Results 191 to 200 of about 206,217 (225)

Immunometabolic Modulation by Low‐Dose Sodium Butyrate: PI3K/Akt/mTOR Signalling Orchestrates Macrophage Polarization to Protect Against Clostridioides difficile Colitis

Immunology, EarlyView.
Clostridioides difficile toxins TcdA and TcdB enter intestinal epithelial cells (IECs) via specific receptors, disrupt tight‐junction integrity and activate PI3K/Akt/mTOR signalling, promoting inflammasome assembly and IL‐1β release. Toxin‐induced IEC apoptosis further weakens the epithelial barrier.
Sisi Zhang, Zhou Jingxiang, Caixia Tan, Yuanyuan Xiao, Ju Zou, Biyue Tian, Anhua Wu, Chunhui Li   +7 more
wiley   +1 more source

Metabolotheranostics of pancreatic cancer by targeting choline, glutamine, and glucose transporters with photoimmunotherapy. [PDF]

Npj Imaging
Khandelwal P, Jin J, Barnett JD, Mironchik Y, Krishnamachary B, Yousf S, Sharma RK, Kobayashi H, Bhujwalla ZM.   +8 more
europepmc   +1 more source

Diet‐Induced Chromogenic Challenge Model for Additively Manufactured Tooth‐Colored Dental Resin Materials

Journal of Esthetic and Restorative Dentistry, EarlyView.
ABSTRACT Objectives This study aimed to evaluate the color stability of glaze‐coated 3D‐printed resin materials stored in different nutritionally beneficial smoothies that are commonly consumed. Methods Disc‐shaped (27 × 1 mm) specimens were fabricated from tooth‐colored 3D‐printed dental resins with different indications: Arma Resin (Group A ...
Ülkü Tuğba Kalyoncuoğlu, Bengi Yilmaz Erdemli, Simel Ayyildiz   +2 more
wiley   +1 more source

MT1-MMP-Targeted Photoimmunotherapy via an IR700-Conjugated Bicyclic Peptide. [PDF]

Bioconjug Chem
Kondo N, Otani T, Kanai A, Hanaoka H.
europepmc   +1 more source

Nanoparticles in Periodontology and Implant Dentistry: From Mechanisms to Clinical Applications

Journal of Periodontal Research, EarlyView.
Nanotechnology holds significant promise in improving dental care, yet there is a need for more reliable clinical studies to validate its effectiveness and safety. ABSTRACT Recent advances in nanotechnology are reshaping the landscape of periodontology and implant dentistry, particularly through the application of nanoparticles (NPs).
Chun Xu, Yuan Chen, Mario Romandini, Håvard Jostein Haugen, Sašo Ivanovski   +4 more
wiley   +1 more source

Internalization-Dependent EGFR-Targeted Photoactivation by Cetuximab-I21 Conjugates. [PDF]

J Immunother
Shang W, Shang H, Cai J, Vicky Q, Chen L, Wang H, Zhang X.   +6 more
europepmc   +1 more source

Pharmacological Modulation of Nrf2 Signaling Regulates Oxidative Stress, Inflammation, and Alveolar Bone Loss in Experimental Periodontitis

Journal of Periodontal Research, EarlyView.
Pharmacological activation of Nrf2 attenuated alveolar bone loss and protected periodontal tissues by reducing inflammation and oxidative stress, preserving collagen organization, and favoring bone homeostasis. Reversal of these effects by Nrf2 inhibition further supports Nrf2 signaling as a promising therapeutic target in periodontitis.
Vitória Bonan Costa, Mariely Araújo de Godoi, Angelo Constantino Camilli, Isabela Rinaldi Gomes Nogueira, Veronica Canela Estevam dos Santos, Lucas Nogueira Ramos, Juliana Silva Siqueira, Camila Renata Corrêa Camacho, Morgana Rodrigues Guimarães Stabili   +8 more
wiley   +1 more source

Outcomes of Near-Infrared Photoimmunotherapy for Head and Neck Cancer: A Single-Center Retrospective Study. [PDF]

Cancers (Basel)
Tahara H, Ueda T, Hattori T, Hattori M, Sato Y, Chikuie N, Taruya T, Hamamoto T, Ishino T, Takeno S.   +9 more
europepmc   +1 more source

Is Fluorescence‐Guided Surgery Reliable for the Treatment of MRONJ? A Systematic Review and Meta‐Analysis

Oral Diseases, EarlyView.
ABSTRACT Background Identification of healthy bone margins is a critical step in the surgical resective treatment of medication‐related osteonecrosis of the jaw (MRONJ). Fluorescence‐guided surgery (FGS) has been proposed as a method to identify resection margins and improve clinical outcomes.
Paolo De Angelis, Alessandro Donato Tescione, Ivan Michele Aniceto, Cosimo Rupe, Gioele Gioco, Romeo Patini, Carlo Lajolo   +6 more
wiley   +1 more source

Recovery of IR700 Fluorescence After Near-Infrared Photoimmunotherapy: Discovery and Mechanistic Insights. [PDF]

Cancers (Basel)
Tanaka H, Okuyama S, Shirota K, Sugahara M, Banba A, Ishikawa A, Minakata N, Fuchigami H, Yasunaga M, Yano T.   +9 more
europepmc   +1 more source