Results 81 to 90 of about 93,808 (329)

The Management of Parkinson's Disease Before, during and after Pregnancy—an MDS Scientific Issues Committee Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Pregnancy after a Parkinson's diagnosis presents complex challenges. Due to the paucity of literature, there is no evidence‐based guidelines and protocols for preconception care, management of pregnancy, childbirth and the postpartum period in women with early‐onset Parkinson's disease (PD).
Alexander C. Lehn, Jee‐Young Lee, Giorgia Sciacca, Stacy Patterson, Adam Morton, Paul Pun, Walaa A. Kamel, Marina Picillo, Bart Post, Eng‐King Tan, Tamine Capato, Bastiaan R. Bloem, Manon Auffret, Annelien M. Oosterbaan, Willanka Kapelle, Michiko K. Bruno, Lorraine V. Kalia, Jeffrey H. Kordower, Daniela Berg   +18 more
wiley   +1 more source

Protein binding of nifedipine

Journal of Pharmacy and Pharmacology, 1986
Abstract The protein binding of nifedipine in concentrations up to 1200 ng ml−1 has been measured in serum, pure human albumin solution and pure human α1-acid glycoprotein (AAG) solutions by ultrafiltration. The drug was extensively bound in serum from four healthy volunteers with a mean (±s.d.) fraction bound of 0.992 ± 0.008.
Lawrence J. Lesko, J Otto
openaire   +3 more sources

Built‐In Electric Field Accelerates Nanotopography‐Mediated Enhancement of Vascularized Osseointegration via Cav1.2/Piezo/Ca2+/PI3K Signaling

Small Science, EarlyView.
Nanotopography improves the piezoelectric properties of BaTiO3 due to decreased Young's modulus. Nanotopography‐mediated mechanical stress dominantly boosts osteogenesis and angiogenesis via Piezo2/Piezo1/Ca2+ signaling. Augmented electric stimulation improves mechanical stress‐mediated osteogenic/angiogenic enhancement via PI3K/AKT/mTOR/GSK3β‐1 ...
Jingyan Huang, Dongheng Lu, Cairong Xiao, Jiezhong Guan, Xiaoshuang Wang, Changhao Li, Peng Yu, Yan Wang   +7 more
wiley   +1 more source

eNOS-dependent antisenscence effect of a calcium channel blocker in human endothelial cells. [PDF]

PLoS ONE, 2014
Senescence of vascular endothelial cells is an important contributor to the pathogenesis of age-associated vascular disorders such as atherosclerosis. We investigated the effects of antihypertensive agents on high glucose-induced cellular senescence in ...
Toshio Hayashi, Tomoe Yamaguchi, Yasufumi Sakakibara, Kumiko Taguchi, Morihiko Maeda, Masafumi Kuzuya, Yuichi Hattori   +6 more
doaj   +1 more source

Fetoscopic two‐layer closure for open neural tube defects: prospective study of obstetric, surgical and perinatal outcomes in the first 50 cases

Ultrasound in Obstetrics &Gynecology, EarlyView.
ABSTRACT Objective Fetoscopic repair for open neural tube defects (ONTDs) has gained acceptance among leading groups, although it remains controversial owing to the lack of a standardized neurosurgical technique. In 2018, our group described a new fetoscopic two‐layer procedure with an exteriorized uterus for ONTD reconstruction.
C. Giné, S. Arévalo, N. Maiz, C. Rodó, E. Moreno, B. Casas, S. Manrique, M. Meléndez, M. López, E. Carreras   +9 more
wiley   +1 more source

The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation [PDF]

, 2001
<b>Objective:</b> To investigate changes in human atrial single cell functional electrophysiological properties associated with chronic atrial fibrillation (AF), and the contribution to these of accompanying ion current changes.
Kane, K.A., Rankin, A.C., Workman, A.J.
core   +1 more source

Impact of a Maternal Early Warning System and Severe Hypertension Safety Bundle on Timely Treatment of Hypertensive Emergencies: A Quality Improvement and Health Equity Initiative

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Background Hypertensive disorders of pregnancy are a leading cause of pregnancy‐related morbidity and mortality. Timely treatment of a hypertensive emergency has the potential to reduce preeclampsia‐related morbidity and mortality. Objective To evaluate the impact of quality improvement and patient safety initiatives on timely treatment of ...
Towana D. Sims, Lauren Shubert, Stacie Denning, Lena Shay, Celeste Green, Christina Davidson   +5 more
wiley   +1 more source

Activation of Extracellular-signal Regulated Kinase (ERK1/2) by Fluid Shear is Ca\u3csup\u3e2+\u3c/sup\u3e- and ATP-dependent in MC3T3-E1 Osteoblasts [PDF]

, 2008
To determine the role of Ca2+ signaling in activation of the Mitogen-Activated Protein Kinase (MAPK) pathway, we subjected MC3T3-E1 pre-osteoblastic cells to inhibitors of Ca2+ signaling during application of fluid shear stress (FSS).
Duncan, Randall L., Geist, Derik J., Genetos, Damian C., Ke, Hua Zhe, Li, Jiliang, Liu, Dawei, Shao, Ying, Turner, Charles H.   +7 more
core   +1 more source

Slowly cycling Rho kinase-dependent actomyosin cross-bridge slippage explains intrinsic high compliance of detrusor smooth muscle [PDF]

, 2017
Biological soft tissues are viscoelastic because they display timeindependent pseudoelasticity and time-dependent viscosity. However, there is evidence that the bladder may also display plasticity, defined as an increase in strain that is unrecoverable ...
Hurley, Tanner, Klausner, Adam P., Lin, Jia B., Miner, Amy S., Neal, Christopher J., Ratz, Paul H., Speich, John E.   +6 more
core   +2 more sources

Chitosan-Alginate Nanoparticles as a Novel Drug Delivery System for Nifedipine

International Journal of Biomedical Science, 2008
Chitosan-alginate (CS/ALG) nanoparticles were prepared by ionotropic pre-gelation of an alginate core followed by chitosan polyelectrolyte complexation, nifedipine was chosen as a model drug.
Ping-Lin Li, Ya-Ni Dai, Junping Zhang, Ai-qin Wang, Qin Wei   +4 more
semanticscholar   +1 more source