Results 81 to 90 of about 67,449 (286)

The Management of Parkinson's Disease Before, during and after Pregnancy—an MDS Scientific Issues Committee Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Pregnancy after a Parkinson's diagnosis presents complex challenges. Due to the paucity of literature, there is no evidence‐based guidelines and protocols for preconception care, management of pregnancy, childbirth and the postpartum period in women with early‐onset Parkinson's disease (PD).
Alexander C. Lehn, Jee‐Young Lee, Giorgia Sciacca, Stacy Patterson, Adam Morton, Paul Pun, Walaa A. Kamel, Marina Picillo, Bart Post, Eng‐King Tan, Tamine Capato, Bastiaan R. Bloem, Manon Auffret, Annelien M. Oosterbaan, Willanka Kapelle, Michiko K. Bruno, Lorraine V. Kalia, Jeffrey H. Kordower, Daniela Berg   +18 more
wiley   +1 more source

Drug treatment of hypertension: focus on vascular health [PDF]

, 2016
Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C., Lang, Ninian N., Touyz, Rhian M.   +2 more
core   +1 more source

Beyond the Michaelis–Menten: Evaluation of a tQSSA‐Based IVIVE Approach for Predicting In Vivo Intrinsic Clearance From Hepatocyte Assays

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT The classical Michaelis–Menten model, under the standard quasi‐steady‐state approximation (sQSSA), is widely used in in vitro‐in vivo extrapolation (IVIVE) studies using hepatocyte or human liver microsomal (HLM) assays to predict intrinsic hepatic clearance (Clint,vitro$$ {\mathrm{Cl}}_{\operatorname{int},\mathrm{vitro}} $$).
Ngoc‐Anh Thi Vu, Yun Min Song, Sang Kyum Kim, Hwi‐yeol Yun, Soyoung Lee, Jae Kyoung Kim, Jung‐woo Chae   +6 more
wiley   +1 more source

Lycium barbarum polysaccharides enhance testicular spermatogenesis in d‐galactose‐induced aging rats via calcium signaling

Andrology, EarlyView.
Abstract Background Lycium barbarum polysaccharide (LBP) has long been recognized as having a wide range of beneficial properties for improving proliferation. However, the protective effects and specific mechanisms of d‐galactose‐induced testicular dysfunction in reproductively senescent rats are not fully understood.
Wenxin Ma, Chang Liu, Jing Pu, Ziyu Liu, Na Hu, Li Yang, Dongmei Chen, Hongmei Li, HuiMing Ma   +8 more
wiley   +1 more source

Predictive factors for emergency cervical cerclage efficacy in singleton and twin pregnancies: A retrospective cohort study

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Emergency cerclage is associated with high offspring survival and generally comparable outcomes in both singleton and twin pregnancies. Its efficacy is influenced by several preoperative clinical factors, with gestational age at placement and the presence of prolapsed membranes emerging as the strongest predictors of delivery before 28 weeks.
Cecile C. Hulshoff, Marc E. A. Spaanderman, Ralph R. Scholten, Joris van Drongelen   +3 more
wiley   +1 more source

Cardiac dysfunction during adverse maternal outcomes in hypertensive disorders of pregnancy

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
In pregnancies complicated by hypertensive disorders, peripartum adverse maternal outcomes are associated with diastolic cardiac dysfunction. Elevated E/e' ratio and left atrial volume index highlight the need for targeted cardiovascular monitoring and long‐term follow‐up.
Veronica Giorgione, Jamie Kitt, Paul Leeson, Asma Khalil, Jamie O'Driscoll, Basky Thilaganathan   +5 more
wiley   +1 more source

Combination Therapy of Nifedipine and Sulphonylureas Exhibits a Mutual Antagonistic Effect on the Endothelial Cell Dysfunction Induced by Hyperglycemia Linked to Vascular Disease

Cellular Physiology and Biochemistry, 2016
Background/Aims: By inducing severe endothelial impairment, hypertension and diabetes are two leading causes of morbidity and mortality. Hypertensive patients with concomitant diabetes must take both antihypertensive and hypoglycaemic medications, for ...
Li-Ping Wang, Yu Jiang, Hong Yang, Cheng Peng, Chuan Zhang, Xia Tao, He-Hui Xie   +6 more
doaj   +1 more source

Human hypoxia models in aerospace medicine: Potential applications for human pharmacological research

British Journal of Clinical Pharmacology, EarlyView.
Aerospace medicine required controlled terrestrial models to investigate influences of altered atmosphere conditions, such as hypoxia, on human health and performance. These models could potentially be expanded to encompass disease conditions or treatment targets regulated through hypoxia or hypercapnia.
Titiaan E. Post, Cayla Denney, Adam Cohen, Jens Jordan, Ulrich Limper   +4 more
wiley   +1 more source

Slowly cycling Rho kinase-dependent actomyosin cross-bridge slippage explains intrinsic high compliance of detrusor smooth muscle [PDF]

, 2017
Biological soft tissues are viscoelastic because they display timeindependent pseudoelasticity and time-dependent viscosity. However, there is evidence that the bladder may also display plasticity, defined as an increase in strain that is unrecoverable ...
Hurley, Tanner, Klausner, Adam P., Lin, Jia B., Miner, Amy S., Neal, Christopher J., Ratz, Paul H., Speich, John E.   +6 more
core   +2 more sources

Nifedipine Improves the Ketogenic Diet Effect on Insulin-Resistance-Induced Cognitive Dysfunction in Rats

Pharmaceuticals
Insulin resistance, induced by high fructose consumption, affects cognitive function negatively. Nifedipine may be suggested for neurological disorders.
Nancy M. Abdel-Kareem, Shimaa M. Elshazly, May A. Abd El Fattah, Afaf A. Aldahish, Sawsan A. Zaitone, Sahar K. Ali, Enas A. Abd El-Haleim   +6 more
doaj   +1 more source