie Cohen, Begoña Martinez de Tejada   +2 more
wiley   +1 more source

Breast and Nipple Dermatoses During Lactation

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Lactation and breastfeeding can present both psychological and physical challenges for breastfeeding mothers. In addition, many nursing mothers will also suffer from breast and nipple dermatoses during this period, compounding these difficulties. Common causes of breast and nipple dermatitis during lactation include eczema, psoriasis, mastitis,
Hamish Moore, Annabel Stevenson
wiley   +1 more source

Combination Therapy of Nifedipine and Sulphonylureas Exhibits a Mutual Antagonistic Effect on the Endothelial Cell Dysfunction Induced by Hyperglycemia Linked to Vascular Disease

Cellular Physiology and Biochemistry, 2016
Background/Aims: By inducing severe endothelial impairment, hypertension and diabetes are two leading causes of morbidity and mortality. Hypertensive patients with concomitant diabetes must take both antihypertensive and hypoglycaemic medications, for ...
Li-Ping Wang, Yu Jiang, Hong Yang, Cheng Peng, Chuan Zhang, Xia Tao, He-Hui Xie   +6 more
doaj   +1 more source

MECHANISMS OF DISEASE Acute Oxygen-Sensing Mechanisms [PDF]

, 2005
JOSEPH PRIESTLEY, ONE OF THE THREE SCIENTISTS CREDITED WITH THE discovery of oxygen, described the death of mice that were deprived of oxygen. However, he was also well aware of the toxicity of too much oxygen, stating, “For as a candle burns much faster
Buckler, Keith J., E. Kenneth Weir, M.D., López Barneo, José, Stephen L. Archer, M.D   +3 more
core  

Cardiovascular safety of testosterone therapy—Insights from the TRAVERSE trial and beyond: A position statement of the European Expert Panel for Testosterone Research

Andrology, EarlyView.
Abstract Introduction Testosterone therapy has become a cornerstone treatment for men with hypogonadism, offering significant benefits such as improved sexual function, mood, muscle mass, and bone density. However, concerns about its cardiovascular safety have historically tempered its use.
Michael Zitzmann, Giulia Rastrelli, Robert D Murray, David Edwards, Yacov Reisman, Preethi Mohan Rao, Alexander Sahi, Thomas Hugh Jones, Alberto Ferlin, Eleni Armeni, Emiliano Corpas, Jann‐Frederik Cremers, Janine David, Stefan Arver, Leen Antonio, Giovanni Corona   +15 more
wiley   +1 more source